Aurinia Pharmaceuticals to Release Fourth Quarter and Year End 2020 Financial Results on February 24, 2021

On February 17, 2021 Aurinia Pharmaceuticals Inc. (NASDAQ: AUPH / TSX: AUP) (the "Company") reported that it will release its fourth quarter and year end 2020 financial results on Wednesday, February 24, 2021, after the markets close (Press release, Aurinia Pharmaceuticals, FEB 17, 2021, View Source [SID1234575170]). Aurinia’s management team will host a conference call to discuss the Company’s financial results and to provide a general business update.

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The conference call and webcast is scheduled for February 24, 2021 at 4:30pm ET. In order to participate in the conference call, please dial +1-877-407-9170 (Toll-free U.S. & Canada). An audio webcast can be accessed under "News/Events" through the "Investors" section of the Aurinia corporate website at www.auriniapharma.com. A replay of the webcast will be available on Aurinia’s website.

Theragnostics Announces a research collaboration with Essen University Hospital to study THG-008 for Oncology PET Imaging

On February 17, 2021 Theragnostics, which is developing molecular radiotherapy for imaging and treating a broad range of cancers, reported a research collaboration with Essen University Hospital to examine Theragnostics’ investigational agent THG-008 for PET imaging in a range of cancers (Press release, Theragnostics, FEB 17, 2021, View Source;utm_medium=rss&utm_campaign=theragnostics-announces-a-research-collaboration-with-essen-university-hospital-to-study-thg-008-for-oncology-pet-imaging [SID1234575169]).

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The research is due to start in February 2021 and will be led by Dr. Michael Nader, head of radiochemistry and part of the Clinic for Nuclear Medicine at Universitätsklinikum Essen (University Hospital Essen), in Germany.

THG-008 is a novel fluorine-18 radiolabelled PARP inhibitor (18F-PARPi) which has a number of applications relevant to imaging cancer. A Phase 1 clinical study for THG-008 in head and neck squamous cell carcinoma (HNSCC) completed recruitment in May 2019. Data published in a peer-reviewed publication confirmed imaging of head and neck cancer with 18F-PARPi was feasible and had an acceptable safety profile.1 The study also confirmed that 18F-PARPi can detect primary and metastatic HNSCC lesions, and that retention in cancer deposits was longer than in healthy tissues.

Commenting on the collaboration, Greg Mullen, Chief Executive Officer of Theragnostics, said: "We are excited to collaborate with Professor Dr Ken Herrmann, who has extensive experience in Nuclear Medicine and is an important researcher in the field. Radiolabelled PARP inhibitors have the potential to improve patient survival in a number of cancers. There are several approved conventional pharmaceutical PARP inhibitors on the market with new indications being approved in recent months further expanding an existing multibillion dollar market."

Professor Dr. Ken Herrmann added: "Universitätsklinikum Essen specialises in the diagnosis and treatment of cancer using nuclear medicine techniques which puts us in a privileged position to assess and evaluate the potential of THG-008 as a PET imaging agent. With this study we hope to advance our understanding of the applicability of PARP inhibitor imaging oncology."

Innate Pharma to participate in the 10th Annual SVB Leerink Global Healthcare Conference

On February 17, 2021 Innate Pharma SA (Euronext Paris: IPH – ISIN: FR0010331421; Nasdaq: IPHA) ("Innate" or the "Company") reported that members of its senior management team are scheduled to participate in the following upcoming virtual investor conference (Press release, Innate Pharma, FEB 17, 2021, View Source [SID1234575168]):

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10th Annual SVB Leerink Global Healthcare Conference
Event Date: February 24-26, 2021
Fireside Chat: February 24, 2021 at 2:00-2:30 p.m. CET / 8:00-8:30 a.m. ET

A live webcast of the fireside chat will be available through the News & Events page of the Investors section of the Company’s website at www.innate-pharma.com. An archived replay of the webcast will be available for approximately 90 days following the presentation.

Micronoma Raises $3.5 Million in Convertible Note Financing

On February 17, 2021 Micronoma, the first cancer detection biotech company that utilizes signals from the tumor-related microbiome to diagnose cancer at an early stage with liquid biopsy technology, reported the closing of $3.5 million in convertible debt financing (Press release, Micronoma, FEB 17, 2021, View Source [SID1234575167]). The contributions came from existing investor, US-based SymBiosis, LLC, and new European investor, The Seerave Foundation. The investments bring Micronoma’s total amount of funding to $6.5 million since the company’s first seed round six months ago.

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Micronoma decrypts signals from some of the most ancient matter in the world, the microbiome, to detect cancer early, from all genomes. The additional financing will enable Micronoma to complete its validation study on lung cancer prediction, set up CLIA (Clinical Laboratory Improvement Amendments) operations, establish its go-to-market strategy utilizing its Oncobiota platform, and initiate work on a second cancer target.

"The Seerave Foundation is a strong supporter of efforts enabling personalized cancer treatments. We are confident that the nutrition-microbiome-immune system axis is a significant factor in each patient’s journey," said David Rees, founder of The Seerave Foundation. "Thus, we recognize early diagnosis of cancer-associated microbial DNA as a key element to transforming cancer diagnostics and treatment going forward. We are convinced that the Micronoma platform will complement our other research activities and help in translating scientific innovations for practical applications. We are interested in being able to enhance the standard of care with a more holistic and patient-centric approach. Our ultimate goal is to move from a therapeutic into a preventive setting of personalized medicine which is where Micronoma’s innovation and expertise come into play, to empower physicians with actionable biomarkers."

Micronoma’s promising research was published in Nature last year, showing unique predictive microbial signatures in tissue and blood for most major types of cancer. Accurate, early cancer detection via liquid biopsy remains a challenge that Micronoma may be able to solve through its proprietary Oncobiota platform. Though having the potential to be a pan-cancer diagnostic tool, Micronoma will start with lung cancer, and with this recent funding, move toward pancreatic cancer diagnostics.

"We are grateful for the continued and new support from like-minded organizations that are as dedicated as we are to finding innovative and precise ways to significantly improve early cancer diagnosis," said Sandrine Miller-Montgomery, CEO of Micronoma. "SymBiosis has been an amazing partner and we are so happy to now have Seerave, expanding our support globally. Together, we can expand the limits of care and revolutionize what practitioners and patients have come to understand as status quo. We are all very passionate about bringing this technology to market as quickly and thoroughly as possible."

Each year, there are approximately 18 million new cancer cases worldwide and nine million cancer deaths. It is estimated that with early detection, up to 4 million of those deaths could be prevented every year. The diagnostic implications of microbiome markers in liquid and tissue biopsies are extensive, and Micronoma is prepared to lead the way on helping prevent unnecessary suffering caused by later-stage cancer diagnosis.

Nanocan Therapeutics Corporation Announces Exclusive Global Licensing Agreement for Immunogenic Smart Radiotherapy Biomaterials

On February 16, 2021 Nanocan Therapeutics Corporation, an early-stage biotechnology company, reported an exclusive global licensing agreement with Brigham and Women’s Hospital (Boston, MA), a teaching hospital of Harvard University’s Medical School, to develop and commercialize Immunogenic Smart Radiotherapy Biomaterials (iSRBs) for the treatment of pancreatic, lung, and cervical cancer (Press release, Nanocan Therapeutics, FEB 16, 2021, View Source [SID1234625677]). This technology has the potential to enhance radiotherapy mechanisms via delivery of immunoadjuvants that improve both local and metastatic tumor kill. iSRBs could also potentially reduce treatment time and cost for cancer patients, improve convenience, and significantly improve global patient access to cancer treatment.

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iSRBs can provide both CT and MRI imaging contrast crucial for image-guided radiotherapy and can also provide sustained delivery of immunoadjuvant payloads. In conjunction with an immunoadjuvant, a boost in abscopal effect causing regression in both treated and untreated tumors has been observed in animal models, with minimal normal tissue toxicity.

"Pancreatic cancer, our lead indication, remains a challenging diagnosis with high mortality," said Eric Broyles, Founder and CEO of Nanocan Therapeutic Corporation. "With our expertise in nanotechnology delivery, and grant investments from the NIH, NCI, and DoD, Nanocan is well positioned to further develop iSRBs in pursuit of providing a new standard of care for pancreatic, lung, and cervical cancers. We also see potential application in breast, liver, and prostate cancers, as well as glioblastoma."

We’re encouraged by the research undertaken by scientists at Brigham and Women’s Hospital and excited about this global licensing agreement," said Jack Markell, two-term Governor of Delaware and Nanocan Advisory Board member. "We are deeply committed to improving the lives of cancer patients around the world and will place a special emphasis on bringing these life-saving technologies to underserved and developing countries."