On October 20, 2020 Phosplatin Therapeutics LLC, a clinical stage pharmaceutical company focused on oncology therapeutics, reported that data revealing novel mechanistic attributes of its lead candidate PT-112, an immunogenic cell death (ICD) inducer under Phase 2 development, will be presented at the 32nd Symposium of the European Organisation for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI) and the American Association for Cancer Research (AACR) (Free AACR Whitepaper) taking place virtually from October 24-25 (Press release, Phosplatin, OCT 20, 2020, View Source [SID1234568682]).

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Title: PT-112, A First-In-Class Pyrophosphate-Platinum Conjugate, Selectively Targets Highly Glycolytic Tumor Cells (catalog number 188)

Abstract availability: Saturday, October 24, 2020 on EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) symposium site and on the Phosplatin Therapeutics web site

Session: New Drugs Poster Session (code 380)

Lead Author: A. Anel, University of Zaragoza /Aragón Health Research Institute, Biochemistry and Molecular and Cell Biology, Zaragoza, Spain

Building upon prior publication of the ICD effects of PT-112, the body of work to be presented is part of an effort to understand the metabolic pathways and cellular targets affected by PT-112 upstream of ICD initiation. "The data to be reported at the 32nd EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) Virtual Symposium advance the body of knowledge around PT-112’s pleiotropic mechanism of action and provide valuable information on further potential clinical applications of PT-112. As we continue our clinical study of this unique compound in patients with challenging cancers, such insights are important," said Robert Fallon, co-founder and chief executive officer, Phosplatin Therapeutics. "We are pleased to co-present this body of work under our fruitful collaboration with the Anel lab at the University of Zaragoza, Spain."

About PT-112

PT-112 is a novel small molecule conjugate of pyrophosphate that possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to dendritic cells and lead to downstream immune effector cell recruitment in the tumor microenvironment. PT-112 represents the best-in-class small molecule inducer of this immunological form of cancer cell death and is currently under Phase II development. The first in-human study of PT-112 demonstrated an attractive safety profile and evidence of long-lasting responses among heavily pre-treated patients and won "Best Poster" within the Developmental Therapeutics category at the ESMO (Free ESMO Whitepaper) 2018 Annual Congress. The novelty of PT-112’s pyrophosphate moiety also results in osteotropism, or the propensity of the drug to reach the mineralized bone. This property is of interest in cancer types that originate in or metastasize to the bone. The combination Phase Ib study of PT-112 with PD-L1 checkpoint inhibitor avelumab in solid tumors was reported in an oral presentation at the ESMO (Free ESMO Whitepaper) 2020 Virtual Congress.

On October 20, 2020 Aileron Therapeutics (Nasdaq: ALRN) reported that it will host a conference call and live webcast to discuss results from a Phase 1b proof-of-concept study of ALRN-6924 on Monday, October 26, 2020 at 8:30 a.m. ET (Press release, Aileron Therapeutics, OCT 20, 2020, http://investors.aileronrx.com/news-releases/news-release-details/aileron-therapeutics-host-conference-call-discuss-results-phase [SID1234568681]). As previously announced by Aileron, the Phase 1b clinical data will be presented in a late-breaking poster presentation during the upcoming 32nd EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) Annual (ENA 2020) Symposium on Molecular Targets and Cancer Therapeutics, being held virtually October 24 – 25, 2020. The abstract entitled, "Prevention of Chemotherapy-induced Myelosuppression in SCLC patients treated with the Dual MDM2/MDMX inhibitor ALRN-6924," (LBA96) will be presented starting Saturday, October 24 at 10:00 a.m. CEST (4:00 a.m. ET), on the ENA 2020 website.

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ALRN-6924 is the first and only chemoprotective therapy in clinical development to utilize a biomarker strategy by treating patients with p53-mutated cancers with the goal of limiting chemotherapy-induced toxicities and side effects. ALRN-6924, an investigational first-in-class MDM2/MDMX dual inhibitor, is a cell-permeating peptide drug that works intracellularly, activating wild-type p53 to selectively shield normal, healthy cells from chemotherapy in patients who harbor p53 mutations without interrupting chemotherapy’s targeting of cancer cells.

A live audio webcast of Aileron’s conference call will be available on the Investors section of Aileron’s website at View Source To access the call, please dial 877-705-6003 (domestic) or +1 201-493-6725 (international) five minutes prior to the start time and reference conference ID 13712133. The webcast will be archived on Aileron’s site for one year.

On October 20, 2020 Immunomic Therapeutics, Inc. (ITI) reported that it will be presenting at the 5th International Virtual Conference on Cancer Research & Development (Press release, Immunomic Therapeutics, OCT 20, 2020, View Source [SID1234568680]). On Monday, October 26, 2020, Chief Executive Officer at ITI, Dr. Bill Hearl, will be presenting a talk titled, "UNITE Platform, A Direct Antigen Presentation Approach in Oncology." Dr. Hearl will discuss ITI’s investigational platform technology, the company’s lead program and its preliminary data, as well as the company’s future focus.

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Panel details are as follows:

Title: UNITE Platform, A Direct Antigen Presentation Approach in Oncology

Panel Category: Cancer Immunology

Panel Date and Time: Monday, October 26, 2020 1:10-1:35 PM ET

Location: Cancer R&D Virtual Symposium

About UNITE

ITI’s investigational UNITE platform, or UNiversal Intracellular Targeted Expression, works by fusing pathogenic antigens with the Lysosomal Associated Membrane Protein 1, an endogenous protein in humans, for immune processing. In this way, ITI’s vaccines (DNA or RNA) have the potential to utilize the body’s natural biochemistry to develop a broad immune response including antibody production, cytokine release and critical immunological memory. This approach puts UNITE technology at the crossroads of immunotherapies in a number of illnesses, including cancer, allergy and infectious diseases. UNITE is currently being employed in a Phase II clinical trial as a cancer immunotherapy. ITI is also collaborating with academic centers and biotechnology companies to study the use of UNITE in cancer types of high mortality, including cases where there are limited treatment options like glioblastoma and acute myeloid leukemia. ITI believes that these early clinical studies may provide a proof of concept for UNITE therapy in cancer, and if successful, set the stage for future studies, including combinations in these tumor types and others. Preclinical data is currently being developed to explore whether LAMP1 nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and be used to create immune responses to tumor types that otherwise do not provoke an immune response.

On October 20, 2020 Kineta, Inc., a clinical stage biotechnology company focused on the development of novel immunotherapies in oncology and neuroscience, reported the presentation of new preclinical data on its VISTA antagonist antibodies at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Special Conference on Tumor Immunology and Immunotherapy (Press release, Kineta, OCT 20, 2020, View Source;utm_medium=rss&utm_campaign=kineta-presents-new-preclinical-data-on-its-vista-antagonist-antibodies-at-the-american-association-for-cancer-research-virtual-special-conference-on-tumor-immunology-and-immunotherapy [SID1234568673]).

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Thierry Guillaudeux, PhD, Vice President Immuno-oncology at Kineta, presented the new preclinical data on the company’s fully human anti-VISTA antibodies during the Innate and Adaptive Checkpoints plenary session. Key findings from the presentation include the following:

Kineta’s anti-VISTA antibodies carry unique sequences and the selected lead candidates exhibit potencies in the subnanomolar range
Kineta’s human anti-VISTA antibodies are highly specific and cross-react with cyno-VISTA but not mouse-VISTA
VISTA antagonist antibody induces strong anti-tumor response as a single agent or in combo-therapies with anti-PD-L1 or anti-CTLA-4 in CT26 tumor models
VISTA antagonist antibody activates dendritic cells in the blood and reduces MDSCs
"We are very pleased with the development of our new anti-VISTA antibody program and the selection of our lead candidates" said Thierry Guillaudeux. "VISTA is a unique immuno-oncology target for the treatment of non-immunogenic tumors, with a central role in re-programming the tumor microenvironment to turn cold tumors hot."

VISTA is a key driver of the immunosuppressive tumor microenvironment (TME) and is overexpressed on myeloid-derived suppressor cells (MDSC) and regulatory T cells (Tregs). It is a critical myeloid cell immune-checkpoint, and VISTA blockade can reprogram suppressive myeloid cells and reactivate antitumor immune function. Blocking VISTA activates an immune cell cascade that increases T cell effector functions to drive an efficient anti-tumor response. Preclinical studies have demonstrated single agent anti-VISTA activity but also demonstrate that targeting VISTA in combination with PD-1, PD-L1 or CTLA-4 can significantly improve the efficacy of those checkpoint inhibitors.

Presentation Details:

Title: Highly potent fully human anti-VISTA antibodies – A new target checkpoint inhibitor against immunosuppressive myeloid cells
Session Title: Innate and Adaptive Checkpoints
Date/Time: October 19, 2020, 2:20 PM – 2:29 PM Eastern
Presenter: Thierry Guillaudeux, PhD

On October 20, 2020 Oasmia Pharmaceutical’s CEO, Dr Francois Martelet reported that it will present at the Bio Europe’s Digital conference October 26-29, 2020 and take part in partnering meetings (Press release, Oasmia, OCT 20, 2020, View Source [SID1234568672]). The presentation will be made available on demand on the Bio Europe Digital website and accessible to attendees registered for the event. The presentation will also be uploaded onto Oasmia’s website following the event.

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