On October 25, 2023 Larkspur Biosciences, a biotechnology company building precision therapies to outsmart cancer, reported that data supporting development of a novel investigational therapy targeting Pin1 will be featured in a poster presentation at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) (SITC 2023) on November 3 in San Diego, CA (Press release, Larkspur Biosciences, OCT 25, 2023, View Source [SID1234636329]). The data look at how the potential therapy will target Pin1 to program fibroblasts to drive a pro-immune response at the tumor.
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"Larkspur Biosciences was founded to pursue targets shared by cancer and immune cells that the cancer hijacks to evade immunity. Our data at SITC (Free SITC Whitepaper) 2023 demonstrates that Pin1 is a promising cancer–fibroblast target to pursue for therapeutic interventions," said Catherine Sabatos-Peyton, PhD, CEO of Larkspur Biosciences. "Standard of care immunotherapy has revolutionized cancer treatment, but less than 30 percent of patients respond. At Larkspur, we believe there is an opportunity to leverage targets shared by both the cancer and the immune system as a more effective way to activate the immune system against cancer."
Presentation Details:
Poster: Abstract 1433
Title: "Targeting peptidyl-prolyl isomerase Pin1 to modulate cancer-associated fibroblast phenotype and TGF-beta signaling "
Time: Friday, November 3, 12-1:30pm and 5:10-6:40pm PT
Location: San Diego Convention Center, Exhibit Halls A and B1
Presenter: Melvyn Chow, PhD, Associate Director, Biology, Larkspur Biosciences