On March 22, 2023 BostonGene reported a collaboration with Little Warrior Foundation to drive the discovery, validation, and implementation of novel liquid biopsy solutions into sarcoma clinical practice (Press release, , MAR 22, 2023, View Source [SID1234629195]).
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Little Warrior Foundation was founded in 2020 with a simple mission to fund and find a lasting cure for childhood cancer, specifically focusing on Ewing Sarcoma. Funds the foundation raises are granted to researchers and institutions developing high-potential therapies and novel solutions for pediatric applications.
Sarcomas are malignant tumors originating in connective and supportive tissue and are incredibly diverse at the histological and molecular levels. Thus, in sarcomas, clinical decision-making often relies on the molecular features of each unique tumor. Further, sarcomas are fusion-rich, with various fusions as known drivers of myriad sarcomas, highlighting the importance of RNA-based analysis in sarcomas. Broad liquid biopsy panels have limited applicability for individual cancer types due to the unique molecular landscape of each cancer type; therefore, Little Warrior Foundation has partnered with BostonGene to develop sarcoma-specific cfDNA and cfRNA liquid biopsy assays to increase the sensitivity and accuracy of detecting sarcoma-related molecular alterations and fusions. In this collaboration, BostonGene will develop sarcoma-specific cfDNA and cfRNA liquid biopsy assays, aiming at implementing them into clinical practice for both pediatric and adult sarcomas.
"Our partnership with BostonGene enables us to accelerate research and development efforts by identifying novel solutions for patients with Ewing Sarcoma and related sarcomas," said Piero Spada, President and Co-Founder, Little Warrior Foundation. "We expect this collaboration to provide physicians with the necessary tools to monitor for relapse and reoccurrence in a more efficient manner, ultimately impacting integral clinical decisions for patients."
"We share a commitment with Little Warrior Foundation to develop and implement breakthrough solutions for patients with myriad sarcomas," said Nathan Fowler, MD, Chief Medical Officer at BostonGene. "BostonGene’s advanced sequencing and analytics will propel the development of more effective treatment strategies, ultimately positively impacting pediatric and adult patients."