On September 13, 2021 Alkermes plc (Nasdaq: ALKS) reported two poster presentations related to nemvaleukin alfa (nemvaleukin), the company’s novel, investigational, engineered interleukin-2 (IL-2) variant immunotherapy, at the 2021 European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Congress, taking place Sept. 16-21, 2021 (Press release, Alkermes, SEP 13, 2021, View Source [SID1234587585]). The presentations will include a trial-in-progress poster for ARTISTRY-6, a global phase 2 trial evaluating the anti-tumor activity, safety and tolerability of nemvaleukin monotherapy in patients with melanoma who have been previously treated with anti-PD-(L)1 therapy, with or without anti-CTLA-4 therapy, and a poster showing data from a preclinical study that evaluated the anti-tumor efficacy of a mouse ortholog of nemvaleukin as monotherapy and in combination with chemotherapy in a murine model of small cell lung cancer.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
"We’re pleased to share updates from the nemvaleukin development program with the scientific and medical community at ESMO (Free ESMO Whitepaper). This year’s posters include information on our ongoing ARTISTRY-6 clinical trial in melanoma, which is designed to support potential registration in mucosal melanoma, and data from a preclinical study that investigated the potential of nemvaleukin in combination with chemotherapy," said Craig Hopkinson, M.D., Chief Medical Officer and Executive Vice President of Research & Development at Alkermes. "We look forward to continuing to explore nemvaleukin’s potential as a novel, differentiated therapy for patients with high unmet need across a wide array of tumor types."
Details of the presentations are as follows:
Abstract: 834
Title: ARTISTRY-6: Nemvaleukin alfa monotherapy in patients with advanced mucosal and cutaneous melanoma
Presenter: Richard D. Carvajal, M.D., Director of Experimental Therapeutics and Director of the Melanoma Service at Columbia University Medical Center
Presentation Date: The poster presentation will be available on demand to attendees beginning Sept. 16, 2021.
Abstract: 3326
Title: Anti-tumor efficacy and immune profiling of the mouse ortholog of nemvaleukin alfa, a novel engineered IL-2 fusion protein, in an orthotopic mouse model of small cell lung cancer alone or in combination with standard chemotherapy
Presenter: Yuanwang Pan, Ph.D., Postdoctoral Fellow, Immuno-Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health
Presentation Date: The poster presentation will be available on demand to attendees beginning Sept. 16, 2021.
About Nemvaleukin Alfa ("nemvaleukin")
Nemvaleukin is an investigational, novel, engineered fusion protein comprised of modified interleukin-2 (IL-2) and the high affinity IL-2 alpha receptor chain, designed to preferentially expand tumor-killing immune cells while avoiding the activation of immunosuppressive cells by selectively binding to the intermediate-affinity IL-2 receptor complex. The selectivity of nemvaleukin is designed to leverage the proven anti-tumor effects of existing IL-2 therapy while mitigating certain limitations.
About the ARTISTRY Clinical Development Program
ARTISTRY is an Alkermes-sponsored clinical development program evaluating nemvaleukin as a potential immunotherapy for cancer. The ARTISTRY program is comprised of multiple clinical trials evaluating intravenous and subcutaneous dosing of nemvaleukin, both as a monotherapy and in combination with the anti-PD-1 therapy KEYTRUDA (pembrolizumab) in patients with advanced solid tumors. Ongoing trials in the ARTISTRY program include: ARTISTRY-1, ARTISTRY-2, ARTISTRY-3 and ARTISTRY-6.