PTC Therapeutics to Present at the Jefferies Virtual Healthcare Conference

On May 26, 2020 PTC Therapeutics, Inc. (NASDAQ: PTCT) reported that management will present a company overview at the Jefferies Virtual Healthcare Conference on Tuesday, June 2nd at 1:00 p.m. ET (Press release, PTC Therapeutics, MAY 26, 2020, View Source [SID1234558506]).

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The presentation will be webcast live on the Events and Presentations page under the investor relations section of PTC Therapeutics’ website at www.ptcbio.com and will be archived for 30 days following the presentation. It is recommended that users connect to PTC’s website several minutes prior to the start of the webcast to ensure a timely connection.

Epic Sciences to Present Multiple Abstracts at ASCO 2020 Highlighting the Importance of CTCs in Liquid Biopsy

On May 26, 2020 Epic Sciences, Inc. reported that it will present three abstracts at the 2020 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Virtual Scientific Program to be held from May 29 – June 2, 2020 (Press release, Epic Sciences, MAY 26, 2020, View Source [SID1234558505]). Epic Sciences will present new data demonstrating the role of circulating tumor cells (CTCs) in cancer prognosis and treatment outcomes.

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"These presentations underscore the unique value CTCs have in the care of patients with advanced prostate cancer," said Rick Wenstrup, MD, chief medical officer at Epic Sciences. "New data demonstrates the clear prognostic value of CTC enumeration measured by Epic’s platform; CTC counts were found to be a better predictor of one-year survival relative to other common blood-based measures including Lactate-dehydrogenase (LDH), Prostate-specific antigen (PSA) and Alkaline-phosphatase (ALK)."

"The ability of the Epic platform to delineate clinically meaningful CTC heterogeneity is further demonstrated in this case with the identification of small-cell neuroendocrine-like CTC subtypes that have selective sensitivity to platinum agents in patients with advanced prostate cancer, as well as new data that shows the unique advantages of CTC single-cell genomic analysis in identifying alterations such as BRCA2 copy loss compared to tissue-based testing," said Howard Scher, MD, Chief of Genitourinary Service at Memorial Sloan Kettering.

The data presented at this year’s ASCO (Free ASCO Whitepaper) Scientific Program complement the extensive ongoing clinical research in prostate cancer. Epic Sciences’ commercialized prostate cancer test for nuclear-localized AR-V7 assists physicians in choosing between androgen receptor-directed therapies or taxane chemotherapy for their patients with metastatic castration-resistant prostate cancer (mCRPC). Epic’s test for AR-V7 is offered by its partner, Exact Sciences, under the brand Oncotype DX AR-V7 Nucleus Detect. This test is Epic’s first test that is commercially available and reimbursed by Medicare.

Epic Science’s proprietary rare-cell-detection platform can detect one cell in 10 million cells to provide contextual analysis with spatial, morphological, cellular and genomic information. Today Epic assists more than 40 global biopharmaceutical partners by applying its unbiased, enrichment-free approach to identify and characterize circulating tumor cells in the blood samples of subjects of dozens of clinical trials across a wide range of drugs.

The following are details of the abstract virtual sessions, which are also available at www.asco.org and www.epicsciences.com.

Abstract 5531/Poster 112: Genitourinary Cancer Poster Session: Prevalence and tissue concordance of BRCA2 copy number loss evaluated by single-cell, shallow whole-genome sequencing of circulating tumor cells (CTCs) in castration-resistant prostate cancer (CRPC).

Abstract 5571/Poster 152: Genitourinary Cancer Poster Session: Clinical significance of CTC enumeration on the Epic Sciences platform in metastatic castration-resistant prostate cancer (mCRPC) patients treated with AR signaling inhibitors (ARSi).

Abstract 5572/Poster 153: Genitourinary Cancer Poster Session: Circulating tumor cells (CTCs) with small-cell like pathology are prevalent in metastatic castration-resistant prostate cancer (mCRPC) and show selective pharmacodynamic reductions in patients treated with platinum but not ARSI or taxane.

Boston Scientific to Participate in Jefferies 2020 Healthcare Conference

On May 26, 2020 Boston Scientific Corporation (NYSE: BSX) reported to participate in the Jefferies 2020 Virtual Healthcare Conference on June 2 (Press release, Boston Scientific, MAY 26, 2020, View Source [SID1234558504]).

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Joe Fitzgerald, executive vice president and president, Rhythm Management; Kenneth Stein, M.D., senior vice president and chief medical officer, Global Health Policy and Rhythm Management; Mark Bickel, vice president, controller, Rhythm Management; and Susie Lisa, vice president, Investor Relations will participate in a 25-minute question-and-answer session with the host analyst beginning at approximately 8 a.m. EDT.

A live webcast and replay of the webcast will be accessible at investors.bostonscientific.comView Source The replay will be available beginning approximately one hour following the completion of the event.

Neurocrine Biosciences to Present at the Jefferies Virtual Healthcare Conference

On May 26, 2020 Neurocrine Biosciences, Inc. (Nasdaq: NBIX) reported that it will present at the Jefferies Virtual Healthcare Conference at 11:00 a.m. ET on Tuesday, June 2, 2020 (Press release, Neurocrine Biosciences, MAY 26, 2020, View Source [SID1234558503]). Kevin Gorman, Chief Executive Officer, will present at the conference.

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The live presentation will be webcast and may be accessed on the Company’s website under Investors at www.neurocrine.com. A replay of the presentation will be available on the website approximately one hour after the conclusion of the event and will be archived for approximately one month.

NuVasive, Inc. Announces Proposed Offering Of $400 Million Of Convertible Senior Notes Due 2023

On May 26, 2020 NuVasive, Inc. (NASDAQ: NUVA) reported that it intends to offer (the "Offering"), subject to market and other considerations, $400.0 million aggregate principal amount of Convertible Senior Notes due 2023 (the "Convertible Notes") in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the "Securities Act") (Press release, NuVasive, MAY 26, 2020, View Source [SID1234558502]). NuVasive also intends to grant to the initial purchasers of the Convertible Notes a 13-day option to purchase up to an additional $50.0 million aggregate principal amount of the Convertible Notes.

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The Convertible Notes will be general unsecured obligations of NuVasive and interest will be paid semiannually in arrears on June 1 and December 1 of each year, beginning on December 1, 2020. The Convertible Notes will mature on June 1, 2023, unless earlier repurchased or converted. Prior to the close of business on the business day immediately preceding February 1, 2023, the Convertible Notes will be convertible at the option of holders only upon the satisfaction of certain conditions and during certain periods. Thereafter until close of business on the second scheduled trading day preceding maturity, the Convertible Notes will be convertible at the option of the holders at any time regardless of these conditions. Conversions of Convertible Notes will be initially settled in cash, or, if NuVasive has available and has reserved the maximum number of shares issuable under the Convertible Notes, NuVasive may settle conversions in cash, shares of NuVasive common stock or a combination thereof, at NuVasive’s election. The interest rate, initial conversion rate and other terms of the Convertible Notes will be determined at the time of the pricing of the Offering.

In connection with the Offering, NuVasive expects to enter into privately negotiated convertible note hedge transactions and warrant transactions with one or more dealers, which may include the initial purchasers of the Convertible Notes and/or their respective affiliates (the "Option Counterparties"). The convertible note hedge transactions are expected generally to reduce the potential dilution to NuVasive’s common stock upon any conversion of Convertible Notes and/or offset any cash payments NuVasive is required to make in excess of the principal amount of converted Convertible Notes, as the case may be, in each case upon conversion of the Convertible Notes. The warrant transactions could separately have a dilutive effect to the extent that the market price per share of NuVasive’s common stock exceeds the applicable strike price of the warrants. However, subject to certain conditions, NuVasive may elect to settle all or a portion of the warrants in cash.

NuVasive expects that in connection with establishing their initial hedges of these transactions, the Option Counterparties and/or their respective affiliates will enter into various derivative transactions with respect to NuVasive’s common stock and/or purchase NuVasive’s common stock in secondary market transactions concurrently with, or shortly after, the pricing of the Convertible Notes. This activity could increase (or reduce the size of any decrease in) the market price of NuVasive’s common stock or the Convertible Notes at that time. In addition, NuVasive expects that the Option Counterparties and/or their respective affiliates may modify their hedge positions by entering into or unwinding various derivatives with respect to NuVasive’s common stock and/or purchasing or selling NuVasive’s common stock or other securities of NuVasive in secondary market transactions following the pricing of the Convertible Notes and prior to the maturity of the Convertible Notes (and are likely to do so during any observation period related to a conversion of Convertible Notes). This activity could also cause or avoid an increase or a decrease in the market price of NuVasive’s common stock or the Convertible Notes, which could affect the ability of holders of Convertible notes to convert the Convertible Notes and, to the extent the activities occur during any observation period related to a conversion of the Convertible Notes, could affect the amount of cash and/or the number and value of shares of NuVasive common stock that holders will receive upon conversion of the Convertible Notes.

NuVasive intends to use a portion of the net proceeds of the Offering to pay the cost of the convertible note hedge transactions (after such cost is partially offset by the proceeds to NuVasive from the warrant transactions). If the initial purchasers exercise their option to purchase additional notes, NuVasive expects to sell additional warrants to the Option Counterparties and use a portion of the proceeds from the sale of the additional notes to enter into additional convertible note hedge transactions with the Option Counterparties.

NuVasive intends to use the remaining net proceeds of the Offering for working capital and other general corporate purposes, which may include potential mergers and acquisitions, to refinance indebtedness and for repurchases of outstanding Convertible Senior Notes due 2021 (the "2021 Notes"). Any repurchase of the 2021 Notes could have the effect of raising or maintaining the market price of NuVasive’s common stock above levels that would otherwise have prevailed, or preventing or retarding a decline in the market price of NuVasive’s common stock, and thereby impacting the trading price of the Convertible Notes.

The Offering is being made only to qualified institutional buyers pursuant to Rule 144A under the Securities Act. Neither the Convertible Notes nor any shares of NuVasive’s common stock issuable upon conversion of the Convertible Notes have been or are expected to be registered under the Securities Act or under any state securities laws and, unless so registered, may not be offered or sold in the United States except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and applicable state securities laws.

This news release does not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall it constitute an offer, solicitation or sale in any jurisdiction in which such offer, solicitation or sale is unlawful.