On October 5, 2023 Aadi Bioscience, Inc. (NASDAQ: AADI), a biopharmaceutical company focused on developing and commercializing precision therapies for patients with mTOR pathway alterations, reported that two posters will be presented at the upcoming North American Neuroendocrine Tumor Society (NANETS) Multidisciplinary NET Medical Symposium, taking place October 4-6, 2023, in Montreal, Canada (Press release, Aadi Bioscience, OCT 5, 2023, View Source [SID1234635698]).
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Details of the poster presentations are below:
Title: "Phase 2 study of nab-sirolimus in patients with well-differentiated and advanced or metastatic neuroendocrine tumors of the gastrointestinal tract, lung, or pancreas"
Date/Time: Thursday, October 5, 2023, 5:15 pm – 7:00 pm EDT
Presentation Location: Poster Gallery Location, Square Dorchester
Presenter: Scott Paulson, MD
Authors: Michael J. Demeure, MD; Allen L. Cohn, MD; Tara Seery, MD; Li Ding, MS, MA; Usman Aziz, MD; Willis Navarro, MD; Scott Paulson, MD
Highlights:
The PI3K/AKT/mTOR pathway has been implicated in the pathogenesis and progression of NETs, though the use of oral mTORis as a treatment for NETs is limited by low bioavailability and the heterogeneity of the disease
nab-Sirolimus is a nanoparticle albumin-bound mTORi designed to preferentially target tumors and overcome the limitations of oral sirolimus
nab-Sirolimus is currently approved in the United States for the treatment of malignant perivascular epithelioid cell neoplasms
The efficacy and safety of nab-sirolimus in patients with advanced or metastatic NETs will be evaluated in this phase 2, multicenter, open-label, single-arm, US-based study
The study, NET-202 (NCT05997056), will enroll up to 21 efficacy evaluable patients at approximately three US centers. Enrollment for the study is planned to begin in the third quarter of 2023, with completion expected within 12–18 months
An encore presentation titled, "Phase 2, Multicenter, Open-label Basket Trial of nab-Sirolimus for Malignant Solid Tumors Harboring Pathogenic Inactivating Alterations in TSC1 and TSC2 (PRECISION1)" will also be presented on Thursday, October 5, 2023.
More information can be found on the North American Neuroendocrine Tumor Society (NANETS) website.