On May 11, 2023 Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer, reported an encore presentation of data from the Phase 1 ALPHA/ALPHA2 trials of ALLO-501/501A at the European Hematology Association (EHA) (Free EHA Whitepaper) Hybrid Congress on June 8–11, 2023 in Frankfurt, Germany (Press release, Allogene, MAY 11, 2023, View Source [SID1234631480]).
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The ALPHA/ALPHA2 trials were designed to assess the safety, tolerability, and preliminary efficacy at increasing dose levels of ALLO-501 and ALLO-501A, allogeneic CAR T cell product candidates that target CD19. In addition to exploring cell doses, these studies evaluated escalating doses of ALLO-647, Allogene’s proprietary investigational lymphodepleting antibody designed to prevent premature rejection of AlloCAR T cells, in combination with fludarabine and cyclophosphamide.
Allogene is conducting ALPHA2 and EXPAND, two potentially pivotal Phase 2 trials of ALLO-501A in large B cell lymphoma (LBCL) in sites across the U.S. and is expected to extend its clinical research footprint to Europe, Canada and Australia in 2023.
Allogene Presentation at the 2023 EHA (Free EHA Whitepaper) Hybrid Congress:
Title: Durable Responses Achieved with Anti-CD19 Allogeneic CAR T ALLO-501/501A in Phase 1 Trials of Autologous CAR T Naïve Patients with Relapsed/Refractory Large B Cell Lymphoma (R/R LBCL)
Presenter: Dr. Javier Munoz, M.D., M.B.A, Director of the Lymphoma Program at Mayo Clinic in Phoenix, Arizona
Abstract: P1125
Poster Session Display Date and Time: Friday, June 9, 2023, 18:00 – 19:00 CEST/ 9:00AM – 10:00AM PT/ 12:00PM – 1:00PM ET
About ALLO-501 and ALLO-501A
ALLO-501 and ALLO-501A are anti-CD19 AlloCAR T investigational products for the treatment of large B cell lymphoma. ALLO-501A, a next-generation anti-CD19 AlloCAR T, eliminates the rituximab recognition domains in ALLO-501, which could allow for use in a broader patient population, including NHL patients with recent rituximab exposure. This product candidate is currently being studied in an ongoing Phase 2 trial. In June 2022, the U.S. Food and Drug Administration granted Regenerative Medicine Advanced Therapy (RMAT) designation to ALLO-501A in r/r LBCL.