On December 10, 2021 aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways, reported a presentation at the Antibody Engineering & Therapeutics Conference which is being held December 12 – 16, 2021 in San Diego, CA, and virtually (Press release, aTyr Pharma, DEC 10, 2021, View Source [SID1234596772]).
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The presentation will discuss the practical utility of repertoire data for antibody affinity maturation, including clonal grouping of sequencing data with lead candidates to understand likely maturation pathways and partially mature antibodies with minimal effort, complementing existing methods. aTyr’s tRNA synthetase biology platform is focused on elucidating novel pathways mediated through extracellular response and creating new biologics to modulate these pathways, by either developing protein therapies based on extracellular tRNA synthetase fragments or generating monoclonal antibodies to target the pathway. Engineering techniques that enhance the affinity and selectivity of antibodies can accelerate the development of antibody therapeutics against novel targets.
Details of the presentation are as follows:
Title: Practical Utility of Repertoire Data for Antibody Affinity Maturation
Presenter: Luke Burman, Senior Scientist. aTyr Pharma, San Diego, CA.
Session: Workshop B: When High Affinity is Necessary in Antibody Therapeutics
Date: Sunday, December 12, 2021
Time: 2:15pm PST / 5:15pm EST
"We are excited to present on this novel approach that highlights aTyr’s cutting-edge, in-house antibody engineering techniques," said Leslie Nangle, Ph.D., Vice President, Research at aTyr. "These methods have broad applicability for aTyr’s tRNA synthetase platform and present an opportunity to support the expansion of our pipeline with enabling technology that accelerates the development of antibody candidates with high affinity and selectivity for their receptor targets."