On July 28, 2020 Clarity Pharmaceuticals, a radiopharmaceutical company focused on the treatment of serious disease,reported that the first patient has been treated in the C-BOBCAT study (Copper-64 BOmbesin in Breast CAncer Trial) (Press release, Clarity Pharmaceuticals, JUL 28, 2020, View Source [SID1234562447]).

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The C-BOBCAT trial is a first-in-human, investigator-led clinical trial investigating 64Cu-SAR-Bombesin (SAR-BBN) in patients with hormone receptor positive/HER2 negative (HR+/HER2-) metastatic breast cancer. The trial is led in collaboration with Associate Professor Louise Emmett, Director of Theranostics and Nuclear Medicine, at St Vincent’s Hospital in Sydney.

Bombesin is a natural homolog to the mammalian gastrin-releasing peptide, which is able to specifically bind to the gastrin-releasing peptide receptor (GRPr). GRPr is present on the membrane of most prostate, breast, ovarian and small cell lung cancers, gastrointestinal stromal tumours, and in tumoural vessels of urinary cancers. In relation to breast cancer, HR+/HER2- breast cancers make up roughly 67%1 of new breast cancer cases diagnosed each year, affecting roughly 181,000 women in 2019 in the USA2 alone, and approximately 13,000 women in Australia3.

Clarity’s Executive Chairman, Dr Alan Taylor, said, "We are excited to commence this trial as SAR-BBN is Clarity’s second product after SARTATE to enter the clinical development stage. We are looking forward to progressing this study with our collaborators at St Vincent’s Hospital in Sydney, who have been involved in some pioneering radiopharmaceutical studies in recent times. We hope that SAR-BBN will allow for Positron Emission Tomography (PET) imaging and localisation of metastatic breast cancer lesions that express GRPr, and we look forward to utilising that data to progress SAR-BBN into other diagnostic and therapeutic trials in a range of cancers that express GRPr with our ultimate goal of better treating children and adults with cancer."

References
American Cancer Society, Surveillance Research (2017)
National Cancer Institute, Cancer Stat Facts: Female Breast Cancer, View Source
Australian Government Cancer Statistics, Breast cancer in Australia statistics, View Source

On July 28, 2020 Alentis Therapeutics, the Swiss biotech developing breakthrough treatments for fibrotic diseases, reported that Dr. Roberto Iacone, has been named Chief Executive Officer (Press release, Alentis Therapeutics, JUL 28, 2020, View Source [SID1234562446]).

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Dr. Iacone is a physician-scientist, a serial entrepreneur and brings more than 15 years life science industry experience to Alentis. Most recently while at Versant Ventures, he co-founded Bright Peak Therapeutics and Ridgeline Therapeutics, and was part of the leadership team that built the precision oncology company Black Diamond Therapeutics from inception through to its NASDAQ IPO in three years. Prior to Versant, Roberto was Roche’s Global Head of Rare Diseases Research, where he established numerous collaborations with academic and biotech partners, which included large and small molecule as well as gene therapy programs.

Welcoming Dr Iacone to the company, Neil Goldsmith, Chairman of the Board of Alentis Therapeutics, said: "Alentis has developed significantly in our first year, with excellent progress in our understanding of the role of Claudin-1 as a novel therapeutic target in fibrosis and hepatobiliary cancers. We have taken major strides in Chemistry and Manufacturing Control (CMC) for our first product, and its safety profile appears very encouraging from the pilot studies conducted to date. We are delighted that Roberto has decided to join our cause, and look forward to further great strides from him and the team. We also would like to thank former CEO Markus Ewert for his fantastic work building the company, portfolio and team."

"We’re very excited that Roberto has joined us to lead the team as the company moves to the next level in its development," said Thomas F. Baumert MD, founder and board member of Alentis Therapeutics, Professor of Medicine and Head of the Inserm Research Institute for Viral and Liver Diseases at the University of Strasbourg. "His entrepreneurial thinking and leadership experience will rapidly advance the Alentis portfolio into the clinic addressing key unmet medical needs to improve patients’ lives and outcomes."

"The recent advances in science enable novel therapies to treat and reverse fibrosis, which is central to multiple diseases as well as several life-threatening cancers such as hepatocellular carcinoma and cholangiocarcinoma," said Dr. Iacone. "Alentis has developed a tremendous portfolio and platform to develop breakthrough treatments for fibrotic diseases."

He added that following the foundation of the company one year ago, the development of Alentis’ lead compound has markedly advanced with completed preclinical in vivo proof-of-concept studies for liver and kidney fibrosis, fibrosis-driven hepatobiliary cancer and extensive safety studies.

"As we now transition towards a clinical-stage company, I look forward to working with the team and board, our collaborators, and the investors, to realise the potential benefit for patients," said Dr. Iacone.

"Roberto’s expertise in developing drugs in biotech, pharma and VC will be most valuable in effectively translating Alentis Therapeutics’ most promising research and its assets into clinical benefit for patients as well as commercial value," said Dr. A. Wallnöfer, General Partner at BioMed Partners VC and former Head of Clinical Research & Exploratory Development at F. Hoffmann-La Roche.

Roberto holds an M.D. from the University of Naples, and a PhD from the Max Planck Research School for Molecular Cell Biology and Genetics.

On July 28, 2020 Propanc Biopharma, Inc. (OTC: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing new cancer treatments for patients suffering from recurring and metastatic cancer, reported that the company received an additional investment tranche from a lead institutional investor to support company operations and working capital needs (Press release, Propanc, JUL 28, 2020, View Source [SID1234562437]). To date, a, total of $550,000 has been funded by the institutional investor of a $3,000,000 financing agreement, as the company prepares its lead product candidate, PRP, for a Phase IB, First-In-Human study, in advanced cancer patients suffering from solid tumors.

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"We are pleased to receive ongoing financial support from our lead institutional investor as we transition PRP into the clinic," said Carlo Campiciano, Propanc’s Chief Financial Officer, "The investment will be utilized to support our operations, as well as preparing for undertaking R&D activities, including validation of a pharmacokinetics method and a quality assurance review, as we advance towards the finished product manufacture of PRP for our upcoming clinical study, which we hope to commence early 2021."

"We recognize and appreciate the support of our shareholders, as we undertake an important transformation to a clinical stage biopharma company," said James Nathanielsz, Propanc’s Chief Executive Officer. "With our attractive R&D tax incentive benefit for local and approved overseas activities from the Australian Government, we have an opportunity to recoup a portion of our development expenses upon the achievement of near-term development milestones for PRP," said James Nathanielsz.

On July 28, 2020 Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, reported that the Company will release its second quarter 2020 financial results on Tuesday, August 4, 2020, after the close of US markets (Press release, Curis, JUL 28, 2020, View Source [SID1234562435]). Management will host a conference call on the same day at 4:30 p.m. ET.

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To access the live conference call, please dial (888) 346-6389 from the United States or (412) 317-5252 from other locations, shortly before 4:30 p.m. ET. The conference call can also be accessed on the Curis website at www.curis.com in the ‘Investors’ section. A replay of the financial results conference call will be available on the Curis website shortly after completion of the call.

On July 28, 2020 CytomX Therapeutics, Inc. (Nasdaq: CTMX), a clinical-stage oncology-focused biopharmaceutical company pioneering a novel class of investigational antibody therapeutics based on its Probody therapeutic technology platform, reported second quarter 2020 financial results on Thursday, August 6, 2020, after the close of U.S. markets. Following the announcement, the company will host a conference call beginning at 5:30 p.m. ET to discuss the results.

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Participants may access the live audio webcast of the teleconference from the "Investors & News" section of CytomX’s website at View Source Please access the website 15 minutes prior to the start of the call to download and install any necessary audio software.

Audio Conference Call:

U.S. Dial-in Number: (877) 809-6037

International Dial-in Number: (615) 247-0221

Conference ID: 5399347
An archived webcast replay will be available on the Company’s website from August 6, 2020, until August 13, 2020.