On September 12, 2023 Dewpoint Therapeutics and Chemify reported a partnership to develop a suite of digitally discovered and automatically synthesized novel molecules on Chemify’s programmable chemistry platform against condensate targets of interest in Dewpoint’s oncology and neurodegeneration pipeline (Press release, Dewpoint Therapeutics, SEP 12, 2023, View Source [SID1234635119]).
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The partnership brings together Chemify’s pioneering chemistry AI and automation technology platform, capable of designing, discovering and making complex molecules on demand using a chemical programming language, with Dewpoint’s groundbreaking condensate biology and AI technology platform. Chemify, who recently announced raising $43M of funding (read more), has developed an automated design, discovery and synthesis platform, which will be employed to amplify and accelerate Dewpoint’s ongoing chemistry efforts.
Under the partnership, Chemify will design and deliver novel compounds to augment Dewpoint’s advanced oncology and neurodegeneration pipeline. Dewpoint may choose to exercise an option to acquire the compounds designed by Chemify. In exchange, Chemify will receive pre-negotiated, success-driven clinical and regulatory milestones and tiered royalties.
"Dewpoint’s partnership with Chemify offers an innovative pathway to take our novel chemical matter already in optimization and bootstrap Chemify’s novel chemical space exploration tool suite using state-of-the-art digital chemistry AI-powered concepts. This is a new frontier for drug discovery and we’re delighted to partner with Chemify who is at the cutting-edge of this approach," commented Ameet Nathwani, M.D., CEO at Dewpoint.
"We are extremely excited by this partnership which combines Chemify’s technology for molecular design, discovery and synthesis with Dewpoint’s condensate biology approach to produce a seamless drug discovery and design platform. It is truly inspiring to be using the Chemify technology I have been building for 15 years to change and improve the lives of patients," commented Professor Lee Cronin, Chemify’s CEO and Regius Professor of Chemistry at the University of Glasgow.
About Condensates
Condensates are membraneless organelles that form dynamically throughout the cell via a process called phase separation. These subcellular compartments organize and concentrate molecules within cells to enable certain key biochemical processes. The dysregulation of biomolecular condensates has been observed in many diseases, including cancer, diabetes and neurological disorders. Dewpoint’s platform has discovered disease-driving condensates and developed condensate-modifying drugs that potentially provide novel therapeutic options for complex diseases and historically undruggable targets.