On September 10, 2020 Akari Therapeutics, Plc (Nasdaq: AKTX), a late-stage biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory diseases where complement (C5) and/or leukotriene (LTB4) systems are implicated, reported that Clive Richardson, Chief Executive Officer, will participate and host investor meetings during the following upcoming virtual investor conferences (Press release, Akari Therapeutics, SEP 10, 2020, View Source [SID1234564952]):

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Event: H.C. Wainwright 22nd Annual Global Investment Conference
Date: Tuesday, September 15, 2020
Presentation: 1:30 p.m. ET
Event: Oppenheimer Fall Healthcare Life Sciences & MedTech Summit
Date: Wednesday, September 23, 2020
Presentation: 10:50 a.m. ET
Investors interested in arranging a virtual meeting with the Company’s management during either conference should contact the respective conference coordinator.

A live webcast and subsequent archived recording of each presentation will be available by visiting ‘Events’ in the Investor Relations section on the Company’s website at www.akaritx.com.

On September 10, 2020 Eli Lilly and Company (NYSE: LLY) reported that it will conduct a webcast on Monday, September 21, 2020 to discuss the company’s presentations at the 2020 European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Congress (Press release, Eli Lilly, SEP 10, 2020, View Source [SID1234564951]). The webcast will begin at 3:00 p.m. Eastern Daylight Time.

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Investors, media and the general public can access a live webcast of the conference call through a link that will be posted on Lilly’s website at View Source A replay will also be available on the website following the conference call.

On September 10, 2020 Bio-Path Holdings, Inc., (NASDAQ: BPTH), a biotechnology company leveraging its proprietary DNAbilize liposomal delivery and antisense technology to develop a portfolio of targeted nucleic acid cancer drugs, reported that Peter H. Nielsen, Chief Executive Officer, will present a corporate overview at the upcoming virtual H.C. Wainwright 22nd Annual Global Investment Conference on Wednesday, September 16, 2020 at 11:30 a.m. ET (Press release, Bio-Path Holdings, SEP 10, 2020, View Source [SID1234564950]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live webcast of the presentation can be accessed under "Events" in the Media section of the Company’s website at www.biopathholdings.com.

On September 10, 2020 Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported the first patient has been dosed in the Phase I dose escalation portion of a company-sponsored Phase I/II trial of BT8009, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4 (Press release, Bicycle Therapeutics, SEP 10, 2020, View Source [SID1234564948]). BT8009 is a second-generation BTC, which uses a valine-citrulline cleavable linker and a cytotoxin MMAE payload. It targets Nectin-4, which is a well-validated tumor antigen. Overexpression of Nectin-4 has been observed in several common tumor types and is associated with poor disease prognosis. The Phase I/II trial of BT8009 will be conducted in patients with advanced solid tumors associated with Nectin-4 expression.

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"BT8009 is one of a new class of tumor-targeting agents that we believe represent the next generation of treatments for solid tumors. With a molecular weight 50-100 times smaller than that of a typical antibody drug conjugate, or ADC, and the anticipated ability to fully penetrate tumors with precision, we believe Bicycles may have significant advantages over antibody-based approaches to tumor antigen targeting, a hypothesis supported by results from our preclinical studies," said Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. "In preclinical head-to-head comparisons with an ADC targeting Nectin-4, BT8009 demonstrated superior anti-tumor activity, including complete regressions of very large and small tumors across multiple xenograft models. Given BT8009’s potential utility, we plan to pursue a clinical development path that could enable us to bring this novel therapy to patients efficiently."

The Phase I/II multi-center, open-label trial will evaluate BT8009 administered once weekly. Enrollment is ongoing in the Phase I dose escalation of BT8009 given as a monotherapy, and the Company plans to evaluate BT8009 dosed in combination with an immune checkpoint inhibitor in future Phase I dose escalation cohorts. The Phase I portion of the trial is primarily designed to assess the safety and tolerability of BT8009, and to determine a recommended Phase II dose (RP2D). Following selection of an RP2D, Bicycle expects to initiate a Phase II dose expansion portion with the primary objective of evaluating the clinical activity of BT8009 in patients with Nectin-4-positive tumors.

On September 10, 2020 Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, reported that James Dentzer, President and Chief Executive Officer of Curis, will provide a company overview at two upcoming investor conferences (Press release, Curis, SEP 10, 2020, View Source [SID1234564947]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Cantor Fitzgerald Virtual Global Healthcare Conference: Fireside Chat – Tuesday, September 15, 2020 at 9:20 am ET.
H.C. Wainwright & Co. 22nd Annual Global Investment Conference: Tuesday, September 15, 2020 at 4:30 pm ET.
A live webcast of each presentation will be available under "Events & Presentations" in the Investors section of the Company’s website at www.curis.com. A replay of the webcast will be available on the Curis website for 90 days following the event.