ALX Oncology to Present ALX148 Clinical Biomarker Data at the 34th Annual Meeting of the Society for Immunotherapy of Cancer (SITC)

On October 2, 2019 ALX Oncology, a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, reported that it will be presenting clinical biomarker data from its ongoing ALX148 phase 1 clinical program at the SITC (Free SITC Whitepaper) 34th Annual Meeting, November 6-10, 2019 at the Gaylord National Hotel & Convention Center in National Harbor, Maryland (Press release, ALX Oncology, OCT 2, 2019, View Source [SID1234540025]).

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Poster Presentation Information
Title: Pharmacodynamic biomarker characterization of ALX148, a CD47 blocker, in combination with established anticancer antibodies in patients with advanced malignancy (Abstract P449)
Date: Friday, November 8, 2019
Time: 7:00 am – 8:00 pm

Torque Therapeutics Announces the Appointment of John Cox as Chief Executive Officer

On October 2, 2019 Torque Therapeutics, a clinical stage, product-platform company developing proprietary, first-in-class Deep Primed adoptive cell transfer therapeutics with uniquely broad potential to treat patients with a wide range of hematologic and solid malignancies, reported the appointment of John Cox as Chief Executive Officer (Press release, Torque Therapeutics, OCT 2, 2019, View Source [SID1234540024]).

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Douglas Cole, Lead Director of Torque and Managing Partner at Flagship Pioneering, said, "I am thrilled that John has taken on the role of CEO of Torque. His accomplishments delivering value to shareholders are among the most significant in the biotechnology industry. Over the course of his career, he has demonstrated his ability to advance and commercialize products, build teams, and guide and drive organizations. He is a true leader. I am excited to work with John as he leads development of Torque’s growing pipeline of clinical and preclinical proprietary products, continues to build on Torque’s robust Deep Primed T Cell platform, and expands the Torque capital base."

Mr. Cox was most recently Chief Executive Officer of Bioverativ. He led the Bioverativ spin-out from Biogen in 2016 and the sale of Bioverativ to Sanofi for $11.6B in 2018. He previously served in roles of increasing seniority at Biogen, ultimately as Executive Vice President of Pharmaceutical Operations and Technology overseeing global manufacturing facilities, supply chain operations, technical development, quality and engineering, and development and commercialization of Biogen’s biosimilars business.

"I am delighted to take leadership of Torque Therapeutics," Mr. Cox said. "After the sale of Bioverativ, I assessed many opportunities to run a company that could really change patients’ lives. I believe Torque represents one of the most compelling approaches to do that."

Cox went on, "Torque is poised to move the field of adoptive cell transfer from niche use in small groups of late-stage patients with particular hematologic malignancies to broad use across multiple groups of early- and late-stage patients with a broad range of range of hematologic and solid malignancies. Torque’s Deep Primed product-platform is the only approach that has been developed that combines the ability to address the inherent variability of each patient’s malignancy, safely harness the critical power of cytokines and other immune agonists, and cost-effectively manufacture therapeutic products. With a clinical trial of its first clinical candidate already underway, trials of its second and third clinical candidates slated to begin in the next two quarters, and additional product candidates advancing in the expanding pipeline, Torque has enormous potential to create value in the near term and beyond."

Cox became Executive Chairman of Torque in January, 2019. During his tenure as Executive Chairman, Torque successfully transitioned from a pre-clinical to a clinical stage company, advanced multiple product candidates in its pipeline, expanded its team with key hires in business development and finance, received Fast Track designation for its lead TRQ-1501 product, and announced a collaboration with Thermo Fisher Scientific to manufacture Torque’s Deep Primed T Cell immunotherapies, as well as a clinical trial collaboration with Merck to evaluate its lead TRQ-1501 product in combination with Keytruda.

Celldex Therapeutics Announces Upcoming Data Presentations

On October 2, 2019 Celldex Therapeutics, Inc. (NASDAQ:CLDX) reported that multiple Company drug development programs will be the subject of presentations at upcoming medical and scientific conferences (Press release, Celldex Therapeutics, OCT 2, 2019, View Source [SID1234540023]).

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Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 34th Annual Meeting & Pre-Conference Programs (SITC 2019), November 6-10 in National Harbor, Maryland

CDX-1140: The abstract (Abstract ID: P827) entitled, "Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX-301 (rhFLT3L) in patients with advanced cancers" will be presented in a poster presentation by Rachel Sanborn, MD, Co-director of the Thoracic Oncology Program and Leader of the Phase 1 Trials Program at Providence Cancer Institute and a lead investigator in this study, on Friday, November 8, 2019 from 8:00 am to 8:00 pm ET. Michael Yellin, MD, Vice President of Clinical Science at Celldex will also present a talk entitled CD40: A Target for Systemic Immune Modulation at the Workshop on Intratumoral Immunomodulation on Thursday, November 7, 2019 at 3:00 pm ET.

CDX-527: The abstract (Abstract ID: P700) entitled, "Combining CD27 costimulation and PD-1 blockade into a bispecific antibody improves T cell activation and anti-tumor activity over combination of individual antibodies" will be presented in a poster presentation by Tibor Keler, PhD, Executive Vice President and Chief Scientific Officer at Celldex, on Saturday, November 9, 2019 from 8:00 am to 8:00 pm ET. This program will also be highlighted in a short talk by Dr. Keler during the preconference program session "Novel Multi-Targeted Therapeutic Platforms" on Wednesday, November 6, 2019 at 4:45 pm ET.

American College of Allergy, Asthma & Immunology Annual Scientific Meeting, November 7-11 in Houston, Texas

CDX-0159: The abstract (Abstract ID: 8071) entitled, "CDX-0159, An Anti-KIT Monoclonal Antibody, As A Modulator of Mast Cell-related Diseases" has been accepted for presentation by Richard Gedrich, PhD, Executive Director of Translational Medicine at Celldex, in the Distinguished Industry Oral Abstract Session on Saturday, November 9, 2019 at 4:35 pm CT.

Copies of these presentations will be made available on the Celldex website after presentation.

Iovance Biotherapeutics Announces Four Abstracts to be Presented at the Upcoming 2019 SITC Annual Meeting

On October 2, 2019 Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a late-stage biotechnology company developing novel cancer immunotherapies based on tumor-infiltrating lymphocyte (TIL) technology, reported that four abstracts highlighting its TIL therapy will be presented at the upcoming Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 34th Annual Meeting from November 6-10, 2019 in National Harbor, Maryland (Press release, Iovance Biotherapeutics, OCT 2, 2019, View Source [SID1234540022]). One of the abstracts is a late-breaking submission and presentation details will be made available to the public on November 1, 2019. Details on the three posters that will be presented as part of the regular submissions are below.

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Title: Expanding Iovance’s tumor infiltrating lymphocytes (TIL) from core biopsies for adoptive T cell therapy using a 22-day manufacturing process
Author: Abelson et al.
Poster #: P145
Presentation date/time: November 8, 2019, 7:00 am – 8:00 pm

Title: Silencing PD-1 using self-delivering RNAi PH-762 to improve Iovance TIL effector function using Gen 2 manufacturing method
Author: Azoulay-Alfaguter et al.
Poster #: P149
Presentation date/time: November 8, 2019, 7:00 am – 8:00 pm

Title: Iovance Gen2 TIL manufacturing process produces drug products that exhibit favorable quality attributes for adoptive cell transfer across 5 solid tumor indications
Author: Wardell et al.
Poster #: P226
Presentation date/time: November 9, 2019, 7:00 am – 8:30 pm

The SITC (Free SITC Whitepaper) abstract titles are listed on the conference website under Abstracts at View Source

Viela Bio Announces Pricing of Initial Public Offering

On October 2, 2019 Viela Bio, Inc., a clinical-stage biotechnology company pioneering treatments for autoimmune and severe inflammatory diseases, reported the pricing of its initial public offering of 7,900,000 shares of its common stock at a price to the public of $19.00 per share (Press release, Viela Bio, OCT 2, 2019, View Source [SID1234540021]). The gross proceeds to Viela Bio from the offering, before deducting the underwriting discounts and commissions and offering expenses, are expected to be approximately $150 million. The shares are expected to begin trading on the Nasdaq Global Select Market on October 3, 2019 under the symbol "VIE." The offering is expected to close on October 7, 2019, subject to customary closing conditions. In addition, Viela Bio has granted the underwriters a 30-day option to purchase up to an additional 1,185,000 shares of common stock at the initial price to the public less underwriting discounts.
Goldman Sachs & Co. LLC, Morgan Stanley & Co. LLC, and Cowen and Company, LLC are acting as the joint book-running managers for this offering. Guggenheim Securities, LLC is acting as lead manager for this offering.

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The offering will be made only by means of a prospectus. Copies of the final prospectus related to the offering, when available, may be obtained from:

Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, email: [email protected], telephone: 1-866-471-2526, fax: 1-212-902-9316;
Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, Second Floor, New York, NY 10014; or
Cowen and Company, LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, Attention: Prospectus Department, email: [email protected], telephone: 1-833-297-2926.
Registration statements relating to these securities have been filed with the Securities and Exchange Commission and became effective on October 2, 2019. This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.