On November 3, 2022 Artiva Biotherapeutics, Inc., a clinical stage company whose mission is to deliver highly effective, off-the-shelf, allogeneic natural killer (NK) cell-based therapies that are safe and accessible to cancer patients, reported the presentation of preclinical efficacy data combining anti-CD38 antibodies with AB-101, the Company’s clinical-stage ADCC-enhancer product candidate, in multiple myeloma models (Press release, Artiva Biotherapeutics, NOV 3, 2022, View Source [SID1234622911]). The data will be presented at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) (ASH 2022) Annual Meeting & Exposition taking place December 10-13, in New Orleans.

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"These data provide additional support for the versatility of AB-101 as a highly scaled, off-the-shelf, ADCC-enhancing NK cell product candidate for therapeutic use in combination with monoclonal antibodies and NK cell engagers," said Peter Flynn, Ph.D., cofounder and Chief Operating Officer of Artiva. "Specifically, these data support the use of our platform in combination with anti-CD38 antibodies such as DARZALEX and SARCLISA, without the requirement for engineering or editing of our NK cells."

The data to be presented highlight the naturally low expression of CD38 and high and consistent expression of CD16 on AB-101, enabling its use with anti-CD38 antibodies for enhanced ADCC activity without the requirement for CD38 editing. AB-101 resistance to daratumumab-induced fratricide and glucocorticoid inhibition will be presented as well as preclinical in vitro activity and in vivo efficacy of the AB-101 combination with anti-CD38 antibodies.

Details of the presentation are as follows:

Title: Pre-Clinical Efficacy of AB-101, an Allogeneic Cord-Blood Derived Natural Killer (NK) Cell Therapeutic Candidate, in Combination with Anti-CD38 Antibodies in Models of Multiple Myeloma

About AB-101

AB-101 is a cord blood-derived, allogeneic, cryopreserved, ADCC-enhancing NK cell therapy candidate for use in combination with monoclonal antibodies or innate-cell engagers. Artiva selects cord blood units with the high affinity variant of the receptor CD16 and a KIR-B haplotype for enhanced product activity. Artiva can generate thousands of doses of pure, cryopreserved, infusion-ready NK cells from a single umbilical cord blood unit while retaining the high and consistent expression of CD16 without the need for engineering. Artiva is conducting a Phase 1/2 multicenter clinical trial (ClinicalTrials.gov Identifier: NCT04673617) to assess the safety and clinical activity of AB-101 alone and in combination with the anti-CD20 monoclonal antibody, rituximab, in patients with relapsed or refractory B-cell-non-Hodgkin lymphoma (NHL) who have progressed beyond two or more prior lines of therapy.