Novocure Announces National Reimbursement in Israel for Optune® in Combination with Temozolomide for the Treatment of Newly Diagnosed Glioblastoma

On January 21, 2020 Novocure (NASDAQ: NVCR) reported that the State of Israel Ministry of Health has added Optune in combination with temozolomide to the Israeli medical services basket for the treatment of patients with newly diagnosed glioblastoma (Press release, NovoCure, JAN 21, 2020, View Source [SID1234553377]). The medical services basket includes the entire range of services, medications and devices that the insured public in Israel is entitled to receive under the National Health Insurance Law.

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"We are extremely pleased that the Ministry of Health has established national reimbursement for Optune in Israel," said Anat Bin, Novocure’s Country Manager of Israel. "Access to our therapy continues to grow throughout the world, demonstrating health insurers’ increasing recognition of Optune. We are committed to bringing Optune to as many patients who may benefit."

Calidi Biotherapeutics Secures Series A Investments to Advance Manufacturing

On January 21, 2020 Calidi Biotherapeutics, Inc., a clinical‐stage immuno-oncology company at the forefront of cell-based oncolytic virus immunotherapies for cancer, reported Series A investments from two South Korean firms to advance manufacturing in preparation for Calidi’s pre-IND and IND filings (Press release, Calidi Biotherapeutics, JAN 21, 2020, View Source [SID1234553376]).

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The investment efforts were led by Heehyoung Lee, Ph.D., co-founder and managing partner of LumeBio, advisor to Calidi Biotherapeutics and a fifteen-year veteran in the biopharmaceutical space. Dr. Lee facilitated the relationships between Calidi Biotherapeutics and the South Korean investment firms: Won & Partners and Greentable Co., Ltd.

"We are excited to grow Calidi Biotherapeutics and further our mission to bring lifesaving treatments to cancer patients." said Allan Camaisa, CEO of Calidi Biotherapeutics. "Dr. Lee and Lumebio have been instrumental in helping us close out our series A raise. This funding will allow us to continue advancing our manufacturing processes as we prepare our pre-IND and IND package for Supernova 1 (SNV1c), a tumor-selective vaccinia virus combined with allogeneic adipose-derived mesenchymal stem cells (AD-MSC). We are excited to advance this asset into the clinic to target multiple cancer types."

"The promise of oncolytic viral therapy has yet to be fulfilled," said Heehyoung Lee, Ph.D., "Calidi’s unique allogeneic stem cell delivery platform utilizing adipose tissue will revolutionize the field of oncolytic viruses."

Dr. Lee previously held positions at Hanmi Pharmaceuticals, Sorrento Therapeutics, and City of Hope. Upon completing her Ph.D. in Pathology & Molecular Medicine in 2002, Dr. Lee received the American Heart Association Fellowship and held a postdoctoral position at Moffitt Cancer Center. Dr. Lee became an Assistant Professor at City of Hope, where she focused on tumor immunobiology and cancer. She led the seminal findings in linking lipid metabolism to JAK-STAT-driven cancer, which is published in Nature Medicine and Nature Reviews Cancer. Her extensive background also includes global strategic planning and alliance management with Sanofi, Genentech, and Eli Lilly.

Novigenix-Led Consortium Secures Eurostars Funding to Develop Multi-Omics Test for Colon Cancer Detection and Monitoring

On January 21, 2020 Novigenix SA, a leading Immuno-Transcriptomics company that develops and commercializes solutions for early cancer detection and precision medicine, reported that a consortium, including Maastricht University (The Netherlands), Biolizard and the KU Leuven (Belgium), in addition to Novigenix, has been awarded a grant up to €1 million to develop a blood based multi-omics colorectal cancer (CRC) test (Press release, Novigenix, JAN 21, 2020, View Source [SID1234553375]).

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The aim of the consortium is to develop a blood based test based on transcriptomic and epigenetic biomarkers for early detection and relapse monitoring in CRC patients. The biomarker development strategy will leverage transcriptome profiling of whole blood and candidate tumor DNA methylation markers in cell free-DNA. Moreover, the consortium will develop an automated and structured data analysis process, including the most advanced machine learning methods, and validate multi-omics signatures.

The members of consortium balanced between industrial and academic partners. Novigenix’s will leverage its core competencies of the Immuno-Transcriptomics technology and Biolizard will focus on biological data integration, bioinformatics analysis, pipeline implementation and will provide artificial intelligence solutions. The group of Prof. dr. Manon van Engeland at Maastricht University brings unique expertise on CRC DNA methylation, whereas the Molecular Digestive Oncology group of Prof. dr. Sabine Tejpar at KU Leuven adds a clinical network for prospective collection of biological specimens and data interpretation.

"This Eurostars project combines excellent, world-leading science and technologies in a consortium dedicated to making significant advances in how colorectal cancer is detected and its treatment monitored," said Dr. Jan Groen, CEO of Novigenix. "We believe the outcome of this project, a potential omics-based test, will be important for the diagnosis and disease management of CRC patients."

About Eurostars

Eurostars supports international innovative projects led by research and development- performing small- and medium-sized enterprises (R&D-performing SMEs). With its bottom-up approach, Eurostars supports the development of rapidly marketable innovative products, processes and services that help improve the daily lives of people around the world. Eurostars is a joint program between EUREKA and the European Commission, co-funded from the national budgets of 36 Eurostars Participating States and Partner Countries and by the European Union through Horizon 2020. For more information visit View Source

Advaxis, Inc. Announces Pricing Of $10.5 Million Registered Direct Offering

On January 21, 2020 Advaxis, Inc. (Nasdaq: ADXS) (the "Company"), a clinical-stage biotechnology company focused on the development and commercialization of immunotherapy products, reported it has entered into a definitive agreement with two institutional investors for the purchase and sale of 10,000,000 shares of the Company’s common stock at an offering price of $1.05 per share, for gross proceeds of $10.5 million before deducting fees and other estimated offering expenses, pursuant to a registered direct offering (the "Offering") (Press release, Advaxis, JAN 21, 2020, View Source [SID1234553374]). The Company has also agreed to issue to those investors, in a concurrent private placement, unregistered common share purchase warrants to purchase 5,000,000 shares of the Company’s common stock. The warrants will be exercisable on the six-month anniversary of issuance and will have a five-year term and an exercise price of $1.25 per share.

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The Company expects to use the net proceeds from the Offering to fund its continued research and development initiatives in connection with its product pipeline including, but not limited to, in its ADXS-HOT program and potential new studies for its ADXS-PSA drug candidate, and for general corporate purposes. The Offering is expected to close on or about January 23, 2020, subject to the satisfaction of customary closing conditions.

A.G.P./Alliance Global Partners is acting as sole placement agent for the Offering.

This offering is being made pursuant to an effective shelf registration statement on Form S-3 (File No. 333-226988) previously filed with the U.S. Securities and Exchange Commission (the "SEC"), and an additional registration statement on Form S-3 filed pursuant to Rule 462(b) under the Securities Act, which became effective upon filing on August 30, 2018. A prospectus supplement describing the terms of the proposed offering will be filed with the SEC and will be available on the SEC’s website located at www.sec.gov. Electronic copies of the prospectus supplement may be obtained, when available, from A.G.P./Alliance Global Partners, 590 Madison Avenue, 36th Floor, New York, NY 10022 or via telephone at 212-624-2006 or email: [email protected]. Before investing in this offering, interested parties should read in their entirety the prospectus supplement and the accompanying prospectus and the other documents that the Company has filed with the SEC that are incorporated by reference in such prospectus supplement and the accompanying prospectus, which provide more information about the Company and such offering. Copies of the Supplement, the Base Shelf Prospectus and the Registration Statement may also be obtained from A.G.P./Alliance Global Partners, 590 Madison Avenue, 36th Floor, New York, NY 10022 or via telephone at 212-624-2060 or email: [email protected].

No securities regulatory authority has either approved or disapproved of the contents of this press release. This press release is for information purposes only and shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Seattle Genetics to Host Conference Call and Webcast Discussion of Fourth Quarter and Full Year 2019 Financial Results on February 6, 2020

On January 21, 2020 Seattle Genetics, Inc. (Nasdaq: SGEN) reported that it will report its fourth quarter and full year 2019 financial results on Thursday, February 6, 2020 after the close of financial markets (Press release, Seattle Genetics, JAN 21, 2020, View Source [SID1234553373]). Following the announcement, company management will host a conference call and webcast discussion of the results and provide a general corporate update. Access to the event can be obtained as follows:

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LIVE access on Thursday, February 6, 2020
1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time

Telephone 800-353-6461 (domestic) or +1 334-323-0501 (international); conference ID 7290215
Webcast with slides available at www.seattlegenetics.com in the Investors section
REPLAY access

Telephone replay will be available beginning at approximately 4:30 p.m. PT on Thursday, February 6, 2020 through 5:00 p.m. PT on Sunday, February 9, 2020 by calling 888-203-1112 (domestic) or +1 719-457-0820 (international); conference ID 7290215
Webcast replay will be available on the Seattle Genetics website at www.seattlegenetics.com in the Investors section