On October 8, 2019 Propanc Biopharma, Inc., a Delaware corporation (the "Company"), reported that it has entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") whereby an investor (the "Investor") purchased from the Company, for a purchase price of $125,000 (the "Purchase Price") a Convertible Redeemable Promissory Note, in the principal amount of $131,000 (the "Note") (Filing, 8-K, Propanc, OCT 8, 2019, View Source [SID1234540948]). The Purchase Price was funded on October 2, 2019.

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The Securities Purchase Agreement contains such representations, warranties and covenants as are typical for a transaction of this nature.

Convertible Redeemable Promissory Note

The Note is due and payable on October 1, 2020 (the "Maturity Date") and entitles the holder to 8% interest per annum (the "Interest Rate"). The Note may be converted into shares of the Company’s common stock equal to 40% discount of the lowest closing bid price of the Common Stock, for the ten trading days immediately prior to the delivery of a notice of conversion; provided, however, such conversion shall not be effected to the extent that the Investor together with any of its affiliates would beneficially own in excess of 4.99%, which may be increased up to 9.99% upon 60 days’ prior written notice by the Investor to the Company. The Company may redeem the Note prior to April 2, 2020, as follows: (i) if the redemption occurs within the first 60 days then an amount equal to 115% of the face amount of the Note plus any accrued interest, (ii) if the redemption occurs after the 61st day but on or before the 120th day following the issuance of the Note, then an amount equal to 125% of the face amount of the Note along with any accrued interest, (iii) if the redemption occurs after the 121st day but on or before the 180th day following the issuance of the Note, then an amount equal to 135% of the face amount of the Note along with any accrued interest.

In the event of a default, without demand, presentment or notice, the Note shall become immediately due and payable.

The foregoing provides only brief descriptions of the material terms of the Securities Purchase Agreement and the Note, and does not purport to be a complete description of the rights and obligations of the parties thereunder, and such descriptions are qualified in their entirety by reference to the full text of the forms of Securities Purchase Agreement and the Note, respectively, filed as exhibits to this Current Report on Form 8-K, and are incorporated herein by reference.

On October 8, 2019 INmune Bio, Inc. (NASDAQ: INMB), an immunology company focused on developing treatments that harness the patient’s innate immune system to fight disease, reported that RJ Tesi, M.D., Co-Founder and CEO, will present at the 2nd Annual Advances in Immuno-Oncology USA Congress in San Diego taking place on Oct. 8 and Oct. 9 (Press release, INmune Bio, OCT 8, 2019, View Source [SID1234540947]). Dr. Tesi and CJ Barnum, Ph.D., Director of Neuroscience, will also present at the World Immunotherapy Congress taking place in Basel, Switzerland from Oct. 15 through 17.

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"The immuno-oncology field is rapidly growing, and emerging new therapies are at the center of attention," said Dr. Tesi. "With 30% of breast cancer patients being HER2+, trastuzumab has made significant strides in the treatment of breast cancer. Yet, many HER2+ breast cancer patients have shown resistance to the drug. In my presentation during the Advances in Immuno-Oncology USA Congress, I will address one of the reasons for the resistance – specifically the presence of the MUC4 biomarker – and how we may be able to use a soluble TNF inhibitor, such as our drug candidate INB03, to increase the efficacy of trastuzumab in those women who have shown resistance."

Advances in Immuno-Oncology USA Congress brings together global pharmaceutical organizations, leading biotech companies and presents a unique chance to connect scientists on the latest innovations in immuno-oncology therapy development, research and more.

"Our approach to treating patients with Alzheimer’s disease is focused on targeting the root of the disease, chronic inflammation and how we can leverage biomarkers," said Dr. Barnum. "It’s an honor to have the opportunity to present alongside some of the most prominent leaders in the immunotherapy community to approach the field from a non-oncology perspective."

The World Immunotherapy Congress is one of four conferences coordinated by the Festival of Biologics. The vision of the World Immunotherapy Congress is to bring together the full community and provide a single meeting point for where science meets business to make immunotherapy the cornerstone of the fight against cancer and other diseases.

Details on each speaking engagement can be found below:

Advances in Immuno-Oncology USA Congress:
Tuesday, October 8 at 5:20 p.m.
"Targeting Soluble TNF To Reverse Trastuzumab Resistance"
Dr. Tesi will address trastuzumab resistance in breast cancer patients due to the presence of MUC4, and the role of soluble TNF in MUC4 expression in HER2+ breast cancer. He will discuss how using INB03 as part of combination therapy may have positive effects in reversing trastuzumab resistance.

Wednesday, October 9 at 8:00 a.m.
"Alternative Therapeutic Strategies Beyond Checkpoint Inhibitors"
Serving as a moderator, Dr. Tesi will lead a table discussion of notable company spokespeople, covering the latest advances in immunotherapy.

World Immunotherapy Congress:
Tuesday, October 15 at 3:10 p.m.
"Targeting Protector Cells of the TME to Improve Efficacy of Immunotherapy"
Dr. Tesi will lead a discussion around "protector cells" of the TME and how they promote resistance to immunotherapy, and how eliminating MDSC and TAM will improve response to therapy. He will also discuss how INmune’s drug, INB03 targets sTNF as an effective strategy for eliminating MDSC and TAM.

The "Tumor microenvironment" session of the conference will be chaired by Dr. Tesi.

Wednesday, October 16 at 4:40 p.m.
"Approaching Alzheimer’s disease as an immunological disease: role of biomarkers"
Dr. Barnum will discuss how innate immune regulation causes chronic inflammation and development of Alzheimer’s disease, and how approaching AD as an immunological disease changes the clinical strategy, especially when developing biomarkers.

Dr. Barnum will also chair the "Immunotherapy for non-oncology" session of the conference.

On October 3, 2019, Heron Therapeutics, Inc. (the "Company") reported that it has entered into an underwriting agreement (the "Underwriting Agreement") with Jefferies LLC, Cowen and Company, LLC and Evercore Group L.L.C., as representatives of the several underwriters identified in Schedule A thereto (the "Underwriters"), pursuant to which the Company (i) agreed to issue and sell an aggregate of 8,571,429 shares of its common stock (the "Shares") to the Underwriters and (ii) granted the Underwriters an option for 30 days to purchase up to an additional 1,285,714 shares of its common stock that may be sold upon the exercise of such option by the Underwriters (the "Offering") (Filing, Heron Therapeutics, OCT 8, 2019, View Source [SID1234540946]). The Shares were sold at a public offering price of $17.50 per Share and, except with respect to the Shares sold to Tang Capital Partners, LP ("TCP"), were purchased by the Underwriters from us at a price of $16.45 per Share. TCP, an affiliate of Kevin Tang, the Chairman of the Board of Directors of the Company, agreed to purchase 285,714 of the Shares in the Offering at the public offering price. The Underwriters did not receive any underwriting discounts or commissions with respect to the sale of Shares to TCP.

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We estimate that the net proceeds we will receive from the Offering, excluding the proceeds from the additional 1,285,714 shares of common stock that may be purchased by the Underwriters following the exercise of their option, will be approximately $141.1 million, after deducting the Underwriters’ discounts and commissions and estimated offering expenses payable by us.

The Offering was made pursuant to the Company’s automatically effective registration statement on Form S-3 (Registration No. 333-219172), which was previously filed with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the "Securities Act").

The Offering closed on October 8, 2019. In the Underwriting Agreement, the Company agreed to indemnify the Underwriters against certain liabilities, including liabilities under the Securities Act, or to contribute to payments that the Underwriters may be required to make because of such liabilities. A copy of the Underwriting Agreement is attached as Exhibit 1.1 hereto and is incorporated herein by reference. The foregoing description of the Underwriting Agreement does not purport to be complete and is qualified in its entirety by reference to such exhibit.

On October 8, 2019 Cellectar Biosciences, Inc. (NASDAQ: CLRB), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, reported a poster presentation at the upcoming Cancer Research UK-AACR Joint Conference on Engineering and Physical Sciences in Oncology, being held from October 15 – 17, 2019 in London, United Kingdom (Press release, Cellectar Biosciences, OCT 8, 2019, View Source [SID1234540943]).

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Poster Details

Poster Title: Phospholipid lipid ether delivery vehicle shows specificity for a broad range of tumor cells and provides a novel and improved approach for targeted therapy.
Date: Tuesday, October 15, 2019, 9 a.m. – 5 p.m.
Location: Leonardo Royal Hotel Tower Bridge, London, UK

A copy of the presentation materials can be accessed on the Posters and Publications section of the Cellectar website once the presentation concludes.

On October 8, 2019 The Excelera Network was selected by Karyopharm Therapeutics, Inc., to be in the limited distribution network for XPOVIO (selinexor), which was approved as a treatment for patients with multiple myeloma by the U.S. Food and Drug Administration (FDA) (Press release, Karyopharm, OCT 8, 2019, View Source [SID1234540124]). The Excelera Network, which includes over 20 health systems, 500 hospitals and 100K physicians, received immediate access to the drug upon FDA approval in July.

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"We are pleased to be included in Karyopharm’s limited distribution network for XPOVIO," said Rebecca Rand, vice president of manufacturer relations at Excelera. "XPOVIO offers adults with multiple myeloma who have exhausted other options with a novel therapy option to treat their disease. We are committed to providing our health systems with rapid access to innovative therapies such as XPOVIO, as well as the necessary clinical knowledge to effectively deliver these therapies to complex patients in an integrated care model."

XPOVIO is a nuclear export inhibitor that has been approved for use in combination with the corticosteroid dexamethasone, for treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. Approved by the FDA on July 3, 2019, XPOVIO was granted both Fast Track and Orphan Drug designation and received accelerated approval, which enables the FDA to approve drugs for serious conditions and to fill an unmet medical need.

"We are delighted to be working with Excelera to help meet the growing demand for XPOVIO in the U.S.," said Kirk Schamp, vice president of market access at Karyopharm. "Excelera has proven capabilities enhancing patient access to novel medicines and we look forward to working together to serve the needs of physicians and their patients battling multiple myeloma."

Multiple myeloma is a cancer that forms in plasma cells. Abnormal plasma cells accumulate in the bone marrow, where they crowd out healthy blood cells and form tumors in many bones of the body. Multiple myeloma is the second most common cancer of the blood in the U.S., with more than 32,000 new cases each year and over 130,000 patients currently living with the disease.

To learn more about Excelera or becoming a member of the Excelera Network, contact us at View Source