On June 14, 2022 aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase biology platform, reported that new findings from its platform will be presented in a poster today at the Keystone Symposia Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapeutics in Keystone, CO (Press release, aTyr Pharma, JUN 14, 2022, View Source [SID1234615971]).
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The poster presents findings from aTyr’s innovative tRNA synthetase platform, whereby selected fragments of Alanyl-tRNA Synthetase (AARS) and Aspartyl-tRNA Synthetase (DARS) were found to bind to the surface of specific human cell types via novel binding partners. Additionally, the target receptor of the fragment AARS-1 was identified as fibroblast growth factor receptor 4 (FGFR4), indicating that AARS-1 may have therapeutic potential in fibrosis, inflammation and cancer. Moreover, the methods utilized in the study can be further employed to identify and validate new molecular targets from aTyr’s tRNA synthetase platform.
Details of the poster presentation appear below. The poster will be available on the aTyr website once presented.
Title: Identification of key extracellular binding proteins implicate role in inflammation and fibrosis for alanyl- and aspartyl-tRNA synthetases
Authors: Ryan A. Adams, Tarsis F. Brust, Yeeting E. Chong, Ann L. Menefee, Andrew Imfeld, Michaela Ferrer, Zachary Fogassy, Alison G. Barber, Suzanne Paz, Leslie A. Nangle. aTyr Pharma, San Diego.
Poster Number: 2022
Poster Session: Poster Session 2
Date: Tuesday, June 14, 2022
"We are very pleased that our novel approach to drug discovery has yielded the identification of a receptor target for yet another tRNA synthetase from our platform," said Sanjay S. Shukla, M.D., M.S., President and CEO of aTyr. "The target receptor identified for the fragment AARS-1, FGFR4, is involved in many cellular processes including cell proliferation, differentiation and tissue repair. FGFR4 is known to play a role in diseases related to inflammation and fibrosis, including conditions where unchecked fibrosis can precede the development of certain cancers. We look forward to further interrogating the interaction between AARS-1 and FGFR4 and the implications for disease in order to explore this synthetase fragment as a potential pipeline candidate.