Aura Biosciences to Present Preclinical Data Highlighting AU‑011’s Potential to Target a Broad Number of Tumor Types at the 2022 AACR Annual Meeting

On March 8, 2022 Aura Biosciences Inc. (NASDAQ: AURA), a clinical-stage biotechnology company developing a novel class of virus-like drug conjugate (VDC) therapies for multiple oncology indications, reported the presentation of preclinical data for its first VDC product candidate, AU-011 which is being developed for the treatment of life-threatening cancers with high unmet need, including primary choroidal melanoma and non-muscle invasive bladder cancer (Press release, Aura Biosciences, MAR 8, 2022, View Source [SID1234609710]). The results demonstrate the potential wide applicability of AU-011 in targeting a number of solid tumor types and will be presented as part of the 2022 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, being held April 8-13, 2022 in New Orleans, LA.

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"The data that will be presented at AACR (Free AACR Whitepaper) provide evidence for AU-011’s activity in tumors that express specifically modified heparan-sulfate proteoglycans on the tumor cell surface. Activity was observed in every tumor type tested, indicating that there are numerous solid tumors we can consider to expand the clinical development of AU-011, including those derived from neural or epithelial lineages," said Dr. Cadmus Rich, Chief Medical Officer and Head of R&D of Aura Biosciences. "The correlative gene expression analysis has deepened our understanding of the genes and biological pathways involved in the expression of HSPGs by different types of tumor cells."

Details for the poster presentation are as follows:

Title: Biological Assessment of the Virus-Like Drug Conjugate AU-011 to Specifically Target a Breadth of Human Cancer Types
Presenter: Rhonda Kines, Aura Biosciences
Poster Session: ETO1 Drug Discovery
Date and time: April 8, 2022, 1:00 PM ET
Location: E-poster
Session Category: Experimental and Molecular Therapeutics
Session Title: Drug Discovery
Abstract Number: 5331