On September 28, 2020 The National Comprehensive Cancer Network (NCCN) reported the publication of new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pediatric Hodgkin Lymphoma (Press release, NCCN, SEP 28, 2020, View Source [SID1234567698]). Hodgkin lymphoma is one of the most curable forms of pediatric cancer, with long-term survival rates of 90% or higher1. However, treatment can result in potentially life-threatening or -altering long-term side effects. These new recommendations from NCCN synthesize the latest evidence and expert-consensus to make sure every child receives appropriate, but not excessive, treatment.

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"There has never been a more important time for these NCCN Guidelines than during this pandemic, when many patients need to be treated at their local institutions—even when a trial is available—due to travel and caregiver limitations," said Jamie Flerlage, MD, MS, St. Jude Children’s Research Hospital, Chair, NCCN Guidelines Panel for Pediatric Hodgkin Lymphoma. "There are many treatment options to choose from for pediatric Hodgkin lymphoma; some are better than others depending on the patient’s stage and risk group. These guidelines have information to help providers weigh the benefits and potential setbacks of various options for treating each individual. We’ll continue to update these guidelines regularly and incorporate any important new data from ongoing clinical trials."

"With so many treatment options available, it’s crucial to present all the evidence that can guide providers to the best choices for their patients," said Susan Hiniker, MD, Assistant Professor, Radiation Oncology, Stanford Cancer Institute, Vice-Chair, NCCN Guidelines Panel for Pediatric Hodgkin Lymphoma. "It can be a challenge for individual practitioners to follow and interpret all the clinical trial data. The NCCN multidisciplinary panel of experts deliberated and debated carefully to be sure we’re sharing optimal approaches that are firmly rooted in evidence."

Hodgkin lymphoma accounts for approximately 6% of all childhood cancer diagnoses in the United States, with just over 1,000 people diagnosed under the age of 20 every year.2 Nearly half of all people diagnosed with Hodgkin lymphoma in the U.S. are 35 or younger.3

"The treatment approaches for children with Hodgkin lymphoma are very different than for adults, so we really needed a separate set of guidelines for this population," said Kara Kelly, MD, Division Chief, Pediatric Hematology/Oncology, Chair of Pediatrics at Roswell Park Comprehensive Cancer Center, Chief of the Roswell Park Oishei Children’s Cancer and Blood Disorders Program, and Member, NCCN Guidelines Panel for Pediatric Hodgkin Lymphoma. "Pediatric patients have fewer competing health concerns and may tolerate higher doses, which lowers their risk of relapse. These guidelines really focus on how to strike the right balance for disease control while reducing long-term effects from the treatment."

NCCN has been providing gold standard recommendations for clinical direction and policy in cancer management for 25 years with a proven track record for improving outcomes while reducing costs. NCCN Guidelines are available free-of-charge for non-commercial use at NCCN.org or via the Virtual Library of NCCN Guidelines App.

The organization began providing recommendations for managing childhood cancers with the NCCN Guidelines for Pediatric Acute Lymphoblastic Leukemia (ALL), which launched in May 2019. Since then, those guidelines have been translated into multiple languages, and harmonized for lower-resource settings in sub-Saharan Africa—as part of the group Allied Against Cancer working in collaboration with the African Cancer Coalition (ACC), American Cancer Society (ACS), the Clinton Health Access Initiative (CHAI), and IBM. They have also been re-written in non-medical terms as NCCN Guidelines for Patients: Pediatric ALL in order to empower parents and guardians as well as patients.

NCCN has subsequently published NCCN Guidelines for Pediatric Aggressive Mature B-Cell Lymphomas. Additional new guidelines for children with Wilms tumors and central nervous system cancers are coming soon.

"Our mission to improve and facilitate quality, effective, efficient, and accessible cancer care so patients can live better lives is never more pressing than it is with young people who have many years ahead of them," said Robert W. Carlson, MD, Chief Executive Officer, NCCN.

On September 28, 2020 Avidity Biosciences, Inc. (Nasdaq: RNA), a biopharmaceutical company pioneering a new class of oligonucleotide-based therapies called Antibody Oligonucleotide Conjugates (AOCs), reported that Sarah Boyce, President and Chief Executive Officer, Arthur Levin, Ph.D., Chief Scientific Officer, and Mike MacLean, Chief Financial Officer, will participate in a fireside chat at the Chardan 4th Annual Genetic Medicines Conference 2020 on Monday, October 5th, 2020 at 12:45 pm PDT (Press release, Avidity Biosciences, SEP 28, 2020, View Source [SID1234567696]). In addition, Dr. Levin will participate in a featured panel entitled "Small RNA Therapies: Upcoming Advancements in Delivery and Stabilization Chemistries" on Tuesday, October 6th, 2020 at 12:00 pm PDT. The conference is being held in a virtual format.

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A live webcast of the virtual fireside chat will be available on the Company’s website at www.aviditybiosciences.com in the Investor Resources section. A replay of the fireside chat will be archived on the site for 90 days.

On September 28, 2020 -Legend Biotech Corporation (NASDAQ: LEGN) (Legend Biotech), a global clinical-stage biopharmaceutical company engaged in the discovery and development of novel cell therapies for oncology and other indications, reported that it will participate in the Jefferies Virtual Cell Therapy Summit on Tuesday, October 6th (Press release, Legend Biotech, SEP 28, 2020, View Source [SID1234567695]). Ying Huang, interim-Chief Executive Officer and Chief Financial Officer, will represent the Company in a session scheduled at 11:20 a.m. (Eastern Time).

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This webcast will be available to investors and other interested parties by accessing the Legend Biotech website at View Source

On September 28, 2020 Physicians’ Education Resource LLC (PER), a leading resource for continuing medical education, proudly reported it will present the International Society of Gastrointestinal Oncology (ISGIO) 17th Annual 2020 Gastrointestinal Oncology Conference, as a two-day continuing medical education (CME)-certified virtual, interactive meeting Oct. 2-3 (Press release, Physicians’ Education Resource, SEP 28, 2020, View Source [SID1234567694]).

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This year’s conference will be chaired by renowned expert Tanios S. Bekaii-Saab, M.D., professor, Mayo Clinic College of Medicine and Science, program leader, gastrointestinal cancer, Mayo Clinic Cancer Center and medical director, cancer clinical research office, Mayo Clinic.

"The ISGIO meeting has a long, rich history of providing quality CME-certified gastrointestinal (GI) cancer education to clinicians featuring some of the best minds in the field," said Phil Talamo, president of PER. "We look forward to utilizing our virtual interactive platforms, as well as expert speakers and resources, to deliver a highly engaging state-of-the-art two-day conference covering the hottest topics in GI cancer for 2020."

The 2020 Gastrointestinal Oncology Conference will provide the latest advances in the broad field of GI cancer research, as well as critical issues relevant to the care of persons with GI cancer. World-renowned thought leaders from different disciplines will educate clinicians using a combination of case-based learning, debates, panel discussions and didactic segments. Throughout the sessions, attendees will have the opportunity to interact with the faculty and ask questions via PER’s custom interactive platform.

Accredited by the Accreditation Council for Continuing Medical Education, this live activity will provide participants with the opportunity to earn 12.0AMA PRA Category 1 Credits.

On September 28, 2020 Diaceutics PLC, (AIM: DXRX), reported three new partnerships on its DXRX platform, as it continues with its mission to get every patient the treatment they deserve (Press release, Diaceutics, SEP 28, 2020, View Source [SID1234567693]). The company has signed agreements with external quality assessment (EQA) organizations Canadian Pathology Quality Assurance – Assurance Qualité Canadienne en Pathologie (CPQA-AQCP), European Molecular Genetics Quality Network (EMQN CIC) and Nordic Immunohistochemical Quality Control (NordiQC). The partnerships will help to establish best-in-class global laboratory standards for diagnostic testing through in-lab quality assurance and will provide the transparency which pharmaceutical companies need to reach more patients with their precision medicines.

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"Establishing partners in quality within the industry is important for CPQA-AQCP and we are excited with this opportunity to evolve our relationship with Diaceutics and participate in the DXRX network. "

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By partnering with CPQA-AQCP, EMQN CIC and NordiQC on DXRX – the world’s first diagnostic network for precision medicine – Diaceutics will support the implementation of accurate and high-quality testing across its 2500+ laboratory relationships.

These collaborations facilitate a critical piece of the end-to-end solution which DXRX enables for the development and commercialization of precision medicine diagnostics. They are also part of multiple partnerships which Diaceutics is building with industry providers across the globe to help achieve their mission of getting every patient the treatment they deserve.

Currently focused on the Canadian market, CPQA-AQCP is dedicated to monitoring and improving the proficiency of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) testing. DXRX is a global platform which will enable CPQA-AQCP to expand its services further worldwide. The organization is currently collaborating with Diaceutics on a project sponsoring the HER2 biomarker modules for gastric cancer. Using IHC and FISH, they are assessing the landscape and efficiency of HER2 gastric cancer testing, which has now been on the market for more than 10 years.

UK-based EMQN CIC provides molecular genetics, molecular pathology, and technique-specific EQA schemes for the global molecular testing market. It is currently collaborating with Diaceutics on a pilot study involving mutations in the EGFR, PIK3CA, KRAS, HRAS, NRAS, KIT, TP53 and BRAF genes, which will help laboratories using high throughput technologies – such as NGS – to accurately validate assay sensitivity and specificity. Data will be generated for a white paper to demonstrate a real-world review on NGS usage for clinical purposes: where we are today and the market readiness for additional biomarkers.

NordiQC is a global and scientific proficiency program for diagnostic Immunohistochemistry with more than 500 participants. NordiQC provides a broad range of relevant modules for immunohistochemical proficiency testing within diagnostic pathology and with special attention to predictive biomarkers. By joining the DXRX network, NordiQC strengthens its mission to bridge all stakeholders in diagnostic precision testing to optimize and standardize this field.

The addition of CPQA-AQCP, EMQN CIC and NordiQC on DXRX complements recent partnerships announced with HistoCyte Laboratories and Targos Molecular Pathology, which provide control slide materials and training for laboratories respectively.

John Garratt, Director, CPQA-AQCP, said: "Establishing partners in quality within the industry is important for CPQA-AQCP and we are excited with this opportunity to evolve our relationship with Diaceutics and participate in the DXRX network.

"Personalized medicine requires precision diagnostics to ensure the therapies are targeted accurately, thus providing optimum outcomes for patients. There is a greater demand on labs to provide prognostic biomarker testing of more esoteric targets and we, in EQA organizations, need to provide support for establishing the tests and for maintaining quality of the tests so that patients and their oncologists are confident that the most effective therapy is being used.

"Working with Diaceutics and its established partners is a great opportunity for CPQA-AQCP to assure accurate and sustainable pharma-diagnostic testing."

Simon Patton, Managing Director, EMQN CIC, said: "EMQN CIC and Diaceutics have a shared vision on improving the quality and accuracy of testing to ensure all patients get access, where possible, to the most effective treatments. We are delighted to be offering our ISO 17043 accredited Oncogene panel testing EQA scheme through the DXRX platform to support these goals."

Søren Nielsen, Director of NordiQC, said: "It’s with great expectations and excitement we enter the cooperation with Diaceutics. The partnership is driven by mutual interest and goal to raise and secure the global level of immunohistochemical precision testing and only by broad collaboration between laboratories, pharma, industry, regulatory bodies and EQA programs this can be accomplished."

Karina Hjort, Senior Director of Innovation, Diaceutics, said: "The precision medicine market is growing rapidly. Approximately 1,000 precision medicine drugs are currently in development and our research shows that by next year, the FDA will be approving more personalized oncology drugs than one-size-fits-all treatments. As they shift towards a personalized approach to treating patients, pharmaceutical companies must ensure that they are choosing the correct solutions and services to fulfil the promise of their precision medicines.

"We are delighted to have CPQA, EMQN CIC and NordiQC join the DXRX network to enable a critical piece of an end-to-end development and commercialization solution designed to get every patient the treatment they deserve."