Amyris Raises $200 Million From Private Placement

On June 4, 2020 Amyris, Inc. (Nasdaq: AMRS), a leading synthetic biotechnology company in Clean Health and Beauty markets through its consumer brands and a top supplier of sustainable and natural ingredients, reported that it has successfully executed a binding funding agreement with leading institutional investors to raise $200 million at $3.00 per common share through a private investment in public equity (PIPE) in the Company (Press release, Amyris Biotechnologies, JUN 4, 2020, View Source [SID1234560854]). The offering includes 49% of common stock and 51% of preferred stock, convertible into common stock following stockholder approval. The private investment is subject to customary closing conditions.

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The investment is being made by a consortium of high quality institutional and accredited investors and mutual funds with expertise in health care, biotechnology or a consumer orientation consisting of approximately 70% new investors and 30% existing investors.

Following closing of the investment, the Company expects to use the proceeds from the offering for general corporate purposes and to repay certain outstanding indebtedness by approximately $61 million to lower total debt to about $162 million. Of this reduction, $24 million is from conversions to equity and, thus, not from using proceeds from the transaction. The reduced debt results in significantly lower future debt servicing expense.

"We are very excited to have obtained funding that will enable us to execute our strategic priorities, support business growth, further reduce debt and simplify our balance sheet and help us attain positive cash flow from operations," said Han Kieftenbeld, Chief Financial Officer.

"We believe that this financing positions us very well for continued industry leading revenue growth with our consumer brands and ingredients portfolio, toward our goal of profit and positive cash generation. We are committed to strong value generation for shareholders while making our planet healthier," commented John Melo, President and Chief Executive Officer.

Jefferies LLC and Cowen and Company LLC served as joint lead placement agents for the financing. Oppenheimer & Co. Inc. served as co-placement agent.

The securities to be sold in the private placement have not been registered under the Securities Act of 1933, as amended, or any state or other applicable jurisdiction’s securities laws, and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act and applicable state or other jurisdictions’ securities laws. The Company has agreed to file a registration statement with the U.S. Securities and Exchange Commission (the "SEC") registering the resale of the shares of common stock sold in the private placement and the shares of common stock issuable upon exercise of the preferred stock.

TVAX Biomedical Receives Fast Track Designation from the FDA for Brain Cancer

On June 4, 2020 TVAX Biomedical reported that receipt of Fast Track Designation from the U.S. Food and Drug Administration (FDA) for the use of its vaccine-enhanced adoptive T cell therapy (VACT) for treatment of glioblastoma multiforme, a deadly form of brain cancer (Press release, TVAX Biomedical, JUN 4, 2020, View Source [SID1234560853]).

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"We are very pleased to receive Fast Track Designation by the FDA for glioblastoma multiforme (GBM)," stated Dr. Wayne Carter, Chief Executive Officer. "Glioblastoma is a devastating disease for which there are limited treatment options."

FDA Fast Track Designation is designed to accelerate marketing approval of therapies aimed at treating serious and life-threatening diseases. The Designation creates an opportunity for close and regular communication between TVAX Biomedical and the FDA in order to improve the efficiency of product development. Additionally, it provides a pathway for accelerated approval and rolling review of completed Biological Licensing Application sections by the FDA.

TVAX Biomedical has completed Phase 1 and 2a studies in multiple cancers, including GBM. Significant benefit was demonstrated in GBM patients using TVAX’s patented VACT in those studies. TVAX’s currently planned studies will evaluate VACT in newly diagnosed GBM patients who have healthy immune systems and minimal disease at a time when VACT would be anticipated to generate maximal efficacy.

Alkermes to Take Part in 41st Annual Goldman Sachs Global Healthcare Conference

On June 4, 2020 Alkermes plc (Nasdaq: ALKS) reported that management will participate in a fireside chat at the 41st Annual Goldman Sachs Global Healthcare Conference on Thursday, June 11, 2020 at 9:40 a.m. ET (2:40 p.m. BST) (Press release, Alkermes, JUN 4, 2020, View Source [SID1234560852]). The webcast may be accessed under the Investors tab on www.alkermes.com and will be archived for 14 days.

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Neurocrine Biosciences to Present at the Goldman Sachs 41st Annual Global Healthcare Conference Webcast

On June 4, 2020 Neurocrine Biosciences, Inc. (Nasdaq: NBIX) reported that it will present at the Goldman Sachs 41st Annual Global Healthcare Conference Webcast at 9:40 a.m. ET on Thursday, June 11, 2020 (Press release, Neurocrine Biosciences, JUN 4, 2020, View Source [SID1234560851]). Kevin Gorman, Chief Executive Officer, Eiry Roberts, Chief Medical Officer, and Kyle Gano, Chief Business Development and Strategy Officer, will present at the conference.

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The live presentation will be webcast and may be accessed on the Company’s website under Investors at www.neurocrine.com. A replay of the presentation will be available on the website approximately one hour after the conclusion of the event and will be archived for approximately one month.

NuVasive, Inc. Announces Full Exercise Of Option By Initial Purchasers To Purchase Additional 1.00% Convertible Senior Notes Due 2023

On June 4, 2020 NuVasive, Inc. (NASDAQ: NUVA) reported that it closed the issuance of an additional $50.0 million in aggregate principal amount of the 1.00% Convertible Senior Notes due 2023 (the "Convertible Notes"), pursuant to the exercise in full of the initial purchasers’ option to purchase such additional notes (the "Option Notes") in connection with the previously announced Convertible Notes offering that closed on June 1, 2020 (Press release, NuVasive, JUN 4, 2020, View Source;301070982.html [SID1234560850]).

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The Option Notes have the same terms as the Convertible Notes. The Option Notes were issued under the same Indenture as the Convertible Notes dated as of June 1, 2020 between the Company and Wilmington Trust, National Association, as trustee, which terms are described in the Company’s Current Report on Form 8-K filed on June 1, 2020.

The sale of the Option Notes to the initial purchasers settled on June 4, 2020, subject to customary closing conditions, and resulted in approximately $48.6 million in net proceeds to NuVasive (in addition to the previously announced net proceeds of $387.5 million from the initial closing of the offering of the Convertible Notes on June 1, 2020) after deducting fees and estimated offering expenses payable by NuVasive.

In addition, in connection with the issuance of the Option Notes, NuVasive entered into privately negotiated additional convertible note hedge transactions and additional warrant transactions with certain dealers, including affiliates of certain of the initial purchasers of the Convertible Notes and other financial institutions (the "Option Counterparties"). The additional convertible note hedge transactions and the additional warrant transactions are on substantially similar terms as the base convertible note hedge transactions and base warrant transactions entered into on May 27, 2020 with the Option Counterparties.

NuVasive intends to use approximately $2.5 million of the net proceeds from the offering of the Option Notes to pay the cost of the additional convertible note hedge transactions (after such cost is partially offset by the proceeds to NuVasive from the additional warrant transactions). NuVasive intends to use the remaining net proceeds for working capital and other general corporate purposes, which may include potential mergers and acquisitions, to refinance indebtedness and for repurchases of outstanding Convertible Senior Notes due 2021 (the "2021 Notes"). Any repurchase of the 2021 Notes could have the effect of raising or maintaining the market price of NuVasive’s common stock above levels that would otherwise have prevailed, or preventing or retarding a decline in the market price of NuVasive’s common stock, and thereby impacting the trading price of the Convertible Notes.

The offering of the Option Notes is only being made to qualified institutional buyers pursuant to Rule 144A under the Securities Act. Neither the Option Notes nor any shares of NuVasive’s common stock issuable upon conversion of the Option Notes have been or are expected to be registered under the Securities Act or under any state securities laws and, unless so registered, may not be offered or sold in the United States except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and applicable state securities laws.