On November 30, 2020 ImmunoGen Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that the Company will host a conference call at 8:00am ET on Monday, December 7, 2020 to discuss updated findings from the first-in-human trial of IMGN632, an antibody-drug conjugate targeting CD123, in patients with relapsed/refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN) to be presented in an oral session at the 62nd American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting on December 5, 2020 (Press release, ImmunoGen, NOV 30, 2020, View Source [SID1234571996]). During the call, Dr. Naveen Pemmaraju, Associate Professor in the Department of Leukemia at MD Anderson Cancer Center, will summarize the data presented during the oral session and management will provide an update on the pathway to FDA approval for IMGN632 in BPDCN as well as recent progress in the acute myeloid leukemia (AML) program.

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CONFERENCE CALL INFORMATION

To access the live call by phone, dial (877) 621-5803; the conference ID is 1795760. The call, along with associated slides, may also be accessed through the Investors and Media section of immunogen.com. Following the call, a replay will be available at the same location.

On November 30, 2020 Shanghai Stock Exchange listed company HitGen Inc. ("HitGen") reported that it has entered into a research collaboration agreement with Cedilla Therapeutics, Inc. ("Cedilla"), a private biotechnology company developing targeted small molecules for the treatment of cancer and other diseases caused by protein dysregulation (Press release, HitGen, NOV 30, 2020, View Source [SID1234571994]). The companies will conduct joint research to identify and develop drug candidates directed to a validated, high-value target in oncology that has remained beyond the reach of previous efforts.

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HitGen is a world leading biotech company in DNA encoded library-screening, a high throughput compound screening technology, where more than 100,000 times larger libraries can be used than in traditional drug discovery. The platform thus enables faster identification of innovative drug candidates with improved target specificity and enhanced drug-like characteristics.

Pursuant to the terms of the collaboration agreement, HitGen has successfully applied its DEL technology and discovered program compounds that met certain criteria, and Cedilla has received an exclusive license to these compounds as well as associated IP for further development and commercialization. HitGen will be eligible for milestone payments and sublicensing income from Cedilla as the project progresses, in addition to research payments and upfront license fee.

"HitGen is a perfect partner for us in this program, with their cutting-edge DEL platform for screening. Their technology is well established and is now widely used by leading global pharmaceutical and biotech companies," said Dr. Alexandra Glucksmann, President and CEO of Cedilla. "With HitGen’s support, we are able to accelerate our ongoing efforts to pursue a breadth of high-value oncology targets that have eluded conventional therapeutic modalities. We are very pleased with the program compounds discovered by HitGen to date, are excited to advance these programs forward as we pursue our mission of delivering profound benefit to patients in areas of high unmet need."

"We are delighted to enter this collaboration with Cedilla, and believe their unique approach to identifying functionally-relevant proteoforms represents a powerful advance in how we think about treating diseases caused by protein dysregulation," said Dr. Jin Li, Chairman of the Board and Chief Executive Officer of HitGen. "We believe the collaboration will reinforce the role and reputation of HitGen’s platform in the rapidly developing field of DEL and further demonstrates the power of our DEL platform to discover novel small molecules against a variety of targets. We are working closely with Cedilla scientists and have seen early success towards generating new small-molecule lead compounds for their research programs to help bring transformative medicines to patients."

On November 30, 2020 Tyme Technologies, Inc. (NASDAQ: TYME), an emerging biotechnology company developing cancer metabolism-based therapies (CMBTsTM), announced that, effective November 24, 2020, Steve Hoffman will remain in the role of Chairman of the board of directors and continue as the Company’s Chief Science Officer, after a successful tenure as Chief Executive Officer since 2015 (Press release, TYME, NOV 30, 2020, View Source [SID1234571993]). Richie Cunningham, former Icagen CEO and Boehringer Ingelheim executive, has been appointed as TYME’s next Chief Executive Officer.

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"We are fortunate to have been able to identify and bring on an individual with Mr. Cunningham’s significant experience in key facets sought by emerging biotech companies. His leadership and expertise in the biopharmaceutical industry, as well as his knowledge of efficient partnering strategies will be invaluable in helping TYME establish itself as a commercial organization with a pipeline of next-generation metabolic-based compounds," said Steve Hoffman, Chairman and Chief Science Officer of TYME.

Mr. Cunningham brings more than 20 years of successful leadership experience spanning from pre-IND drug discovery through the commercialization and launch of over a dozen therapies in oncology, rare disease, infectious disease, respiratory, neurology, cardiovascular and metabolic diseases. Richie brings to TYME an in-depth understanding of maximizing therapeutic lifecycles, enhancing efficiencies and outcomes in biotech business models, and most importantly a commitment to a values-driven culture.

Mr. Cunningham also brings significant experience in mergers & acquisitions, business development, strategy development, therapeutic launches, contracting, managed care, and sales & marketing. Most recently, Richie served as CEO at Icagen, leading the company through two transformational acquisitions, acquiring assets and talent out of Pfizer and Sanofi. While CEO at Icagen, he successfully negotiated and signed multiple licensing deals with Roche, Sanofi and the Cystic Fibrosis Foundation.

Prior to joining Icagen, Mr. Cunningham was an executive with one of the world’s largest pharmaceutical companies, Boehringer Ingelheim, where he held a variety of key strategic and operational roles, including the launch of Boehringer’s first entrance into the oncology market with Gilotrif (afatinib), an oral tyrosine kinase inhibitor, as a treatment for patients with non-small cell lung cancer.

In addition, Mr. Cunningham excelled in the National Football League holding All-Pro honors for the Dallas Cowboys. His career in the NFL spanned from 1994 until his retirement in 2002.

"TYME is positioned for success and I look forward to working with the leadership team and TYME employees to achieve its strategic short- and long-term objectives. I am excited about the prospects of making a positive impact in the lives of patients and enhancing the value for all stakeholders," said Richie Cunningham.

On November 30, 2020 Agilent Technologies Inc. (NYSE: A) reported the launch of the Biomarker Pathologist Training Program, a global initiative created to empower pathologists to score biomarkers accurately and confidently (Press release, Agilent, NOV 30, 2020, View Source [SID1234571992]). Developed by Agilent – a worldwide leader in developing and commercializing diagnostic products – this training program incorporates Agilent’s unique expertise in companion diagnostics and partnership with top pharmaceutical companies.

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"This program will allow pathologists to learn and practice scoring techniques, to gain the necessary confidence and competence to accurately score biomarker cases in their own laboratories. Combined with Agilent’s high-quality pathology staining solutions this training program will help ensure pathologists can score cases with high concordance."

Biomarker testing has profoundly influenced the practice of both pathology and oncology today. Targeted therapies have seen more than 30% increase from 2019, and more than 50% of targeted therapies currently in clinical trials are being co-developed with a predictive biomarker [1][2]. The Agilent Biomarker Pathologist Training Program will enable pathologists to gain confidence with scoring methodologies to enable the pursuit of the right treatment for patients.

"We are excited to successfully launch the Agilent Biomarker Pathologist Training Program to further support our efforts in the fight against cancer," said Simon Oestergaard, general manager and vice president of Pathology at Agilent. "This program will allow pathologists to learn and practice scoring techniques, to gain the necessary confidence and competence to accurately score biomarker cases in their own laboratories. Combined with Agilent’s high-quality pathology staining solutions this training program will help ensure pathologists can score cases with high concordance."

The program, which will initially be available in Europe and North America, followed by China and Asia, utilizes a digital platform, Pathcore Scholar, where attendees can navigate both standard and challenging cases. For Agilent products with approved indications, the training, supports Agilent biomarkers only and will provide strategies and best practices for delivering optimal scoring results, which will in turn improve patient outcomes. Training will be offered at different levels, from basic to advanced, and both in-person and remotely, to address individual training requirements.

On November 30, 2020 PureTech Health plc (LSE: PRTC, Nasdaq: PRTC) ("PureTech" or the "Company"), a clinical-stage biotherapeutics company dedicated to discovering, developing and commercializing highly differentiated medicines for devastating diseases, reported that it will host its first R&D Day on Friday, December 11, 2020, beginning at 9:00 a.m., Eastern Time (Press release, PureTech Health, NOV 30, 2020, View Source [SID1234571991]). The virtual program will showcase PureTech’s scientific leadership in lymphatics and related immune pathways and share insights across its Wholly Owned Pipeline, which includes LYT-100, a clinical-stage anti-fibrotic and anti-inflammatory product candidate being advanced for the potential treatment of interstitial lung diseases and lymphedema, and LYT-200, a product candidate targeting foundational immunomodulatory mechanisms for the potential treatment of solid tumors.

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In addition to presentations by PureTech’s senior team, the R&D Day will feature talks from renowned scientists and physicians, including:

Toby Maher, M.D., professor of clinical medicine and director of interstitial lung disease at Keck School of Medicine of the University of Southern California
Siddhartha Mukherjee, M.D., DPhil, clinician and researcher at Columbia University and Pulitzer Prize-winning author of The Emperor of all Maladies and The Gene
Stanley Rockson, M.D., Allan and Tina Neill professor of lymphatic research and medicine at Stanford University; chief of consultative cardiology and director of the Stanford Center for Lymphatic and Venous Disorders
Zev Wainberg, M.D., co-director of the UCLA GI Oncology Program and assistant professor of medicine at UCLA
"PureTech’s inaugural R&D Day is an opportunity to bring together field-leading experts within our expansive global network to discuss the unique therapeutic opportunities within lymphatics and related immunology," said Daphne Zohar, chief executive officer of PureTech Health. "We have made great progress across our Wholly Owned Pipeline, which now includes four product candidates and three discovery platforms, and we look forward to detailing our differentiated approach towards addressing major diseases."

The agenda for PureTech’s R&D Day is:

Opening Remarks

Welcome from Chris Viehbacher, chairman of PureTech Board of Directors, and Bob Horvitz, Ph.D., chairman of PureTech R&D Committee
Perspectives from Daphne Zohar
Lymphatic Science Overview

The science underlying our Wholly Owned Pipeline, including the biology of the BIG Axis, lymphatic system and related immunology: Joe Bolen, Ph.D., chief scientific officer at PureTech
A clinical perspective on lymphatics and the need for innovation in lymphatic disorders and beyond: Stanley Rockson, M.D. (includes Q&A)
Fibrotic and Inflammatory Conditions – Unmet Need and LYT-100

Deep dive into LYT-100 and its potential to treat a range of conditions involving fibrosis, inflammation and impaired lymphatic flow: Michael Chen, Ph.D., head of innovation at PureTech
A pulmonology perspective on interstitial lung diseases, including IPF and Long COVID, and the unmet need: Toby Maher, M.D., Ph.D. (includes Q&A)
Remarks from Eric Elenko, Ph.D., chief innovation officer at PureTech
Immuno-Oncology – Prioritizing Targets and Future Directions

Perspectives on the field of immuno-oncology, where we are today and the clinical landscape: Siddhartha Mukherjee, M.D., DPhil, and Zev Wainberg, M.D.
Deep dive into LYT-200 and targeting galectin-9 for a range of cancer indications: Aleksandra Filipovic, M.D., Ph.D., head of oncology at PureTech
Fireside chat: What’s next? The future of immuno-oncology with Drs. Zev Wainberg and Siddhartha Mukherjee (includes Q&A)
Closing Remarks

PureTech’s vision for future growth and Q&A session with the PureTech senior management team
A webcast of the event will be available on the Investors section of PureTech’s website under Events & Presentations.