ChromaDex Corporation Reports Second Quarter 2020 Financial Results

On August 6, 2020 ChromaDex Corp. (NASDAQ:CDXC) reported second quarter 2020 financial results (Press release, ChromaDex, AUG 6, 2020, View Source [SID1234568251]).

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"We achieved record net sales of $15.3 million in the second quarter while maintaining our focus on the science, announcing our 200th research agreement and tenth published human trial on Niagen," says ChromaDex CEO Rob Fried. "Business adjustments at the onset of the pandemic and continued marketing efficiencies allowed us to reach a financial goal of positive Adjusted EBITDA excluding total legal expenses."

Results of operations for the three months ended June 30, 2020

For the three months ended June 30, 2020 ("Q2 2020"), ChromaDex reported net sales of $15.3 million, up 38% compared to $11.1 million in the second quarter of 2019 ("Q2 2019"). The increase in Q2 2020 revenues was driven by growth in sales of Tru Niagen and Niagen ingredient revenues.

Gross margin increased by 310 basis points to 59.4% in Q2 2020 compared to 56.3% in Q2 2019. The increase in gross margin was largely driven by the positive impact of increased Tru Niagen consumer product sales and product cost saving initiatives, including a benefit of approximately 110 basis points related to savings from prior year initiatives that were recognized in Q2 2020.

Operating expenses decreased by $0.7 million to $12.8 million in Q2 2020, compared to $13.4 million in Q2 2019. The decrease in operating expenses was driven by a decrease of $1.1 million in general and administrative expense, and a decrease of $0.1 million of research and development expense, partially offset by $0.7 million of higher selling and marketing expense. The decrease in general and administrative expense was driven by $1.1 million of lower legal expenses.

The net loss for Q2 2020 was ($3.7) million or ($0.06) per share compared to a net loss of ($7.8) million or ($0.14) per share for Q2 2019.

Adjusted EBITDA excluding total legal expense, a non-GAAP measure, was a profit of $0.5 million for Q2 2020, compared to a loss of ($2.1) million for Q2 2020, a $2.6 million improvement.

ChromaDex defines Adjusted EBITDA excluding total legal expense as net income or (loss) which is adjusted for interest, income tax, depreciation, amortization, non-cash stock compensation costs, severance and restructuring expense, bad debt expense related to Elysium Health and total legal expense.

For Q2 2020, the net cash used in operating activities was ($1.6) million versus ($9.0) million in Q2 2019.

2020 Outlook

Looking forward, the impact of COVID-19 on revenues is difficult to predict and the Company is managing expenses to mitigate the bottom-line impact. The Company does not expect any supply chain disruption at this time and, based on trends-to-date, expects continued revenue growth this year. Based on the Company’s current financial outlook, revenue growth will be driven by its U.S. ecommerce business, new international market launches with its partners and distributors, such as in the U.K. and Australia, new online platforms, including Persona Nutrition, a Nestlé Health Science company, and the Company’s new product, Tru Niagen Beauty. The Company expects continued gross margin improvement driven by a higher mix of Tru Niagen sales, product design changes implemented in late 2019, and additional supply chain cost savings initiatives in 2020. The Company expects lower selling, marketing and advertising as well as general and administrative expenses as a percentage of net sales driven by strong growth from returning customers and scale on our fixed overhead costs driven by organizational realignment initiatives, as well as new systems and processes.

Investor Conference Call

ChromaDex management will host an investor conference call to discuss the first quarter results and provide a general business update on Thursday, August 6, at 4:30pm ET.

Participants should call in at least 10 minutes prior to the call. The dial-in information is as follows:

Date: Thurs., August 6, 2020
Time: 4:30 p.m. Eastern time (1:30 p.m. Pacific time)
Toll-free dial-in number: (833) 979-2703

International dial-in number: (236) 714-2223
Conference ID: 1563949
Webcast link: ChromaDex Second Quarter 2020 Earnings Conference Call

The conference call will be broadcast live and available for replay here and via the investor relations section of the Company’s website at www.chromadex.com.

A replay of the conference call will be available after 7:30 p.m. ET.

Toll-free replay number: 800-585-8367
Replay ID: 1563949

The earnings press release, and its accompanying financial exhibits, will be available on the Investor Relations section of the Company website, www.chromadex.com.

ISA Pharmaceuticals to present at the Virtual 6th Solebury Trout Summer 2020 Private Company Showcase

On August 6, 2020 ISA reported that it will present at the 6th Solebury Trout Summer 2020 Private Company Showcase, hosted by Piper Sandler and White & Case. You are welcome to tune in (Press release, ISA Pharmaceuticals, AUG 6, 2020, View Source [SID1234565550]).

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Date: Monday, 10 August 2020

Time: 5:00pm CET / 11:00am EDT.

Webcast: View Source

You may access the stream 15 minutes in advance and a replay of the webcast will be available for 60 days.

ImmVira and Shanghai Pharma Announce Clinical Collaboration and License Agreement for Commercialization of Novel Intratumoral Oncolytic Virus Immunotherapies

On August 6, 2020 ImmVira Group Company and Shanghai Pharmaceuticals Holding Co., Ltd reported a clinical collaboration and exclusive license agreement for ImmVira’s MVR-T3011 intratumoral oncolytic virus program for the commercialization of novel immunotherapies to treat solid malignant tumors (Press release, Immvira, AUG 6, 2020, View Source [SID1234563687]).

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ImmVira’s MVR-T3011 oncolytic virus program has innovated with a genetically engineered oncolytic herpes simplex virus-1 (oHSV-1) to enhance the known oncolytic effects of oHSV-1. Through gene recombinant technologies, PD-1 antibody and interleukin-12 immune modulators are expressed within the virus. Oncolysis is achieved with additional immune response stimulation while keeping the boosted immune activity limited to the locality of MVR-T3011 to achieve a potentially favorable safety profile. The MVR-T3011 intratumoral program aims to target most solid malignant tumors with both remission rate improvement and safety improvement over immune modulator monotherapies. As part of the agreement, Shanghai Pharma will receive an exclusive license and gain access to ImmVira’s MVR-T3011 virus for clinical development, manufacturing and commercialization within certain fields of use in mainland China, Hong Kong, Macau and Taiwan (the Greater China region). ImmVira and Shanghai Pharma will collaborate on clinical trials in China with exclusive commercial rights for intratumoral therapies developed under the agreement assigned to Shanghai Pharma for the Greater China region. ImmVira retains full development and commercialization rights for regions outside of Greater China.

Under the terms of the agreement, ImmVira will receive from Shanghai Pharma an upfront payment and contingent milestone payments that would in the aggregate amount to RMB1.15 billion, as well as royalty payments of up to 12% of net revenues should Shanghai Pharma successfully commercialize a therapy from the collaboration.

"As we continue to lead in oncolytic virus research and development, we are delighted to collaborate with Shanghai Pharma on our first product pipeline," said Grace Zhou, chairman and chief executive officer of ImmVira. "This partnership represents an exceptional opportunity to leverage Shanghai Pharma’s leadership in immunotherapy research, clinical stage expertise, manufacture and countrywide distribution network. With a strong partner like Shanghai Pharma, we are more confident in the commercial success of MVR-T3011 and achieve our goal in engineering more effective yet safer remedies for cancer patients."

"ImmVira is a leader in providing best-in-class oncolytic virotherapy treatments for patients in need. We are pleased to collaborate with ImmVira and have MVR-T3011 intratumoral program join our market leading commercial pipeline. The MVR-T3011 design is a breakthrough novel approach to cancer treatment over monotherapies," said Zuo Min, Executive Director and President of Shanghai Pharma. "In-line with our dedication to providing innovative, safe and effective drugs against serious and chronic diseases, MVR-T3011 represents a sound scientific approach to cancer treatment. We are confident in its eventual commercial success not only as a first-in-class product but also a best-in-class product."

10-Q – Quarterly report [Sections 13 or 15(d)]

CTI BioPharma has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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WUXI VACCINES APPOINTS MR. JIAN DONG AS CHIEF EXECUTIVE OFFICER

On August 6, 2020 WuXi Vaccines, a global leading company with world-class vaccine contract development and manufacturing organization (CDMO) capabilities, reported the appointment of Mr. Jian Dong as Chief Executive Officer (CEO) (Press release, WuXi Biologics, AUG 6, 2020, View Source [SID1234563468]). WuXi Vaccines is a joint venture established between WuXi Biologics and Shanghai-based Hile Bio-Technology.

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"We are delighted to announce Jian’s new appointment. He is a highly regarded leader with over 30 years of bio-pharmaceutical experience, including vaccine production, process development, as well as the design, construction, qualification and operation management of cGMP manufacturing facilities," said Dr. Chris Chen, Chairman of WuXi Vaccines, "We are confident that Jian will lead the company to establish a global high-quality system with outstanding vaccine CDMO capabilities. With a vision to accelerate and transform vaccine development and production, WuXi Vaccines will make substantial contributions to expedite vaccine development and ensure a robust supply chain."

"I am excited for the opportunity to lead WuXi Vaccines. By leveraging our robust capacities and state-of-the-art technologies, the company will further increase its unique presence in the vaccine industry to enable global partners and benefit patients worldwide." Commented Mr. Jian Dong.

Mr. Jian Dong joined WuXi Biologics in 2014, and had been responsible for global biomanufacturing, global engineering, and the overall operations of Wuxi site since 2015. Under the excellent leadership of Mr. Jian Dong, Wuxi site became the first GMP biologics Drug Substance (DS) and Drug Product (DP) facilities in China certified by both the US FDA and EMA. Prior to WuXi Biologics, Mr. Jian Dong spent decades in various roles with increasing responsibilities at Eli Lilly & Co. in the US, Shanghai United Cell Biotechnology and Shenzhen Kangtai Biological Products Co., Ltd. With extensive experience in vaccine manufacturing and facility qualification, he had made significant contributions to the tech transfer and large scale commercial production of recombinant hepatitis B vaccine in China.

In February, WuXi Vaccines completed modular lab installation of its vaccine manufacturing facility in Ireland, which represents a great milestone since the announcement of 240 million USD investment last November. With smooth progress made in the site construction, this integrated vaccine manufacturing facility is expected to be operational in 2021.