Seelos Therapeutics Announces Closing of $7.0 Million Registered Direct Offering

On September 9, 2020 Seelos Therapeutics, Inc. (Nasdaq: SEEL), a clinical-stage biopharmaceutical company, reported that it has closed its previously announced registered direct offering to certain institutional investors of 8,865,000 shares of common stock at a price of $0.79 per share (Press release, Apricus Biosciences, SEP 9, 2020, View Source [SID1234564822]). The Company also closed its previously announced concurrent private placement to the investors of unregistered warrants to purchase up to 6,648,750 shares of common stock. The warrants have an exercise price of $0.84 per share of common stock, will be exercisable six months from the date of issuance and will expire five years following the initial date of exercise.

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After deducting the placement agent’s fees and offering expenses, the Company received net proceeds of approximately $6.2 million. Seelos intends to use the net proceeds from the offering for general corporate purposes and to advance the development of its product candidates.

Roth Capital Partners acted as the sole placement agent for the offering.

A shelf registration statement on Form S-3 (File No. 333-221285) relating to the shares of common stock issued in the registered direct offering was previously filed with the Securities and Exchange Commission (the "SEC") on November 2, 2017, amended on December 1, 2017 and declared effective by the SEC on December 7, 2017. Such shares were offered only by means of a prospectus. A prospectus supplement and the accompanying prospectus relating to and describing the terms of the registered direct offering has been filed with the SEC and is available on the SEC’s website at www.sec.gov. Copies of the prospectus supplement and the accompanying prospectus relating to the registered direct offering may also be obtained by contacting Roth Capital Partners, LLC, 888 San Clemente Drive, Newport Beach, California 92660, by calling (800) 678-9147 or by e-mail at [email protected].

The unregistered warrants described above were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act"), and Regulation D promulgated thereunder and, along with the shares of common stock underlying the warrants, have not been registered under the Act or applicable state securities laws. Accordingly, the warrants and underlying shares of common stock may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Act and such applicable state securities laws.

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

Constellation Pharmaceuticals to Participate in Upcoming Virtual Investor Conferences

On September 9, 2020 Constellation Pharmaceuticals, Inc. (Nasdaq: CNST), a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics, reported that the Company will participate in upcoming virtual investor conferences (Press release, Constellation Pharmaceuticals, SEP 9, 2020, View Source [SID1234564821]). Jigar Raythatha, CEO, will present at:

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The H.C. Wainwright Global Investment Conference at 1:00 PM EDT on September 14
The Cantor Global Healthcare Conference at 1:20 PM EDT on September 17
Live audio webcasts of Mr. Raythatha’s presentations and archives for replay will be available on the Investor Relations section of Constellation’s website at View Source The audio webcast replays will be available for 30 days following the live presentation.

Surface Oncology to Present at the Baird Global Healthcare Conference

On September 9, 2020 Surface Oncology (Nasdaq:SURF), a clinical-stage immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, reported that Jeff Goater, its chief executive officer, and Robert Ross, M.D., its chief medical officer, will present at the upcoming Robert W. Baird Global Healthcare Conference, discussing Surface Oncology’s lead programs, SRF617 (targeting CD39) and SRF388 (targeting IL-27) as well as Surface’s emerging pre-clinical pipeline, highlighted by SRF813 (targeting CD112R, aka PVRIG) (Press release, Surface Oncology, SEP 9, 2020, View Source [SID1234564820]).

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The presentation will be in the format of a fireside chat and take place virtually on Thursday September 10, 2020 at 1:25 pm EDT.

Summit Biomedical Imaging Signs Agreement with Theragnostics Enabling the Development of Novel Fluorescence-Based Cancer Diagnostics

On September 9, 2020 Summit Biomedical Imaging ("SBI"), a private, clinical-stage company developing products for diagnostic medical imaging and Theragnostics, which is developing molecular radiotherapy for imaging and treating a broad range of cancers, reported their entering into a global license agreement for intellectual property (IP) that will contribute to SBI’s global freedom to operate in the diagnostic field of certain fluorescence-labeled PARP (Poly ADP-Ribose Polymerase) inhibitors (Press release, Theragnostics, SEP 9, 2020, View Source [SID1234564818]).

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SBI’s cancer detection technology uses PARPi-FL, a PARP inhibitor with a fluorescence tag. PARP is a class of enzymes that are involved in normal cellular processes including DNA damage repair. PARP activity and expression are up-regulated in tumor cells. PARP inhibitors block the action of PARP by binding to PARP enzymes.

PARPi-FL combines the ability to bind to PARP with a fluorescence tag to specifically target cancers that over-express PARP. By targeting PARP, PARPi-FL brings the optical imaging agent to the cancer, enabling direct detection of tumors with significantly greater selectivity and sensitivity as compared to other competing technologies.

Andrew Riley, Chief Executive Officer of Summit Biomedical Imaging, said: "This agreement with Theragnostics bolsters Summit Biomedical Imaging’s IP position with regards to PARPi-FL and will allow Summit Biomedical Imaging to focus on developing the oral cancer detection application for this molecule. This will enable Summit Biomedical Imaging to bring new diagnostic solutions to market for detecting cancer earlier and improving patient outcomes."

Dr. Gareth Smith, Chief Operating Officer of Theragnostics, added: "Theragnostics is pleased to work with Summit Biomedical Imaging for the development of PARP inhibitor based diagnostics. Leveraging their expertise in oncological diagnostics applications is an important step forward in implementing our strategy of bringing novel diagnostic agents and new targeted therapies to cancer patients."

SBI’s first target for this technology is the in vivo detection of oral cancer, a large and growing market. Worldwide, over 450,000 cases of oral cancer are diagnosed each year and in many places, including the United States, the incidence rate of oral cancer is increasing. Oral cancer detection is estimated to be a $5 billion market (source, Market Research Future), which is projected to grow over 6.8% annually through 2024. Summit Biomedical Imaging seeks to enable earlier diagnosis using PARPi-FL and fluorescence imaging in the oral cavity. Earlier detection enables earlier intervention, which corresponds to saving lives and lower intervention costs, with the potential to save over $1 billion in patient and insurance costs annually.

TG Therapeutics to Present at Upcoming Investor Conferences

On September 9, 2020 TG Therapeutics, Inc. (NASDAQ: TGTX) reported its participation at two upcoming virtual investor conferences. Michael S. Weiss, the Company’s Executive Chairman and Chief Executive Officer, is scheduled to participate in fireside chats during the following conferences (Press release, TG Therapeutics, SEP 9, 2020, View Source [SID1234564817]):

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The H.C. Wainwright 22nd Annual Global Investment Conference – fireside chat scheduled to take place on Monday, September 14, 2020 at 1:30 PM ET
The Cantor Fitzgerald Global Healthcare Conference – fireside chat scheduled to take place on Wednesday, September 16, 2020 at 10:40 AM ET
A live webcast of each presentation will be available on the Events page, located within the Investors & Media section, of the Company’s website at View Source