Polaris announces to enroll the first patient of Phase IB Clinical Trial in GBM

On September 17, 2020 Polaris Group reported that the first patient has been dosed in a phase 1B trial of ADI‑PEG 20 in combination with Radiotherapy and Temozolomide for the treatment of Newly Diagnosed Glioblastoma Multiforme (GBM) (Press release, Polaris Pharmaceuticals, SEP 17, 2020, View Source [SID1234568214]). The Lead Investigator is Dr. Wei from Linkou Chang Gung Memorial Hospital. There will be 26 patients enrolled in this phase 1B trial.

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Entry into a Material Definitive Agreement

On September 17, 2020, Checkpoint Therapeutics, Inc., a Delaware corporation (the "Company"), reported that it entered into an underwriting agreement (the "Underwriting Agreement") with H.C. Wainwright & Co., LLC (the "Underwriter") (Filing, Checkpoint Therapeutics, SEP 17, 2020, View Source [SID1234565431]). Pursuant to the Underwriting Agreement, the Company agreed to sell to the Underwriter, and the Underwriter agreed to purchase for resale to the public, in a firm commitment underwritten public offering, 7,142,857 shares (the "Firm Shares") of the Company’s common stock, $0.0001 par value per share (the "Common Stock"), at a price to the public of $2.80 per share, less underwriting discounts and commissions. In addition, pursuant to the Underwriting Agreement, the Company has granted the Underwriter an option, exercisable for 30 days from the closing date of this offering, to purchase up to an additional 1,071,428 shares of Common Stock (the "Additional Shares" and, together with the Shares, the "Offered Shares") at the same offering price to the public, less underwriting discounts and commissions. On September 20, 2020, the Underwriter partially exercised its option purchase 178,572 Additional Shares. The offering of the Offered Shares was registered pursuant to a Registration Statement (No. 333-221493) on Form S-3, which was filed by the Company with the Securities and Exchange Commission on November 9, 2017 and declared effective on December 1, 2017, including a prospectus contained therein, as supplemented by a prospectus supplement, dated September 17, 2020, relating to this offering (the "Registration Statement"). A copy of the Underwriting Agreement is attached hereto as Exhibit 1.1 and is incorporated by reference herein.

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H.C. Wainwright & Co., LLC is acting as sole book-running manager for the offering.

The Company expects to receive net proceeds from the sale of the Offered Shares, after deducting underwriting discounts and commissions and other estimated offering expenses payable by the Company, of approximately $19.0 million, which includes proceeds from the additional shares of Common Stock to be sold pursuant to Underwriter’s partial exercise of its option to purchase additional shares. The offering, including the Additional Shares to be issued and sold pursuant to the partial exercise of the Underwriter’s option to purchase additional shares, is expected to close on September 22, 2020, subject to satisfaction of customary closing conditions.

The Underwriting Agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company and the Underwriter, including for liabilities under the Securities Act of 1933, as amended, other obligations of the parties and termination provisions.

Alston & Bird LLP, counsel to the Company, delivered an opinion as to the validity of the Offered Shares, a copy of which is attached hereto as Exhibit 5.1 and is incorporated by reference herein.

This Current Report on Form 8-K is being filed to incorporate the Underwriting Agreement and opinion by reference into such Registration Statement. The foregoing summary description of the offering and the documentation related thereto, including without limitation, the Underwriting Agreement, does not purport to be complete and is qualified in its entirety by reference to such exhibits.

The Underwriting Agreement has been included to provide investors and security holders with information regarding its terms. It is not intended to provide any other factual information about the Company. The representations, warranties and covenants contained in the Underwriting Agreement were made only for purposes of such agreement and as of specific dates, were solely for the benefit of the parties to such agreement, and may be subject to limitations agreed upon by the contracting parties, including being qualified by confidential disclosures exchanged between the parties in connection with the execution of the Underwriting Agreement. The representations and warranties may have been made for the purposes of allocating contractual risk between the parties to the agreement instead of establishing these matters as facts and may be subject to standards of materiality applicable to the contracting parties that differ from those applicable to investors. Investors are not third-party beneficiaries under the Underwriting Agreement and should not rely on the representations, warranties and covenants or any descriptions thereof as characterizations of the actual state of facts or condition of the Company or any of its subsidiaries or affiliates. Moreover, information concerning the subject matter of the representations and warranties may change after the date of the Underwriting Agreement, and this subsequent information may or may not be fully reflected in the Company’s public disclosures.

Selvita to present at the 20th Annual Biotech in Europe Forum For Global Partnering & Investment

On September 17, 2020 Selvita, one of the largest preclinical contract research organizations in Europe, reported that it will present at the 20th Annual Biotech in Europe Forum For Global Partnering & Investment. Instead of hosting an in-person format, the conference will be delivered as a fully digital event that will take place on the 21-24 September (Press release, Selvita, SEP 17, 2020, View Source;utm_medium=rss&utm_campaign=selvita-to-present-at-the-20th-annual-biotech-in-europe-forum-for-global-partnering-investment [SID1234565420]). The main program is being spread throughout four days and will feature high-level speeches and panel discussions. This event draws together public companies with leading investors, analysts, money managers, and pharma licensing executives.

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Edyta Jaworska, Member of the Management Board, Integrated Drug Discovery, is scheduled to present during the panel: Exciting Opportunities in Krakow, Poland – Life Science is Growing Here. The meeting will take place on the 23rd of September at around 4:00 PM CET and will last approximately 30 minutes. The virtual panel will include discussion, a brief presentation by each speaker as well as the Q&A session from the audience.

Adamis Pharmaceuticals Announces Proposed Public Offering of Common Stock

On September 17, 2020 Adamis Pharmaceuticals Corporation (Nasdaq: ADMP), a specialty biopharmaceutical company focused on developing and commercializing products in various therapeutic areas, including allergy, opioid overdose, respiratory and inflammatory disease, reported that it intends to offer to sell shares of its common stock in an underwritten public offering (Press release, Adamis Pharmaceuticals, SEP 17, 2020, View Source [SID1234565353]). The company expects to grant the underwriters of the offering a 30-day option to purchase up to an additional 15% of the number of shares of common stock offered in the public offering. The proposed offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Raymond James & Associates, Inc. will act as the sole book-running manager for the proposed offering.

The company intends to use the net proceeds from this offering for general corporate purposes, which may include, without limitation, expenditures relating to research, development and clinical trials relating to its products and product candidates, capital expenditures, manufacturing, hiring additional personnel, acquisitions of new technologies or products, the payment, repayment, refinancing, redemption or repurchase of existing or future indebtedness, obligations or capital stock, and working capital.

The securities described above will be offered by the company pursuant to a "shelf" registration statement on Form S-3 (File No. 333-226100) previously filed with and declared effective by the Securities and Exchange Commission (SEC) on July 18, 2018. A preliminary prospectus supplement and an accompanying prospectus relating to the offering will be filed with the SEC. Electronic copies of the preliminary prospectus supplement and the accompanying prospectus relating to the offering may be obtained, when available, from Raymond James & Associates, Inc., Attention: Equity Syndicate, 880 Carillon Parkway, St. Petersburg, Florida 33716, by telephone at (800) 248-8863, by e-mail at [email protected], or by accessing the SEC’s website at www.sec.gov.

This press release does not constitute an offer to sell or a solicitation of an offer to buy any securities described herein, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Zai Lab Conducting $845 Million IPO in Hong Kong

On September 17, 2020 Zai Lab of Shanghaireported that it is conducting a Hong Kong IPO that is expected to raise $845 million, based on the price of the company’s US-listed shares. On the NASDAQ Exchange, Zai has a market capitalization of $6.2 billion (Press release, Zai Laboratory, SEP 17, 2020, View Source [SID1234565349]). The company is developing a large portfolio of in-licensed cancer and infectious disease candidates. Its PARP inhibitor is approved for China use in ovarian cancer and a medical device, Tumor Treating Fields, is approved in China for glioblastoma.

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