On October 18, 2023 CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of conditionally activated, localized biologics, reported that the Company presented data characterizing the preclinical profile of its EpCAM-targeting ADC, CX-2051, at the World ADC conference taking place October 16-19, 2023, in San Diego, CA (Press release, CytomX Therapeutics, OCT 18, 2023, View Source [SID1234636104]).
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"CX-2051 is designed to address the unmet needs of patients with EpCAM-expressing tumors, including colorectal cancer, where EpCAM expression is uniformly high. EpCAM is a broadly expressed, validated anti-cancer target that to date has been limited in its development potential due to systemic, on-target off-tumor dose-limiting toxicities", said Marcia P. Belvin, Ph.D., senior vice president and chief scientific officer at CytomX.
Continued Dr. Belvin, "Based on our experience with the Probody Platform and our clinical experience with Probody-ADCs, we have designed CX-2051 to mask target binding in normal tissues and include a next-generation topoisomerase-1 inhibitor payload. We are encouraged by the compelling preclinical profile of CX-2051 and anticipate filing an IND for the program by the end of the year. We aim to launch Phase 1 dose escalation for CX-2051 in solid tumors in 2024, with an initial focus in metastatic colorectal cancer as a priority indication."
Details for the presentation are as follows:
Presentation Title: Leveraging Conditional Activation to Localize Antibody Drug Conjugates to the Tumor
"Clinical Lessons" Track
Session Date and Time: October 18, 2023, 12:30 pm PST
The full presentation is available at the following link:
Leveraging Conditional Activation to Localize Antibody Drug Conjugates to the Tumor
Marcia P. Belvin, Ph.D., Senior Vice President, Chief Scientific Officer, CytomX Therapeutics