On November 17, 2020 Agendia, Inc., a world leader in precision oncology for breast cancer, reported that it will present new data from ongoing clinical research evaluating the MammaPrint and BluePrint genomic tests at the upcoming 2020 San Antonio Breast Cancer Symposium (SABCS 2020), taking place virtually December 8-11, 2020 (Press release, Agendia, NOV 17, 2020, View Source [SID1234571284]).

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These data, which build upon existing clinical research that demonstrates the efficacy of MammaPrint and BluePrint testing to consistently inform optimal treatment planning, highlight Agendia’s many trials in progress that will ultimately impact patient treatment and outcomes.

Specific data selected for poster spotlight discussions include:

BluePrint performance in predicting pertuzumab benefit in genomically HER2-positive patients: a biomarker analysis of the APHINITY trial
Authors: Krop, I., et al.
Session: Spotlight Poster Discussion 3 | Wednesday, December 9, 2020 | 6:30pm – 7:30pm CST
Poster #: PD3-01
5-year outcomes in the NBRST trial: Preoperative MammaPrint and BluePrint breast cancer subtype is associated with neoadjuvant treatment response and survival
Authors: Whitworth, P., et al.
Session: Spotlight Poster Discussion 9 | Thursday, December 10, 2020 | 3:30pm – 4:45pm CST
Poster #: PD9-01
In addition, Laura van’t Veer, PhD, co-founder and Chief Research Officer at Agendia, will be giving an oral presentation on an abstract entitled "How low is low risk: MINDACT updated outcome and treatment benefit in patients considered clinical low risk and stratified by genomic signature, age and nodal status."

"The MammaPrint and BluePrint assays give patients with breast cancer and their healthcare providers the precise information they need to determine which treatment approach is the most targeted and effective for their situation," says William Audeh, MD, MS, Chief Medical Officer at Agendia. "Our continued efforts to identify and understand the biologic drivers of breast cancer in large patient populations have also enabled us to look within these to study unique subsets of people, and to offer additional important insights, as we continue to expand knowledge in breast cancer and build a library of data that will be of benefit to patients."

Following are details of additional Agendia abstracts that have been accepted for SABCS 2020:

How low is low risk: MINDACT updated outcome and treatment benefit in patients considered clinical low risk and stratified by genomic signature, age and nodal status
Authors: van’t Veer, L.J., et al.
Session: General Session 4 | Friday, December 11, 2020 | 8:45am – 11:30am CST
Poster #: PS6-01
Presentation #: Oral Presentation GS4-11 | Presentation 11:15am-11:25am CST | Live Q&A Session 11:25am-11:30am CST
Molecular subtyping by BluePrint improves prediction of treatment responses and survival outcomes in patients with discordant clinical and genomic classification
Authors: Whitworth, P., et al.
Session: Poster Session 4
Poster #: PS4-04
The 70-gene signature (MammaPrint) accurately predicts distant breast cancer recurrence risk in patients aged ≥70 years from the population-based observational FOCUS cohort.
Authors: Noordhoek, I., et al.
Session: Poster Session 6
Poster #: PS6-06
Comparing MammaPrint and BluePrint results between core needle biopsy and surgical resection breast cancer specimens
Authors: McKelley, J., et al.
Session: Poster Session 6
Poster #: PS6-19
MammaPrint and BluePrint as prognostic indicators for elderly patients with early stage breast cancer
Authors: Blumencranz, P.W., et al.
Session: Poster Session 6
Poster #: PS6-41
Racial disparities within Basal-type breast cancer: clinical and molecular features of African American and Caucasian obese patients
Authors: Sharma, D., et al.
Session: Poster Session 7
Poster #: PS7-68
Molecular profiles and clinical-pathological features of Asian early-stage breast cancer patients
Authors: Chen, M., et al.
Session: Poster Session 7
Poster #: PS7-69
Differential gene expression analysis and clinical utility of MammaPrint and BluePrint in male breast cancer patients
Authors: Crozier, J., et al.
Session: Poster Session 14
Poster #: PS14-11
Differential gene expression in Luminal-type invasive lobular carcinoma and invasive ductal carcinoma by MammaPrint risk stratification
Authors: Lesnikoski, B., et al.
Session: Poster Session 18
Poster #: PS18-03
Using BluePrint to elucidate the molecular heterogeneity of triple negative breast cancers
Authors: Kaklamani, V.G., et al.
Session: Poster Session 18
Poster #: PS18-05
The FLEX real-world data platform explores new gene expression profiles and investigator-initiated protocols in early stage breast cancer
Authors: Lee, L., et al.
Session: Ongoing Trials Posters
Poster #: OT-12-01
These data underscore Agendia’s mission to help guide the diagnosis and personalized treatment of breast cancer for all patients throughout their treatment journey.

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