On October 18, 2021 AnHeart Therapeutics ("AnHeart"), a clinical-stage global biopharmaceutical company committed to developing novel precision oncology therapies, reported sponsored research to evaluate AB-329, an AXL inhibitor in metastatic breast cancer (Press release, AnHeart Therapeutics, OCT 18, 2021, View Source [SID1234591466]). The coprimary investigators of the study are Jangsoon Lee, Ph.D., and Naoto Ueno, M.D., both of The University of Texas MD Anderson Cancer Center.
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In breast cancer, AXL expression independently predicts poor overall patient survival. Activation of AXL kinase activity or overexpression of AXL is associated with drug resistance in multiple cancers.
"We are excited to launch this study to evaluate AXL inhibitor AB-329 in metastatic breast cancer, an area of significant unmet medical need," said Bing Yan, M.D., MBA, Co-Founder & Chief Medical Officer, AnHeart. "Metastatic breast cancer (mBC) has limited therapeutic regimens. Although long-term survival rates for patients with mBC have improved, toxicity and resistance to conventional treatment remain major clinical problems for mBC."
"We look forward to this study as it will enable us to identify molecules and chemotherapy agents to enhance the anti-tumor and anti-metastatic efficacy of our investigational candidate AB-329 in AXL-positive metastatic triple-negative breast cancer," said Jerry Junyuan Wang, Ph.D., CEO and Co-Founder of AnHeart. "The results will allow us to propose new treatment options with AB-329 for future clinical trials. There is an urgent unmet medical need to advance new therapeutic strategies for patients with metastatic triple-negative breast cancer and inflammatory breast cancer."