Bio-Path Holdings Announces $4.0 Million Private Placement Priced At-the-Market Under Nasdaq Rules

On June 4, 2024 Bio-Path Holdings, Inc. (NASDAQ:BPTH) ("Bio-Path" or the "Company"), a biotechnology company leveraging its proprietary DNAbilize liposomal delivery and antisense technology to develop a portfolio of targeted nucleic acid cancer drugs, reported that it has entered into a definitive agreement for the issuance and sale of an aggregate of 1,809,955 shares of its common stock (or common stock equivalents in lieu thereof), series A warrants to purchase up to 1,809,955 shares of common stock and short-term series B warrants to purchase up to 1,809,955 shares of common stock at a purchase price of $2.21 per share of common stock (or per common stock equivalent in lieu thereof) and accompanying warrants in a private placement priced at-the-market under Nasdaq rules (Press release, Bio-Path Holdings, JUN 4, 2024, View Source [SID1234644079]). The series A warrants and short-term series B warrants will have an exercise price of $2.00 per share and will be exercisable immediately upon issuance. The series A warrants will expire five years from the date of issuance and the short-term series B warrants will expire twenty-four months from the date of issuance. The closing of the offering is expected to occur on or about June 5, 2024, subject to the satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

The gross proceeds to the Company from the offering are expected to be approximately $4.0 million, before deducting the placement agent’s fees and other offering expenses payable by the Company, and excluding the proceeds, if any, from the exercise of the warrants. The Company currently intends to use the net proceeds from the offering for working capital and general corporate purposes.

The securities described above are being offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Securities Act"), and/or Regulation D promulgated thereunder and, along with the shares of common stock underlying the warrants, have not been registered under the Securities Act, or applicable state securities laws. Accordingly, the securities described above, including the shares of common stock underlying the warrants, may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws. Pursuant to a registration rights agreement, the Company has agreed to file a resale registration statement covering the securities described above.

This press release does not constitute an offer to sell or a solicitation of an offer to buy the securities in this offering, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

BeiGene to Present at the Goldman Sachs 45th Annual Global Healthcare Conference

On June 4, 2024 BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global oncology company, reported the Company will participate in the Goldman Sachs 45th Annual Global Healthcare Conference on Tuesday, June 11, 2024 with a fireside chat at 1:20 pm EDT (Press release, BeiGene, JUN 4, 2024, View Source [SID1234644078]).

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Live webcast of this event can be accessed from the investors section of BeiGene’s website at View Source, View Source, View Source Archived replay will be available for 180 days following the event.

Ascendis Pharma to Participate in the Goldman Sachs 45th Annual Global Healthcare Conference

On June 4, 2024 Ascendis Pharma A/S (Nasdaq: ASND) reported that company executives will participate in a fireside chat at the Goldman Sachs 45th Annual Global Healthcare Conference on Tuesday, June 11, 2024, at 8:00 a.m. ET in Miami, Florida (Press release, Ascendis Pharma, JUN 4, 2024, View Source [SID1234644077]).

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A live webcast of the fireside chat will be available via the Investors & News section of the Ascendis Pharma website at investors.ascendispharma.com. A webcast replay will also be available on this website shortly after conclusion of the event for 30 days.

Akari Therapeutics Secures $7.6 Million in Upsized Financing Round

On June 4, 2024 Akari Therapeutics Plc (Nasdaq: AKTX), an innovative biotechnology company advancing therapies for autoimmune and inflammatory diseases, reported the successful initial closing of a private placement financing round (Press release, Akari Therapeutics, JUN 4, 2024, View Source [SID1234644076]). This transaction is expected to raise an aggregate of approximately $7.6 million in gross proceeds from both new and existing investors.

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"We are pleased to announce this financing for Akari Therapeutics," said Samir R. Patel, MD, Interim President and CEO of Akari Therapeutics. "The overwhelming interest from investors allowed the company to upsize the transaction to $7.6 million and highlights the excitement surrounding our science and the strategic direction of the company, and our merger with Peak Bio, which we expect to close in the third quarter of 2024."

The majority of the private placement financing was supported by new investors, with continued support from certain existing investors, led by Akari’s Chairman, Dr. Ray Prudo, and Interim President and CEO, Samir R. Patel, MD, underscoring their strong confidence in the company’s future. "I believe investors share our enthusiasm for the Akari-Peak go-forward strategy and combined scientific potential. The financing supports investors’ belief in our strategic vision and the future of our combined companies and the management team," added Dr. Patel.

The company entered into a definitive agreement for the private placement with the investors on May 29, 2024, pursuant to which the Company agreed to sell and issue an aggregate of 4,029,754 unregistered American Depository Shares ("ADSs"), each representing 2,000 of the Company’s ordinary shares, and Series C Warrants (the "warrants") to purchase up to 4,029,754 ADSs, at a per unit price of $1.885 per ADS and warrant. The warrants have a term of 3 years from the closing date of the private placement and have cashless exercise provisions. The warrants (other than those issued to Dr. Ray Prudo and Samir R. Patel, M.D.) have an exercise price of $1.76 per ADS, which is equal to the Nasdaq have an exercise price of $1.76 per ADS, which is equal to the Nasdaq official closing price of the Company’s ADSs on the Nasdaq Capital Market on May 29, 2024. The warrants issued to Dr. Ray Prudo and Samir R. Patel, M.D., have an exercise price of $1.79 per ADS, which is equal to the price at which the Company’s ADSs were last sold on the Nasdaq Capital Market on May 29, 2024.

In connection with the initial closing of the private placement on May 31, 2024, the Company received gross proceeds of approximately $7.2 million, and issued 3,817,553 unregistered ADSs and warrants to purchase up to an aggregate of 3,817,553 ADSs. The remaining 212,201 ADSs and warrants to purchase up to 212,201 ADSs are expected to be issued and sold by the Company within 90 days of May 31, 2024, subject to receipt of payment related thereto.

Paulson Investment Company LLC acted as the exclusive placement agent for the financing.

The securities described above were offered and sold in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act") and Regulation D promulgated thereunder and have not been registered under the Act or state securities laws and may not be offered or sold in the United States absent registration with the Securities and Exchange Commission or an applicable exemption from such registration requirements.

No Offer or Solicitation
This communication is not intended to and shall not constitute an offer to subscribe for, buy or sell or the solicitation of an offer to subscribe for, buy or sell any securities, or a solicitation of any vote or approval, nor shall there be any sale of, or offer to sell or buy, securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. This communication is for informational purposes only. No offering of securities shall be made, except by means of a prospectus meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended, and otherwise in accordance with applicable law.

Results presented at ASCO demonstrating the synergy of PharmaMar’s combination of lurbinectedin with irinotecan in patients with relapsed small cell lung cancer

On June 4, 2024 PharmaMar (MSE:PHM) reported data from a Phase II trial evaluating PharmaMar’s lurbinectedin in combination with irinotecan in patients with relapsed Small Cell Lung Cancer (SCLC) after prior platinum-based treatment at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) meeting, which took place from 31st May to 4th June in Chicago, United States (Press release, PharmaMar, JUN 4, 2024, View Source [SID1234644032]).

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The results show that combining these two drugs produces a synergy that enhances the activity of lurbinectedin, resulting in high and durable response rates in populations that are sensitive, with a chemotherapy-free interval greater than 90 days (CTFI> 90 days), and platinum-resistant with a chemotherapy-free interval of less than 90 days (CTF< 90 days).

Particularly encouraging are the data drawn from the subgroup of 74 patients with a chemotherapy-free interval greater than 30 days (CTFI>30 days) with a response rate of 52.7% and a median response duration of 7.6 months. Among the study data within this subgroup, the overall survival (OS) data is also encouraging, with a median of 12.7 months. The safety profile has proven to be manageable with a low percentage of treatment interruptions.

Dr. Luis Paz-Ares Rodríguez, Head of Medical Oncology at the "Hospital Universitario 12 de Octubre" commented: "although both irinotecan and lurbinectedin have demonstrated activity separately in monotherapy in SCLC, these compounds with different mechanisms of action have shown an important synergy when combined". The encouraging results in the population referenced in the LAGOON trial (sensitive and resistant patients, CTFI>30d) reinforce the rationale for including this combination as an experimental arm with this type of patient in the ongoing pivotal trial.