On January 19, 2016 Advaxis, Inc. (NASDAQ:ADXS), a clinical stage biotechnology company developing cancer immunotherapies, reported that it has added two more patents to its growing patent portfolio (Press release, Advaxis, JAN 19, 2016, View Source [SID:1234508805]). The first patent, European Patent No. 1804831, expands the composition of matter claims covering HER-2 tumor antigens. The second patent, U.S. Patent No. 9,226,958, expands the use of the Company’s Lm Technology beyond oncology, specifically to induce an immune response in parasitically infected patients. Schedule your 30 min Free 1stOncology Demo! "These patents broaden our protection in HER2 and expand our reach beyond oncology, into parasitically infected patients," said Daniel J. O’Connor, President and Chief Executive Officer of Advaxis. "We are continuing to work diligently on our patent portfolio, currently with 90 granted patents and 111 pending applications, worldwide."
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Advaxis is the exclusive licensee of both of these patents. European Patent No. 1804831 will expire on September 14, 2025 and U.S. Patent 9,226,958 will expire on October 3, 2031. The company has an extensive patent portfolio that protects its product candidates and Listeria monocytogenes (Lm) based immunotherapy technology. The Company currently owns or has rights to more than 200 patents and applications globally, which are owned, licensed from, or co-owned with the Trustees of the University of Pennsylvania, Merck, Sharpe & Dohme BV, the National Institutes of Health, the University of Georgia Research Foundation, Inc., and Georgia Regents University. Its patents currently extend protection through 2032.
About HER2 Expressing Solid Tumor Cancers
Human epidermal growth factor receptor 2 (HER2) is overexpressed in a percentage of solid tumors such as breast, gastric, bladder, brain, pancreatic, ovarian and pediatric bone cancer (osteosarcoma). The American Cancer Society estimates that in 2015 in the United States alone there will be 231,840 new cases of invasive breast cancer; 24,590 new cases of gastric cancer; 74,000 new cases of bladder cancer; 22,850 new cases of brain/spinal cancer; 48,960 new cases of pancreatic cancer; 21,290 new cases of ovarian cancer; and 207 new cases of pediatric osteosarcoma. HER2 expression is associated with more aggressive disease, increased risk of relapse and decreased overall survival, and is an important target for immunotherapy.
About ADXS-HER2
ADXS-HER2 is an Lm Technology immunotherapy product candidate being developed by Advaxis to target HER2 expressing cancers. ADXS-HER2 has received orphan drug designation by the U.S. Food and Drug Administration (FDA) for the treatment of osteosarcoma. Advaxis is developing ADXS-HER2 for both human and animal health, and has seen encouraging data in canine osteosarcoma, which is considered a model for human osteosarcoma. Advaxis has licensed ADXS-HER2 and three other immunotherapy constructs to Aratana Therapeutics, Inc. for the development of pet therapeutics.