On November 12, 2021 Alligator Bioscience AB ("Alligator") and Aptevo Therapeutics ("Aptevo") reported that preclinical data on ALG.APV-527, a potentially first-in-class bispecific targeting both 4-1BB and tumor antigen 5T4 will be presented in a poster at the Society for Immunotherapy Cancer’s (SITC) (Free SITC Whitepaper) 36th Annual Meeting, taking place virtually and in-person on November 12th – 14th, 2021 in Washington D.C (Press release, Alligator Bioscience, NOV 12, 2021, View Source [SID1234595320]). The poster highlights preclinical datasets as an overview of the potential indication landscape, mechanism of action and the efficacy profile of ALG.APV-527, which support the molecule’s progression into the clinic.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Poster # 796 entitled, "ALG.APV-527: A tumor directed bispecific approach utilizing ADAPTIR technology designed for conditional 4-1BB T cell/NK agonism against solid tumors," will be available on-demand starting today or displayed on-site on Saturday, November 13th. The poster describes the dual expression of CD8 and 5T4 in several tumor indications that will support the clinical development. To complement the in vivo anti-tumor data previously shown, the poster shows in vitro, that combining ALG.APV-527 and a bispecific T-cell engager promotes enhanced immune cell-mediated tumor cell killing better than the T-cell engager alone.
"ALG.APV-527 is designed to elicit safe and efficacious 4-1BB-mediated antitumor activity in a range of 5T4-expressing tumor indications. The differentiated design of the molecule minimizes systemic immune activation and risk of hepatotoxicity, allowing for highly efficacious tumor-specific responses as demonstrated by potent activity in in vitro models," stated Michelle H. Nelson, PhD., Principal Scientist at Aptevo. "Based on these preclinical data, ALG.APV-527 is a promising anti-cancer therapeutic for the treatment of a variety of 5T4-expressing solid tumors and the programme is progressing towards a phase I clinical trial."
Title: ALG.APV-527: A 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors
Presenter: Michelle H. Nelson, PhD (Aptevo Therapeutics)
Date/Time: Saturday, November 13th