On April 16, 2026 STORM Therapeutics Ltd. (STORM), the clinical stage company targeting RNA modifications to reprogram cells and develop novel cancer therapies, reported a successful $56 million Series C financing.

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The proceeds will support the advancement of STC-15, a first‑in‑class, oral small-molecule inhibitor of METTL3, including funding the Company’s Phase 2 monotherapy study in selected sarcoma indications, in which the first patient has now been successfully dosed. Sarcoma is a form of cancer that arises in bone or soft tissues, including muscle, fat, cartilage, blood vessels, and other connective or supportive tissue. This study is designed to support a potential accelerated regulatory approval pathway for STC-15 and to establish a foundation for subsequent clinical development across additional oncology indications.

STC-15 inhibits METTL3, an RNA-modifying enzyme involved in the regulation of cancer stem cell differentiation, a critical process in the development of sarcomas and other malignancies. In a Phase 1 monotherapy study, STC-15 demonstrated durable tumor regression across multiple sarcoma subtypes, underscoring its potential to target and reprogram progenitor cells that transform into cancer cells. These results will be presented at an upcoming medical conference in 2026.

Jerry McMahon, Chief Executive Officer of STORM Therapeutics, said: "Advancing our first‑in‑class METTL3 inhibitor, STC-15, into Phase 2 clinical development marks a pivotal breakthrough in tackling cancers characterized by aberrant cell differentiation. This milestone highlights our scientific innovation and the potential to create new therapeutic options for patients with substantial unmet needs. We are grateful for the steadfast support from our investors and are encouraged by the robust durability and activity demonstrated with STC-15 in Phase 1 studies. As we begin our Phase 2 trial, our focus remains on addressing critical unmet needs in sarcoma for the benefit of patients."

Jonathan Trent, MD of the University of Miami, Sylvester Comprehensive Cancer Center, commented: "The launch of the Phase 2 trial for STC-15 represents a significant advancement in the treatment landscape for sarcoma and other tumors driven by METTL3. STC-15’s novel mechanism of action targets sarcomas at their vulnerability, reprogramming malignant cells toward cell cycle arrest and apoptosis. We are hopeful that this research will yield meaningful insights and, ultimately, new therapeutic avenues for patients with pressing unmet needs."

STORM’s sarcoma program builds on previous clinical and translational research in epitranscriptomic regulation, emphasizing the importance of RNA-modifying enzymes in the maintenance of stem cell‑derived tumors and their potential application in broader settings. METTL3 methylates mRNA, influencing the differentiation processes of connective tissues and other cell types. Sarcomas arise from transformed mesenchymal stem cells as they progress into malignant connective tissue cells, accounting for 1% of adult cancers and 15% of pediatric cancers. Due to the frequent absence of driver mutations or immunogenic features amenable to standard treatments, sarcomas depend on METTL3-driven methylation for growth and survival. The Phase 2 trial will assess the anti-tumor effects of inhibiting mRNA methylation in sarcomas.

The financing was funded by existing investors, M Ventures, Pfizer Ventures, Taiho Ventures LLC, IP Group plc, the UTokyo Innovation Platform Co., Ltd. (UTokyo IPC), and Fast Track Initiative (FTI).

(Press release, STORM Therapeutics, APR 16, 2026, View Source [SID1234664461])

On April 16, 2026 TME Pharma N.V. (Euronext Growth Paris: ALTME), a clinical-stage biotechnology company specializing in the development of novel therapies for braincancer and eye diseases, reported a Nature Communications article on the results from the Phase 1/2 expansion Arm A cohort of the GLORIA trial testing NOX-A12 + radiotherapy + anti-VEGF "triple therapy" in glioblastoma patients.

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The article in the scientific peer-reviewed high-impact journal, Nature Communications, describes results of the expansion cohort Arm A in TME Pharma’s Phase 1/2 GLORIA trial. In this arm, chemotherapy-resistant (MGMT unmethylated) glioblastoma patients with residual tumor after surgery received NOX-A12 + radiotherapy + anti-VEGF (bevacizumab) "Triple Therapy". The authors noted that overall survival (OS) of patients receiving NOX-A12 Triple Therapy significantly outperformed two different cohorts of similar patients external to the trial who received standard of care treatment, and further noted that due to the conservative trial design, the study "likely underestimates survival compared with most contemporary trials."

As already disclosed in the March 5, 2024 press release, the GLORIA trial has been amended to allow inclusion of 100 additional patients in a randomized, controlled Phase 2 part of the trial composed of 5 additional arms (Expansion Group Arms D through H) to assess three different doses of NOX-A12 in the Triple Therapy, one dose of NOX-A12 + radiotherapy and standard of care. It is planned to initiate this Phase 2 part of the trial once appropriate partnerships are in place.

The findings described in the publication demonstrate the potential and value of TME Pharma’s NOX-A12 asset. TME Pharma remains confident in its strategy to search for a strategic partner to outlicense NOX-A12with the goal of bringing NOX-A12 to market authorization. As communicated on January 5, 2026, TME Pharma continues its active discussions with potential partners for the NOX-A12 program.

As indicated in its press release of March 9, 2026, TME Pharma’s financial runway now extends to Q2-2027, providing the company with the flexibility to identify the optimal partnership for NOX-A12.

Diede van den Ouden, CEO of TME Pharma, said: "We are encouraged by the publication in Nature Communications, which underscore the scientific validity of our approach. We remain fully committed to bringing NOX-A12 to success and believe that a strategic partnership is the optimal path forward. With our extended cash runway, we are well-positioned to continue our negotiations with potential partners."

(Press release, TME Pharma, APR 16, 2026, View Source [SID1234664460])

On April 16, 2026 Radiopharm Theranostics (ASX:RAD, "Radiopharm" or the "Company"), a clinical-stage biopharmaceutical company focused on developing innovative oncology radiopharmaceuticals for areas of high unmet medical needs, reported that the final patient has been dosed in the U.S. Phase 2b imaging trial (NCT06777433) evaluating RAD 101 in individuals with confirmed recurrent brain metastases from solid tumors of different origins.

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"Dosing the final patient in our most advanced diagnostic program represents an important milestone for Radiopharm and underscores the continued momentum of our radiopharmaceutical pipeline," said Riccardo Canevari, CEO and Managing Director of Radiopharm Theranostics. "The interim results we have seen to date, demonstrating a high level of concordance with MRI, reinforce our confidence in RAD 101’s potential to address a critical unmet need in the accurate detection of recurrent brain metastases. As we look ahead to the full data readout in June, we are focused on advancing this important program into U.S. pivotal trial and initiating constructive dialogue with the FDA to define the optimal regulatory pathway. We believe RAD 101 has the potential to meaningfully improve clinical decision-making for patients and physicians navigating this challenging disease."

"I would like to take the opportunity to thank all the patients, families, and caregivers for their trust in our clinical trial. The investigators and the Clinical Center did an amazing job in the recruitment process, and our congratulations go to BAMF HEALTH for leading the table of the top recruiters," added Mr. Canevari.

RAD 101 is the Company’s novel imaging small molecule that targets fatty acid synthase (FASN), a multi-enzyme protein that catalyses fatty acid synthesis and is overexpressed in many solid tumors, including cerebral metastasis. Targeting FASN activity may allow for the more accurate detection of cancer cells, representing a clinically relevant method for the imaging of brain metastases.

The U.S. multicenter, open-label, single arm Phase 2b clinical trial is evaluating the diagnostic performance of 18F-RAD101 in 30 individuals with confirmed recurrent brain metastases from solid tumors of different origins. The primary objective of the study is concordance between 18F-RAD101 positive lesions and those seen in conventional imaging (MRI with gadolinium) in participants with suspected recurrent brain metastases. RAD 101 received U.S. Food and Drug Administration (FDA) Fast Track Designation to distinguish between recurrent disease and treatment effect of brain metastases originating from solid tumors of different origin, including leptomeningeal disease.

In the U.S. alone, there are more than 300,000 patients diagnosed annually with cerebral metastases. The incidence of Intracranial Metastatic Disease (IMD) continues to increase, in part, due to improvements in systemic therapy resulting in a more durable control of the primary tumor. Contrast-enhanced Magnetic Resonance Imaging (CE-MRI) is the preferred method for imaging IMD, but has limitations, particularly in follow-up surveillance scans to optimise patient care.

(Press release, Radiopharm Theranostics, APR 16, 2026, View Source [SID1234664459])

On April 16, 2026 INmune Bio Inc. (NASDAQ: INMB) (the "Company"), a clinical-stage biotechnology company focused on developing therapies that harness the patient’s innate immune system, reported new preclinical data for INB03 (XPro1595 for oncology). The data will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026 in San Diego on April 17-22.

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The poster, titled, "Soluble TNF blockade overcomes tyrosine kinase inhibitors resistance in HER2-positive breast cancer," details how INB03 ("XPro"), a first-in-class dominant-negative soluble TNF (sTNF) inhibitor, significantly enhances the anti-tumor activity of the tyrosine kinase inhibitors (TKIs) lapatinib and tucatinib while reducing metastatic spread to the brain, lungs, and liver in HER2-positive breast cancer models. It was authored by collaborators from the Instituto de Biología y Medicina Experimental (IBYME-CONICET) in Buenos Aires, Argentina.

Key Scientific Findings:

Overcoming Resistance in Vitro: The combination of INB03 (10 µg/mL) with either lapatinib (1 µM) or tucatinib (10 µM) produced statistically superior inhibition of cell proliferation and migration in both HER2+ JIMT-1 and brain-metastatic JIMT-1 Br3-luc cell lines compared to TKIs alone (p < 0.05 to p < 0.0001).
Enhanced Tumor Control In Vivo: In female nude mice bearing JIMT-1 or JIMT-1 Br3-luc tumors, INB03 + TKI combinations markedly slowed tumor growth compared to TKIs alone.
Reduction of Metastatic Spread: The addition of INB03 significantly reduced the incidence of metastases to brain, lung, and liver (quantified by ex-vivo IVIS luminescence imaging). Notably, it further enhanced tucatinib’s effect on lung metastases (p < 0.05 to p < 0.0001).
Mechanism of Action: These results support prior research showing that selective sTNF neutralization with INB03 down-regulates MUC4, a protein that shields the HER2 molecule and prevents therapies from binding effectively.
"These results build on our prior work showing that selective sTNF neutralization with INB03 down-regulates MUC4, restoring sensitivity to HER2-targeted therapies," said Roxana Schillaci, Ph.D., lead investigator. "The ability of INB03 to overcome TKI resistance and limit metastatic dissemination, including to the brain, highlights its potential to address key unmet needs in advanced HER2-positive breast cancer."

David Moss, CEO of INmune Bio, added, "INB03 continues to demonstrate broad therapeutic potential across solid tumors by targeting the soluble TNF pathway. These AACR (Free AACR Whitepaper) data reinforce our confidence in advancing INB03 combinations in the clinic for patients who have developed resistance to standard TKIs or who are at high risk for brain metastases."

The poster will be available for viewing during the AACR (Free AACR Whitepaper) 2026 meeting on April 21st.

About XPro (INB03)

XPro is a next-generation inhibitor of tumor necrosis factor (TNF) that is currently in clinical trial and acts differently than currently available TNF inhibitors in that it neutralizes soluble TNF (sTNF), without affecting trans-membrane TNF (tmTNF) or TNF receptors. XPro could have potential substantial beneficial effects in patients with neurologic disease by decreasing neuroinflammation. For more information about the importance of targeting neuroinflammation in the brain to improve cognitive function and restore neuronal communication visit this section of INmune Bio’s website.

(Press release, INmune Bio, APR 16, 2026, View Source [SID1234664458])

On April 16, 2026 Myriad Genetics, Inc. (NASDAQ: MYGN), a leader in molecular diagnostic testing and precision medicine, reported that it will share six abstracts, including two podium presentations, at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026.

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"AACR is one of the premier forums for oncology research, and we are excited to share the depth of work underway across our MRD and hereditary cancer programs, including two podium presentations demonstrating the exceptional performance of Precise MRD, Myriad’s tumor-informed, ultrasensitive MRD assay," said Dale Muzzey, PhD, Chief Scientific Officer, Myriad Genetics.

The company will share new results from the MONITOR-Breast study, a prospective, multi-center clinical trial evaluating the performance of Precise MRDTM in breast cancer across all phases of the treatment journey. The data will be shared in a podium presentation on Monday, April 20, 2026 by Dr. Julia Foldi, MD, PhD, University of Pittsburgh Medical Center Hillman Cancer Center. These results expand on the study’s early insights presented at the San Antonio Breast Cancer Symposium in December 2025, including results from a large cohort of patients receiving neoadjuvant therapy with frequent MRD assessment, providing the first high-temporal resolution characterization of ctDNA dynamics in all breast cancer subtypes during neoadjuvant treatment.

"Breast cancer treatment has evolved significantly, but clinicians still face real challenges in assessing how well a patient is responding to therapy in the neoadjuvant setting," said Dr. Foldi. "The data being presented at AACR (Free AACR Whitepaper) reveal distinct response patterns that are associated with pathological response and demonstrate that frequent, ultrasensitive MRD testing can provide personalized information about treatment effectiveness. MONITOR-Breast is generating important clinical evidence for Precise MRD in breast cancer that could help oncologists personalize treatment decisions for their patients."

Additionally, Dr. Ranjan Upadhyay from The University of Texas MD Anderson Cancer Center will present the results of a phase II clinical trial. Together, these results from clinical trials continue to build and expand the evidence supporting the performance of the Precise MRD test in breast cancer treatment and surveillance.

The following abstracts will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting on April 17-22, 2026, at the San Diego Convention Center in San Diego.

Myriad Genetics Presentations
Session CTMS04 – Focus on ctDNA
Early findings from MONITOR-Breast: ctDNA dynamics during neoadjuvant therapy using an ultrasensitive MRD assay
Podium; Abstract Presentation Number: CT171
Mon., April 20 – 2:50 – 3:00 pm, Hall H – Ground Level – Convention Center
Presenter: Julia Foldi, MD, PhD, University of Pittsburgh Medical Center

Session CTMS04 – Focus on ctDNA
A phase II trial of adjuvant PD-1 blockade with endocrine therapy in hormone receptor positive inflammatory breast cancer: Circulating biomarkers and molecular correlates of clinical outcomes
Podium; Abstract Presentation Number: CT172
Mon., April 20 – 3:05 – 3:15 pm PST, Hall H – Ground Level – Convention Center
Presenter: Ranjan Upadhyay, MD, PhD, The University of Texas MD Anderson Cancer Center

Liquid Biopsies: Circulating Nucleic Acids 2
Analytical validation of an ultra-high sensitivity tumor-informed MRD assay
Poster Board Number: 2598
Mon., April 20 – 9:00 am – 12:00 pm PST
Presenter: Ashley Acevedo, PhD, Myriad Genetics

Genetic Epidemiology 1: GxE, GWAS, Polygenic Risk Scores, and Post-GWAS
Independent validation of polygenic risk scores for overall and triple-negative breast cancer among high-risk African American women
Poster Board Number: 3587
Mon., April 20 – 2:00 – 5:00 pm PST
Presenter: Dezheng Huo, PhD, University of Chicago

Liquid Biopsies: Circulating Nucleic Acids 4
Fragmentomic analysis of cfDNA WGS at regulatory regions generates gene-level expression-like traits for subtype analysis in breast cancer
Poster Board Number: 5313
Tues, April 21 – 9:00 am – 12 pm PST
Presenter: James Davison, PhD, GeneCentric Therapeutics, Inc.

Phase I and Phase II Clinical Trials in Progress
A pragmatic study of the clinical utility of genomic classifiers in guiding prostate cancer treatment decisions: Impact of treatment selection, oncologic outcomes, and treatment-related adverse events (PROMPT-Bx)
Poster Board Number: 14; Abstract Presentation Number: CT280
Tues., April 21 – 2:00-5:00 pm PST
Presenter: Matthew Schiewer, PhD, Myriad Genetics

Conference Highlights
Myriad will welcome attendees to its booth (#3747) during exhibition hours. Myriad tests to be highlighted at the conference booth include:

Precise MRD (Molecular Residual Disease) Test is a tumor-informed assay that uses whole genome sequencing (WGS) to achieve ultra-sensitivity. This unique assay enables the custom selection of up to 1,000 targeted variants for deep analysis. It has impressive limits of detection and sensitivity.1 The test can be used to monitor circulating tumor DNA (ctDNA) levels throughout a patient’s clinical cancer care, starting immediately after diagnosis and continuing through treatment and surveillance.
MyRisk Hereditary Cancer Test with RiskScore combines genetics, clinical factors (Tyrer-Cuzick), and polygenic risk to uncover insights that gene testing alone may not provide, helping offer more information to support patient decisions in breast cancer risk assessment and management.
Prolaris Prostate Cancer Prognostic Test is a molecular diagnostic test that provides personalized information about the aggressiveness of a patient’s prostate cancer, helping to identify whether it is safe to forgo treatment, whether to pursue treatment, and how much treatment is needed for the best possible outcome. Prolaris is the only biomarker test to quantify the benefits of adding androgen ADT to RT.
The booth will feature Myriad’s Biopharma services which are utilized for working in conjunction with Biopharma partners to advance drug development programs from biomarker discovery through CTA, CDx development, worldwide regulatory approval and global commercialization, including:

MyChoice CDx is the only FDA-approved homologous recombination deficiency (HRD) test specifically mentioned in ASCO (Free ASCO Whitepaper) guidelines for selecting patients with ovarian cancer who may benefit from PARP inhibitors.1 By determining comprehensive HRD status, the MyChoice CDx Test helps expand access to targeted therapy in both early and late-line settings.
MSK-ACCESS is a comprehensive liquid biopsy test developed by Memorial Sloan Kettering Cancer Center (MSK). The test offers noninvasive cancer genomic profiling and disease monitoring using cell-free DNA (cfDNA) obtained from blood and other body fluids. The test is currently available for use in conjunction with Myriad’s Pharma partnerships for CTA development and CDx utilizing Myriad’s partnership with SOPHiA GENETICS.
MSK-IMPACT is a solid tumor test for comprehensive genomic profiling (CGP) which delivers high-resolution profiling of complex biomarkers from DNA and RNA in a single, end-to-end workflow. The test is currently available for use in conjunction with Pharma partnerships for CTA development and CDx utilizing Myriad’s partnership with SOPHiA GENETICS.
Myriad Genetics will also participate in the Exhibitor Spotlight Theater: "Advances in ctDNA Testing towards Biopharma Development & Clinical Dx" on Sun., April 19 from 3:30 – 4:30 pm in Theater B. The Spotlight Theater will highlight Myriad’s latest developments for Precise MRD, as well as the results of Myriad’s collaboration with GeneCentric Therapeutics and its ExpressCT liquid biopsy technology.

References:

Tew WP, Lacchetti C, Birrer MJ, et al. PARP inhibitors in the management of ovarian cancer: ASCO (Free ASCO Whitepaper) guideline. J Clin Oncol. 2020;38(30):3468-3493.
About the MONITOR-Breast Study
MONITOR-Breast is a prospective, multicenter observational study evaluating patients with Stage I-III breast cancer across all subtypes. The study systematically assessed ctDNA using Precise MRD, a tumor-informed whole-genome sequencing (WGS)-based assay, at frequent intervals during neoadjuvant therapy, with a median of 9 timepoints per patient. This design enabled a high-resolution, longitudinal analysis of ctDNA dynamics across the neoadjuvant treatment course.

(Press release, Myriad Genetics, APR 16, 2026, View Source [SID1234664457])