On January 7, 2021 Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) reported that management will present at the J.P. Morgan Healthcare Conference on Monday, January 11, 2021 at 9:10 a.m. ET (6:10 a.m. PT) (Press release, Vertex Pharmaceuticals, JAN 7, 2021, View Source [SID1234573672]).

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The audio portion of management’s remarks can be accessed live through Vertex’s website, www.vrtx.com, in the "Investors" section under the "News and Events" page. A replay of the conference webcast will be archived on the company’s website.

On January 7, 2021 Saniona (OMX: SANION), a clinical stage biopharmaceutical company focused on rare diseases, reported that Rami Levin, President and Chief Executive Officer of Saniona, will present in the following three upcoming virtual investor conferences (Press release, Saniona, JAN 7, 2021, View Source [SID1234573671]):

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10th Annual LifeSci Partners Corporate Access Event
Date: Thursday, January 7, 2021
Time: 11:30 a.m. Eastern Time
Presentation and 1×1 Meetings
Webcast Link: View Source

Biotech Showcase
Date: Monday, January 11 – Friday, January 15, 2021
Time: On demand
Presentation and 1×1 Meetings
Webcast Link: https://informaconnect.com/biotech-showcase/digital-experience/

BIO CEO and Investor Digital Conference
Date: Tuesday, February 16 – Thursday, February 18, 2021
Time: On demand
Presentation and 1×1 Meetings
Webcast Link: View Source

As available, these events will be made accessible and archived for approximately 90 days on the Saniona website in the Company Presentations section: View Source

On January 7, 2021 Affimed N.V. (Nasdaq: AFMD), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, reported an update on its pipeline and business (Press release, Affimed, JAN 7, 2021, View Source,on%20its%20pipeline%20and%20business. [SID1234573670]). "Affimed ended 2020 with significant momentum across all major programs and a strong balance sheet that provides cash runway into the first half of 2023," commented CEO Adi Hoess. "With three innate cell engagers in clinical development and multiple active collaborations, Affimed is positioned for numerous catalysts in 2021 and beyond."

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Clinical Stage Program Updates
AFM13 (CD30/CD16A ICE)

AFM13-202, a Phase 2 registration-directed study of AFM13 as monotherapy in relapsed or refractory patients with CD30-positive peripheral T-cell lymphoma (pTCL), remains ahead of schedule and Affimed expects to complete the interim data analysis during the first half of 2021.
The first dose cohort of AFM13-104, an investigator sponsored Phase 1 study at The University of Texas MD Anderson Cancer Center evaluating the tolerability and efficacy of AFM13 preloaded cord blood-derived NK cells (cbNK) followed by weekly AFM13 monotherapy in patients with refractory CD30 expressing lymphomas, is ongoing.
AFM24 (EGFR/CD16A ICE)

AFM24-101, a Phase 1/2a clinical trial of AFM24, the EGFR/CD16A targeted ICE for treatment of patients with EGFR-expressing solid tumors, has completed dose cohort 3 (80 mg per patient) without showing dose limiting side effects and patients are currently being enrolled and treated in dose cohort 4 (160 mg per patient).
Affimed and NKMax America completed a pre-IND meeting with the U.S. Food and Drug Administration in December 2020. The companies plan to submit an IND in the first half of 2021 for a Phase1/2a study to investigate different dose levels of AFM24 in combination with NKMax America’s autologous NK cell product SNK01 in patients with EGFR expressing solid tumors.
Other Business Updates
As of December 31, 2020, Affimed’s preliminary unaudited cash and cash equivalents were approximately €147 million. Based on its current operating plan and assumptions, Affimed anticipates that its cash and cash equivalents will support operations into the first half of 2023.

On January 7, 2021 TLC (Nasdaq: TLC, TWO: 4152), a clinical-stage specialty pharmaceutical company developing novel nanomedicines to target areas of unmet medical need, reported that it has been invited to attend the 39th annual JP Morgan Healthcare Conference, scheduled to take place January 10-14, 2021 (Press release, Taiwan Liposome Company, JAN 7, 2021, View Source [SID1234573669]).

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JP Morgan Healthcare Conference has been and is the largest and most information healthcare investment symposium in the industry, with attendance of over 8,000 participants each year. This year, the conference will be conducted entirely virtually over the internet instead of physically taking place at the Westin St. Francis Hotel in San Francisco as per tradition, in an effort to impede the spread of COVID-19.

TLC will be attending the conference for the seventh year in a row at the invitation-only event. Members of TLC’s management team will provide updates on the status of the Company’s innovative product candidates, including TLC599 and TLC590, which are non-opioids with the potential to provide extended relief of osteoarthritis pain and postsurgical pain, respectively.

On January 7, 2021 Alteogen Inc. (KOSDAQ:196170) reported that it has entered into an exclusive license agreement with Intas Pharmaceuticals Ltd. to use ALT-B4, Alteogen’s novel hyaluronidase – derived utilizing the Hybrozyme technology – to develop and commercialize two products (Press release, Alteogen, JAN 7, 2021, View Source [SID1234573668]).

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Under the terms of the agreement, Alteogen has granted worldwide rights, except for a few Asian countries, for Intas to develop two products in combination with ALT-B4. Alteogen will receive an initial payment of USD 6 Million and is also eligible to receive additional milestones upon Intas’ achievement of specified development, regulatory and sales milestones, totaling up to USD 109 Million. In addition, Alteogen will be entitled to receive a tiered royalty ranging from mid-single digit to low double digit on sales of commercialized products. Alteogen will be responsible for regulatory development and commercial supply of ALT-B4 to Intas.

"We are pleased to enter into this agreement with Intas, a fast growing and leading pharmaceutical company," said Dr. Soon Jae Park, Chief Executive Officer of Alteogen, "we look forward to collaborating with Intas in bringing two products to the market for the benefit of patients".

"We are truly excited by this partnership, which brings together the expertise and heritage of Alteogen with Intas’ strong development and manufacturing capabilities as well as extensive commercial reach," said Mr. Binish Chudgar, Vice Chairman of Intas Pharmaceuticals, "this agreement underlines our vision and commitment to increasing access to life-changing medicines that can make a real difference to patient lives."

About ALT-B4

ALT-B4 is Alteogen’s proprietary human recombinant human hyaluronidase enzyme developed utilizing the Hybrozyme technology. ALT-B4 can enable the large volume subcutaneous administration of drugs that are typically administered as an IV injection. ALT-B4 does this by temporarily hydrolyzing hyaluronan in the extracellular matrix.