On November 2, 2020 Trained Therapeutix Discovery, Inc. ("TTxD"), an immunotherapy biotech company founded by Jean Boulle Therapeutics, reported that the results of a preclinical Study ("the Study") published in Cell showing how nanobiologic immunotherapy promotes trained immunity and elicits a durable anti-tumor response either as a monotherapy or in combination with other checkpoint inhibitor drugs (Press release, Trained Therapeutix Discovery, NOV 2, 2020, View Source [SID1234569659]).
TTxD’s scientific founders Willem Mulder, Zahi Fayad, Jordi Ochando, Leo Joosten and Mihai Netea were all co-authors of the Study which involved scientists from 23 research institutions around the world. The Study shows for the first time how trained immunity can be therapeutically exploited to help fight cancers.
In the Study, the researchers developed a library of nanobiologics (nanomaterials bioengineered from molecules that exist naturally within the body) designed specifically to induce trained immunity in bone marrow cells. Through extensive screening, involving in vitro training assays and in vivo mouse biodistribution experiments, the Study identified a bone marrow-avid nanobiologic lead candidate, named MTP10-HDL.
MTP10-HDL was shown to have potent anti-tumor capabilities in a B16F10 mouse melanoma model. These capabilities resulted from changes to the way in which the bone marrow produced infection fighting cells (myelopoiesis) that were induced by trained immunity. The Study also showed MTP10-HDL’s favorable biodistribution and safety profile in non-human primates. This technology has been exclusively licensed to Trained Therapeutix Discovery, Inc.
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TTxD applies advanced bioengineering methods to develop nanobiologic therapeutics that regulate the innate immune system with materials that are inherently well tolerated by the body. This pioneering approach has potential applications in the treatment of cancer, respiratory infections, autoimmune disorders, and organ transplant rejection.
Commenting on the paper, Willem Mulder, PhD scientific founder of TTxD said:
"This Study is further evidence of the huge potential that trained immunity has to fight a wide range of serious conditions. The identification of a nanobiologic material that can induce a durable anti-tumor response has the potential to open up a new horizon in cancer therapy."
Leighton Durham, Director of Jean Boulle Medtech and Co-CEO of TTxD, said:
"This study, although early stage, provides further support for TTxD’s approach and shows the potential power of trained immunity. The TTxD team is focused on further developing its revolutionary nanobiologic technologies and saving lives across a spectrum of illnesses."
Further information is available from the Eindhoven University of Technology.
Full paper: B. Priem et al., "Trained immunity-promoting nanobiologic therapy suppresses tumor growth and potentiates checkpoint inhibition", CELL, (2020).