On March 16, 2023 Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) (Actinium or the Company), a leader in the development of targeted radiotherapies, reported that two abstracts have been accepted for presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2023 Annual Meeting being held April 14 – 19, 2023 in Orlando, Florida (Press release, Actinium Pharmaceuticals, MAR 16, 2023, View Source [SID1234628948]). The abstracts highlight the multifaceted anti-cancer activity of CD33-targeted clinical-stage asset Actimab-A and enhanced anti-tumor effect of HER3-targeted, radiotherapy being developed in collaboration with AVEO Oncology, an LG Chem Company.
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Accepted presentations will feature data that continue to support potent anti-tumor activity of Actinium’s first-in-class HER3 radiotherapy in preclinical models of cancers with unmet therapeutic needs, as well as new data evaluating novel applications of Actimab-A to selectively deplete CD33+ myeloid-derived suppressor cells (MDSCs), a highly immunosuppressive cell type that is a major component of the tumor microenvironment.
"Actinium is applying our significant experience in developing and advancing clinical-stage targeted radiotherapeutics to further bolster our R&D leadership position in the field. We are excited to highlight new data from our HER3 targeting radiotherapy program as well as our novel strategy utilizing Actimab-A to deplete MDSCs, reactivating T cell responses in the tumor microenvironment at this year’s AACR (Free AACR Whitepaper) annual meeting.", said Sandesh Seth, Actinium’s Chairman & Chief Executive Officer. Mr. Seth continued, "These exciting new data demonstrate Actinium’s focus on being at the leading edge of targeted radiotherapy innovation and working to develop differentiated therapies to address unmet medical needs. With our recently signed CRADA with the NCI, we have secured broad support for Actimab-A that could include trials focused on MDSC depletion in a number of disease indications given the broad, mutation agnostic applicability of Actimab-A, while our creative approach to collaborating has allowed us to advance our HER3 initiative rapidly."
The abstracts are available on AACR (Free AACR Whitepaper)’s website. Actinium’s presentation details are as follows:
Abstract Title: Targeting myeloid-derived suppressor cells with actinium-225 lintuzumab, a CD33 antibody radioconjugate to enhance antitumor immunity
Session Category: Clinical Research Excluding Trials
Session Title: Immunomodulatory Agents and Interventions
Session Date and Time: Tuesday Apr 18, 2023: 9:00 AM – 12:30 PM
Location: Poster Section 40
Poster Board Number: 7
Published Abstract Number: 4421
Abstract Title: Novel HER3 targeting antibody radioconjugates, 225Ac-HER3 ARC and 177Lu-HER3 ARC, exhibit potent antitumor efficacy in HER3-positive solid tumors
Session Category: Experimental and Molecular Therapeutics
Session Title: Theranostics and Radionuclides / Pharmacologic Approaches
Session Date and Time: Tuesday Apr 18, 2023: 1:30 PM – 5:00 PM
Location: Section 19
Poster Board Number: 7
Abstract Presentation Number: 5040