Trovagene Announces $5.0 Million Private Placement Priced At-the-Market

On October 25, 2019 Trovagene, Inc. (Nasdaq: TROV), a clinical-stage, Precision Cancer Medicine oncology therapeutics company developing drugs that target cell division (mitosis) for the treatment of various cancers including prostate, colorectal and leukemia, reported that it has entered into definitive agreements with institutional investors for the sale of 2,756,340 shares of common stock (or common stock equivalents), series G warrants to purchase up to 2,756,340 shares of common stock, and series H warrants to purchase up to 2,756,340 shares of common stock in a private placement at a price of $1.814 per share and associated warrants for gross proceeds of approximately $5.0 million (Press release, Trovagene, OCT 25, 2019, View Source [SID1234542539]). The transaction is anticipated to close on or about October 29, 2019, subject to customary closing conditions.

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H.C. Wainwright & Co. is acting as exclusive placement agent for the offering.

The series G warrants are exercisable immediately with a term of five and one-half years and an exercise price of $1.56 per share. The series H warrants are exercisable immediately with a term of 18 months and an exercise price of $1.56 per share.

Trovagene intends to use the net proceeds of the private placement to fund clinical development activities and for working capital and general corporate purposes. The Company has agreed to file a resale registration statement for the shares of common stock and the shares of common stock underlying the warrants issued in the offering within 10 days pursuant to a registration rights agreement.

The securities sold in the private placement have not been registered under the Securities Act of 1933, as amended, or state securities laws and may not be offered or sold in the United States absent registration with the Securities and Exchange Commission (SEC) or an applicable exemption from such registration requirements.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

Further information regarding the private placement can be found in the Current Report on Form 8-K that will be filed by the Company with the SEC.

SFA Therapeutics, Inc. To Present At The Microbiome R&D and Business Collaboration Forum

On October 25, 2019 SFA Therapeutics, Inc. reported that Dr. Ira Spector, company CEO, will report on updates in the company’s clinical development plans for several new therapeutic agents they have derived from the human microbiome (Press release, SFA Therapeutics, OCT 25, 2019, View Source [SID1234542538]). The presentation will be delivered as part of the Microbiome R&D and Business Collaboration Forum on October 29th at 5:45PM at the Paradise Point Resort & Spa in San Diego, CA.

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IDEAYA Biosciences to Present at Upcoming Investor Conferences

On October 25, 2019 IDEAYA Biosciences, Inc. (NASDAQ: IDYA), an oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics for patient populations selected using molecular diagnostics, reported that the company is scheduled to present in the following investor conferences (Press release, Ideaya Biosciences, OCT 25, 2019, View Source [SID1234542537]):

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Stifel 2019 Healthcare Conference in New York City, NY. The company is scheduled to present on Wednesday, November 20th at 3:35 pm ET (12:35 pm PST)
Jefferies 2019 London Healthcare Conference in London, United Kingdom. The company is scheduled to present on Thursday, November 21st at 7:20am GMT+1 (11:20 pm PST)

Allergan Declares Fourth Quarter 2019 Cash Dividend of $0.74 Per Ordinary Share

On October 25, 2019 Allergan plc (NYSE: AGN) reported that its Board of Directors has declared a cash dividend of $0.74 per ordinary share for the fourth quarter of 2019 (Press release, Allergan, OCT 25, 2019, View Source [SID1234542536]). The dividend will be paid on December 13, 2019 to shareholders of record at the close of business on November 13, 2019.

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LIPAC Oncology Announces Successful Completion of Phase 1 Bladder Cancer Clinical Study and Initiation of Phase 2A Study

On October 25, 2019 LIPAC Oncology LLC reported the successful completion of a Phase 1 clinical study and progress in a Phase 2A study to further investigate TBC-1002 for the treatment of Non-Muscle Invasive Bladder Cancer (NMIBC) (Press release, Lipac Oncology, OCT 25, 2019, View Source [SID1234542535]). Phase 1 study results showed escalating doses of TBC-1002 to be well tolerated with no dose limiting toxicity and no irritative voiding (cystitis) symptoms. No systemic exposure or toxicity was observed, even with high concentrations of TBC-1002 being delivered topically to the bladder wall. Phase 1 results also indicated preliminary efficacy with no evidence of bladder cancer recurrences observed up to 18 months after dosing. Adverse events were minor.

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TBC-1002 is a proliposomal intravesical paclitaxel formulation (PLIP), in development for intravesical administration in the treatment of non-muscle invasive bladder cancer (NMIBC). NMIBC is a common and highly recurrent disease that can often be difficult to treat. If approved, TBC-1002 would be the first chemotherapeutic agent approved by the U.S. Food and Drug Administration for this indication in more than two decades.

"We are excited about the potential of TBC-1002 to target bladder cancer directly," said Michael Oefelein, Chief Medical Officer of LIPAC. "Having treated bladder cancer for more than 23 years, it is very clear that new treatment options and more effective delivery systems could help improve both clinical outcomes and quality of life."

In August, LIPAC commenced a Phase 2A marker lesion clinical study to establish efficacy responder rates within 16 weeks, which predict long-term (two-year) recurrence free survival rates. Efficacy data from this open label study is expected as soon as November 2019 with the study results available in the first quarter of 2020.

"Having established the technology to deliver chemotherapeutic agents safely in human trials, we look forward to applying this technology in other investigational areas such as upper tract urothelial carcinoma (UTUC), ovarian cancer and peritoneal cancer," said TR Thirucote, Chairman and CEO of LIPAC.

Further results on the clinical development program for TBC-1002 will be presented at the China Biomedical Industry Cooperation Forum in Shenzhen in October and at the Society of Urologic Oncology in Washington, D.C. in December.