Entry into a Material Definitive Agreement

On September 27, 2019, Rigel Pharmaceuticals, Inc., a Delaware corporation (the "Company") reported that it entered into a Credit and Security Agreement, dated as of September 27, 2019 (the "Closing Date") by and among the Company, the lenders party thereto from time to time and MidCap Financial Trust, as administrative agent and collateral agent ("Agent") (the "Term Loan Credit Agreement"), which provides for a $60 million term loan facility (Filing, 8-K, Rigel, SEP 27, 2019, View Source [SID1234552181]). The Term Loan Credit Agreement provides for (i) on the Closing Date, $10.0 million aggregate principal amount of term loans, (ii) at the Company’s option, until December 31, 2020, an additional $10.0 million term loan facility, (iii) at the Company’s option, until March 31, 2021, an additional $20.0 million term loan facility subject to the satisfaction of certain conditions ("Tranche Three") and (iv) at the Company’s option, until March 31, 2022, an additional $20.0 million term loan facility subject to the satisfaction of certain conditions ("Tranche 4") (collectively, the "Term Loans"). The Company used the proceeds of the Term Loans for general corporate purposes

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The obligations under the Term Loan Credit Agreement are secured by a perfected security interest in all of the Company’s assets except for intellectual property and certain other customary excluded property pursuant to the terms of the Term Loan Credit Agreement.

The Term Loans are subject to an origination fee of 0.25% of each funded tranche of Term Loans. The Company will pay the Agent an annual administrative fee of 0.25% of the amount borrowed under the Term Loans, payable annually. The Term Loans may be prepaid in full or in part through September 27, 2020 with payment of a 2.5% prepayment premium, after which they may be prepaid in full or in part through September 27, 2021 with payment of a 1.5% prepayment premium, after which they may be prepaid in full or in part through September 27, 2022 with payment of a 1.0% prepayment premium, after which they may be prepaid in full or in part with no prepayment premium. An additional 2.5% of the amount of Terms Loans advanced by the lenders will be due upon prepayment or repayment of the Term Loans in full.

The interest rate applicable to the Term Loans is LIBOR plus 5.65%, subject to a LIBOR floor of 1.50%. Commencing October 1, 2019, the Company initially will make interest-only payments for 24 months, followed by 36 months of amortization payments. The interest-only period will be extended to 36 months and again to 48 months upon the satisfaction of certain conditions set forth in the Term Loan Credit Agreement. All unpaid principal and accrued interest is due and payable in full no later than September 1, 2024.

The Term Loan Credit Agreement requires that the Company (i) upon both of (x) the draw of Tranche 3 or Tranche 4 and (y) cash falling below 1.25x Term Loans outstanding, maintain U.S. Tavalisse Net Revenue (as defined in the Term Loan Credit Agreement) in amounts set forth in the Term Loan Credit Agreement and (ii) upon the draw of Tranche 3 or Tranche 4, maintain cash and cash equivalents of at least $10.0 million. The Term Loan Credit Agreement also contains customary representations and warranties and customary affirmative and negative covenants, including, among other things, restrictions on indebtedness, liens, investments, mergers, dispositions, prepayment of other indebtedness and dividends and other distributions.

Events of default under the Term Loan Credit Agreement include: (i) failure by the Company to timely make payments due under the Term Loan Credit Agreement; (ii) material misrepresentations or misstatements in any representation or warranty by the Company when made; (iii) failure by the Company or its subsidiaries to comply with the covenants under the Term Loan Credit Agreement and other related agreements; (iv) certain defaults under a specified amount of other indebtedness of the Company or its subsidiaries; (v) insolvency or bankruptcy-related events with respect to the Company or any of its subsidiaries; (vi) certain undischarged judgments against the Company or its subsidiaries; (vii) certain ERISA-related events with respect to the Company or its subsidiaries above a specified amount; (viii) certain security interests or liens under the loan documents ceasing to be, or being asserted by the Company not to be, in full force and effect; (ix) the institution of criminal proceedings against the Company; (x) an event of default under the guarantee of the obligations under the Term Loan Credit Agreement; (xi) the prepayment of any subordinated debt other than as specifically permitted by the terms of such subordination; (xii) the occurrence of a Material Adverse Change (as defined in the Term Loan Credit Agreement); (xiii) certain adverse actions by the FDA or DEA with respect to certain products or which could be reasonably expected to result in a Material Adverse Change (as defined in the Term Loan Credit Agreement); (xiv) a default or material breach under certain specified material contracts and (xv) any loan document ceasing to be, or any challenge or assertion by the Company that such loan document is not, in full force and effect. If one or more events of default occurs and continues beyond any applicable cure period, the Agent may, with the consent of the lenders holding a majority of the loans and commitments under the facilities, or will, at the request of such lenders, terminate the commitments of the lenders to make further loans and declare all of the obligations of the Company under the Term Loan Credit Agreement to be immediately due and payable.

Upstate professors to present at international cancer conference in Spain

On September 27, 2019 Three Upstate Medical University professors reported that it will present work at the world’s second-largest cancer conference starting this weekend in Spain (Press release, SUNY Upstate, SEP 27, 2019, View Source [SID1234551517]).

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Jeffrey Ross, MD, Jeffrey Bogart, MD, and Gennady Bratslavsky, MD, will attend the annual European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress, Sept. 27 to Oct. 1 in Barcelona, Spain. About 30,000 cancer specialists gather at ESMO (Free ESMO Whitepaper) each fall. It is an opportunity for oncology experts from around the world to share their latest research and findings.

"Many breakthroughs in anti-cancer drug trials are now being presented at the ESMO (Free ESMO Whitepaper) meeting," said Ross, an assistant professor of pathology at Upstate and medical director of Foundation Medicine in Cambridge, Massachusetts. Ross, who has attended ESMO (Free ESMO Whitepaper) many times over the years, said he is involved in eight Upstate projects that will be either presented or addressed at ESMO (Free ESMO Whitepaper). His recent research into a particularly deadly type of cancer called Carcinoma of Unknown Primary (CUP) site, will be presented by a colleague at this year’s Congress and is being highlighted by the organization as a significant study.

CUP affects about one in 15 patients with cancer. CUP patients are diagnosed when the cancer has already spread and no primary tumor can be located. Only one in 10 CUP patients survive for one year.

Ross is first author on the study, which showed that about one in three patients with CUP may be a candidate for targeted treatment or immunotherapy based on DNA changes in the tumor. Ross said a colleague will present the study and he will be available to answer questions. This paper is a follow-up to one that was published in 2015, Ross said.

"That paper allowed pharma to initiate a $100 million clinical trial to enroll patients for treatment based on the genomic findings of their cancer," he said.

Bogart, interim director of the Upstate Cancer Center, will present on "interim toxicity analysis for patients with limited stage small cell lung cancer (LSCLC) treated on the experimental thoracic radiotherapy (TRT) arms of CALGB 30610 (Alliance.)" And Bratslavsky, chair of Upstate’s urology department, will present on malignant pheochromocytoma and malignant paraganglioma.

Bogart said his research is based on a 10-year study of more than 700 patients throughout the country – including many treated at Upstate. The study involved varying radiation treatment plans for patients with small cell lung cancer.

"The trial is completed and we will have to follow up with these patients over the next several years," Bogart said. "The final question is one we don’t have the answer to yet and that is the best way to give radiation, which will have a big impact for how patients are treated in the future."

Bogart and Ross said Upstate’s involvement at an international conference like ESMO (Free ESMO Whitepaper) helps to further establish Upstate as a leader in cancer research.

"It’s exciting for Upstate Cancer Center to be a significant source of new information for cancer patients and to be on the cutting edge of this kind of cancer genomics research," Ross said. "It’s hopefully going to make the breadth of cancer work done at Upstate more well known. We’re doing more than just treating cancer patients. We’re doing basic and clinical research trying to help patients not just in Syracuse but everywhere."

Iovance Biotherapeutics to Present at Upcoming Conferences

On September 27, 2019 Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a late-stage biotechnology company developing novel cancer immunotherapies based on tumor-infiltrating lymphocyte (TIL) technology, reported that the company plans to present at the following conferences (Press release, Iovance Biotherapeutics, SEP 27, 2019, View Source [SID1234539886]):

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EPPICon 2019 Annual Conference in Santa Clara, Calif., Sept. 28, 2019
Location: Santa Clara Convention Center
Date/Time: Saturday, Sept. 28, at 11:10 a.m. PDT
Cell & Gene Meeting on the Mesa in Carlsbad, Calif., Oct. 2-4, 2019
Location: Park Hyatt Aviara Resort
Date/Time: Thursday, Oct. 3, at 5:30 p.m. PDT
2019 Cantor Global Healthcare Conference in New York, Oct. 2-4, 2019
Location: InterContinental New York Barclay
Date/Time: Thursday, Oct. 3, at 3:35 p.m. EDT
Live and archived webcasts of the Cell & Gene Meeting on the Mesa and 2019 Cantor Global Healthcare Conference presentations will be available in the Investors section of the Iovance website at View Source

Aridis Pharmaceuticals to Present at the 2019 Cantor Global Healthcare Conference

On September 27, 2019 Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS), a biopharmaceutical company focused on the discovery and development of novel anti-infective therapies to treat life-threatening bacterial infections, reported that Vu Truong, Ph.D., Chief Executive Officer, will present at the 2019 Cantor Global Healthcare Conference on Friday, October 4, 2019 at 11:15 am ET (Press release, Aridis Pharmaceuticals, SEP 27, 2019, View Source [SID1234539867]). The conference will be held at the InterContinental New York Barclay in New York City.

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A webcast of the live presentation will be available at View Source A replay will be available on the Company’s website for 90 days.

Eiger to Present at Cantor 2019 Global Healthcare Conference

On September 27, 2019 Eiger BioPharmaceuticals, Inc. (Nasdaq: EIGR), focused on the development and commercialization of targeted therapies for serious rare and ultra-rare diseases, reported that Eiger management will present a corporate update at the Cantor 2019 Global Healthcare Conference on October 4, 2019 from 8:55-9:25 AM ET in New York City (Press release, Eiger Biopharmaceuticals, SEP 27, 2019, View Source [SID1234539866]).

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A live webcast of the presentation will be available on the Eiger BioPharmaceuticals website at www.eigerbio.com under the "Investors" tab. A replay of the webcast will be available approximately one hour following the completion of the live event.

Eiger will also host one-on-one meetings with investors.