Arima Genomics Announces Presentation of New Data at ASCO 2026 Supporting Clinical Utility of Hi-C Sequencing in Non-Small Cell Lung Cancer

On May 27, 2026 Arima Genomics, Inc., a cancer diagnostics company bringing DNA sequence and structure together to advance cancer therapy selection, reported that it will present new data at the 2026 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place May 29-June 2 in Chicago.

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The findings in the poster presentation demonstrate the value of Arima’s Hi-C sequencing-based approach to fusion and rearrangement detection, available clinically through the Aventa FusionPlus test, for identification of clinically actionable driver alterations in patients with non-small cell lung cancer (NSCLC).

Poster Presentation Details:

Poster Board Number: 420
Title: Hi-C Sequencing Can Identify Clinically Actionable Fusions in Non-Small Cell Lung Cancer Missed by Other Sequencing Technologies
Abstract Number: 8630
Date and Time: May 31, 2026, 9:00am-12:00pm CDT
Track: Lung Cancer-Non-Small Cell Metastatic
Presenter: Kevin Levine, M.D., University of Washington/Fred Hutchinson Cancer Center, Seattle, WA.

(Press release, Arima Genomics, MAY 27, 2026, View Source [SID1234666124])

Sarah Cannon Research Institute Delivers Novel Oncology Research Insights through 155+ Accepted Abstracts & Presentations at the 2026 ASCO® Annual Meeting

On May 27, 2026 Sarah Cannon Research Institute (SCRI), one of the world’s leading oncology research organizations conducting community-based clinical trials, reported it will present new data across more than 155 abstracts and presentations at the 2026 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place in Chicago from May 29–June 2, 2026.

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The data reflect contributions from over 85 authors and coauthors across more than 30 research sites in SCRI’s network and include findings from both early- and late-phase clinical trials. These findings underscore SCRI’s role in advancing innovative therapies from first-in-human studies to practice-changing science leveraging the network’s scientific leadership and expansive community-based research footprint.

"The breadth of research presented by SCRI investigators at this year’s ASCO (Free ASCO Whitepaper) Annual Meeting reflects the unique role SCRI plays in cancer clinical research," said David R. Spigel, MD, President and Chief Medical Officer, SCRI. "Our work provides patients access to the best available research options and expert care in the communities where they live. Everyone facing cancer should have the opportunity to participate in trials with new agents without having to travel great distances away from their families and homes. We look forward to sharing our latest insights with the global oncology community in Chicago."

For a comprehensive list of SCRI abstracts and presentations, visit SCRI’s ASCO (Free ASCO Whitepaper) Site. To learn more about our research experts, visit the SCRI Leadership page.

Noteworthy Presentations

Blood Cancer & Blood Disorders

Hans Lee, MD, SCRI, will deliver "First Results from the Phase 1/2 LINKER-AL2 Trial of Linvoseltamab in Patients with Relapsed or Refractory Systemic Light Chain Amyloidosis" in an oral presentation on Friday, May 29 at 3:09 p.m. CDT during the session, Hematologic Malignancies—Plasma Cell Dyscrasia in S100a.
Peter Forsberg, MD, SCRI at Colorado Blood Cancer Institute, will present "Optec/Optal: A Phase 2 Study to Evaluate Outpatient, Step-Up Administration of Teclistamab or Talquetamab with Prophylactic Tocilizumab in Patients with Relapsed/Refractory Multiple Myeloma" in an oral presentation on Sunday, May 31 at 9:51 a.m. CDT during the session, Hematologic Malignancies—Plasma Cell Dyscrasia in E450a.
John Burke, MD, SCRI at Rocky Mountain Cancer Centers | The US Oncology Network, is coauthor on the Late Breaking Abstract, "frontMIND: Phase 3 Study of Tafasitamab plus Lenalidomide and R-CHOP for Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma" that will be presented on Saturday, May 30 at 3:00 p.m. CDT as part of the session, Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia in the Arie Crown Theater.
Breast Cancer

Erika Hamilton, MD, SCRI, will deliver "Efficacy and Safety of Tucatinib vs Placebo Combined with Trastuzumab and Pertuzumab as Maintenance Therapy for HER2+ Metastatic Breast Cancer by Stratified Subgroups" in an oral presentation on Tuesday, June 2 at 11:09 a.m. CDT as part of the session, Breast Cancer—Metastatic in Hall D1.
Mabel Mardones, MD, SCRI at Rocky Mountain Cancer Centers | The US Oncology Network, is a coauthor on the Late Breaking Abstract, "Giredestrant + Palbociclib vs Letrozole + PALBO as First-Line Therapy in Patients with Estrogen Receptor–Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer: Primary Analysis of the Phase III persevERA BC Trial" that will be presented on Tuesday, June 2 at 11:45 a.m. CDT during the session, Breast Cancer—Metastatic in Hall D1.
Lung Cancer

Melissa Johnson, MD, SCRI, is coauthor on the Late Breaking Abstract, "Event-Free Survival with Adjuvant Selpercatinib in Stage IB-IIIA RET Fusion-Positive NSCLC: Primary Results of the Phase 3 LIBRETTO-432 Trial" that will be presented during the Plenary Session on Sunday, May 31 at 2:13 p.m. CDT in Hall B1.
Melanoma & Skin Cancers

Meredith McKean, MD, MPH, SCRI, is coauthor on the Late Breaking Abstract, "Darovasertib Plus Crizotinib vs Investigator’s Choice as First-Line Treatment for Patients with HLA-A2 Negative Metastatic Uveal Melanoma: Primary Results from the OptimUM-02 Trial" that will be presented on Monday, June 1 at 9:00 a.m. CDT during the session, Melanoma/Skin Cancers in S100bc.
Additional

James Essell, MD, SCRI at OHC | The US Oncology Network, will deliver the oral "Impact of Remote Therapeutic Monitoring with Patient-Reported Outcomes on Hospitalization in Real-World Patients Receiving Therapy for Metastatic Solid Tumors" that will be presented on Sunday, May 31 at 9:24 a.m. CDT during the session, Quality Care/Health Services Research in S100bc.
Dr. Erika Hamilton and Elisa Fontana, MD, PhD, SCRI at HCA Healthcare UK, also serve on the ASCO (Free ASCO Whitepaper) Annual Meeting Scientific Program Committee; Dr. Hamilton as the Prior Annual Meeting Scientific Committee Chair and Dr. Fontana on the Gastrointestinal Cancer – Colorectal & Anal Committee.

In addition to scientific presentations, SCRI leadership will participate in and lead several ASCO (Free ASCO Whitepaper) sessions, including:

Stephen Strickland, Jr., MD, MSCI, SCRI, will offer the "Transplant Specialist Perspective" during the session, From Myelodysplastic Syndrome to Acute Myeloid Leukemia: Treatment-Related Myeloid Neoplasm Diagnosis and Therapeutic Strategies on Saturday, May 30 from 8:00 a.m. – 9:00 a.m. CDT in E450b.
Howard Burris, III, MD, SCRI, will deliver the "Top Donor Recognition Ceremony" during the Opening Session on Saturday, May 30 from 11:15 a.m. – 11:25 a.m. CDT in Hall B1.
Dr. Melissa Johnson will present "KRAS-Directed Therapy: A Clinical Update" during the ASCO (Free ASCO Whitepaper)/AACR Joint Session: The KRAS Journey – Perseverance Pays Off on Saturday, May 30 from 1:34 p.m. – 1:49 p.m. CDT in S100bc.
Debra Patt, MD, PhD, MBA, SCRI at Texas Oncology | The US Oncology Network, will present "Algorithms in Action: From Training to Practice" during the session, Oncology 2.0: How Artificial Intelligence Is Closing the Information Gap – Or Is It? on Sunday, May 31 from 10:45 a.m. – 10:57 a.m. CDT in S102.
Dr. Elisa Fontana will present "RAS in Colorectal Cancer: Mechanisms of Action, Inhibition and Resistance" during the session, Emerging and Established Targets in Colorectal Cancer: Translating Biology in Therapeutics, as well as moderate the panel Q&A, on Sunday, May 31 from 4:30 p.m. – 4:45 p.m. CDT in Hall D2.
Benjamin Garmezy, MD, SCRI, will chair the session, Rapid Oral: Genitourinary Cancer – Kidney and Bladder on Monday, June 1 at 8:00 a.m. – 9:30 a.m. CDT in Hall D2.
Dr. Erika Hamilton will serve as Chair for the session, Highlights of the Year II on Monday, June 1 at 8:00 a.m. – 9:15 a.m. CDT in Hall D1.
Dee Anna Smith, SCRI, will deliver "The Community Frontline: Scaling Rapid Activation for Real-World Impact" during the session, Time to Activation in Oncology Clinical Trials: Challenges and Opportunities for Improvement on Monday, June 1 from 8:40 a.m. – 8:55 a.m. CDT in S100a.
Additional SCRI First-Author Poster Presentations

Saturday, May 30, 2026

"Advancing Health Equity in Oncology: Virtual Collaborative Behavioral Health Engagement and Outcomes Among Medicaid-Insured and BIPOC Patients," Nina Balanchivadze, MD, SCRI at Virginia Oncology Associates | The US Oncology Network, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"Phase 1 Dose Escalation of CTX-8371, a Novel PD-1xPD-L1 Bispecific Antibody, in Patients with Advanced Malignancies Post Checkpoint Inhibition," Judy Wang, MD, SCRI at Florida Cancer Specialists & Research Institute | The US Oncology Network, 1:30 p.m. – 4:30 p.m. CDT, Hall A.
"BI-1808 + Pembrolizumab: Responses to a Chemotherapy-Free Regimen in Advanced Ovarian Cancer," Anja Williams, MD, SCRI at HCA Healthcare UK, 1:30 p.m. – 4:30 p.m. CDT, Hall A.
Sunday, May 31, 2026

"Real-World Characteristics, Homologous Recombination Repair Mutation Testing, Treatment Patterns, and Outcomes of Patients with Metastatic Castration-Sensitive Prostate Cancer in the US Community Oncology Setting," Manojkumar Bupathi, MD, MS, SCRI at Rocky Mountain Cancer Centers | The US Oncology Network, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"Combining HC-7366 with Belzutifan in Patients with Renal Cell Carcinoma to Alter Tumor and Microenvironment: Pharmacokinetic and Pharmacodynamic Analysis of a Phase 1b Study," Dr. Benjamin Garmezy, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"Imneskibart + Low-Dose Subcutaneous IL-2 ± Nivolumab in Patients with CPI-Refractory Cutaneous Melanoma: Promising Results from an Ongoing Phase 1/2 Study," Dr. Meredith McKean, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"Efficacy, Safety, and Cytokine Profiling with Addition of the Toll-Like Receptor 7/8 Dual Agonist EIK1001 to Standard of Care First-Line Therapy: The Phase 2 TeLuRide-005 Trial in Stage 4 NSCLC," Bo Wang, MD, SCRI at Willamette Valley Cancer Institute and Research Center | The US Oncology Network, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
Monday, June 1, 2026

"Evaluating the Impact of a Statewide Intervention on Multiple Myeloma Bispecific T-Cell Engaging Antibody Therapy Uptake in Florida," Maen Hussein, MD, SCRI at Florida Cancer Specialists & Research Institute | The US Oncology Network, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"Comparative Efficacy of Linvoseltamab versus Teclistamab in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma: Updated Matching-Adjusted Indirect Comparison with Longer Follow-Up," Dr. Hans Lee, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"Efficacy Prediction for Progression-Free Survival and Overall Survival by Genomic Instability Score Cutoffs in Patients with Advanced Ovarian Cancer: Post Hoc Results from the Phase 3 PRIMA/ENGOT-OV26/GOG-3012 Trial," Bradley Monk, MD, SCRI at Florida Cancer Specialists & Research Institute | The US Oncology Network, 9:00 a.m. – 12:00 p.m. CDT, Hall A.
"A Phase 1/2, First-in-Human Study of AVZO-021, a Selective Cyclin-Dependent Kinase 2 Inhibitor, as Monotherapy and in Combination for Patients with Advanced Solid Tumors, including Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer and Cyclin E1–Amplified Solid Tumors: Updated Safety and Efficacy Results," Manish R. Patel, MD, SCRI at Florida Cancer Specialists & Research Institute | The US Oncology Network, 1:30 p.m. – 4:30 p.m. CDT, Hall A.

(Press release, Sarah Cannon Research Institute, MAY 27, 2026, View Source [SID1234666123])

Archeus Technologies Doses First Patient in Phase 1 Study of ARC-706 and Companion Diagnostic ARC-166 for Metastatic Cancer

On May 27, 2026 Archeus Technologies, a clinical-stage company advancing a portfolio of differentiated small-molecule radiopharmaceutical therapies (RPTs) to address some of the most difficult-to-treat cancers, reported that it has dosed the first patient in a Phase 1 clinical trial of ARC-706, and companion diagnostic ARC-166, in patients with metastatic cancer receiving immune checkpoint inhibition (ICI) therapies.

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Archeus is developing ARC-706 for combination use with certain validated immunotherapies across a range of oncology indications. ARC-706 leverages the unique capabilities of Archeus’ NM600 tumor-targeting platform with the addition of the therapeutic beta-emitting isotope yttrium-90 (Y-90), as well as the PET isotope yttrium-86 (Y-86) comprising ARC-166. In this first-in-human imaging and therapy study, participants will receive intravenous ARC-166 for dosimetry and patient selection, followed by ARC-706 to evaluate its safety, biodistribution, pharmacokinetics, and potential to augment anti-tumor immune response. The study also aims to determine an optimal Phase 1b dose of ARC-706 and explore changes in relevant cancer-related biomarkers.

"This study allows us to evaluate a new therapeutic strategy designed to support patients who are continuing immunotherapy despite signs of disease progression," said Grace Blitzer, M.D., assistant professor of human oncology at the University of Wisconsin School of Medicine and Public Health, radiation oncologist at the UW Carbone Cancer Center, and a principal investigator of the study. "By combining functional imaging with targeted radiotherapy, we hope to demonstrate meaningful clinical benefit to patients without disrupting ongoing immune-based treatment—a goal that could have wide-reaching impact across multiple tumor types."

Preclinical studies have demonstrated tumor-selective uptake of ARC-706 in multiple cancers that are treated with ICI therapies, and that administering ARC-706 at specific dose ranges based on ARC-166 imaging results can significantly increase the response rate to ICI therapies and the durability of responses.

"By using imaging to guide therapy and selectively deliver radiation to tumors, this trial is designed to optimize treatment selection and potentially improve responses to immune checkpoint inhibitors in patients who currently face limited options," said Zachary Morris, M.D., Ph.D., chief medical officer of Archeus Technologies and co-chair of the study, as well as associate professor and chair of the Department of Human Oncology, University of Wisconsin School of Medicine and Public Health. "It also reflects our broader goal of advancing radiopharmaceutical strategies that can be applied across a range of difficult-to-treat cancers."

(Press release, Archeus Technologies, MAY 27, 2026, View Source [SID1234666122])

Forlong Announces Completion of Phase I Clinical Studies of FL115 Monotherapy (IV): Disease Control for 3 Heavily-pretreated Patients with Advanced Solid Tumors over 12 Months

On May 27, 2026 Forlong Biotechnology, a clinical-stage biotech company focusing on developing transformative cytokine therapies for patients with severe unmet needs, reported that Phase I clinical studies of FL115, an IL-15 superagonist, as monotherapy via intravenous infusion in patients with advanced solid tumors have been completed, with durable treatment effects observed in 2 patients with confirmed partial response (cPR) and 1 patient with stable disease (SD).

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Phase I clinical studies of FL115 were conducted in US and China in parallel:

FL115-101 Study was conducted in US, with 11 patients treated. One patient with advanced cervical cancer and 4 prior therapies received the 1st dose in July 2024, and achieved SD. The patient was rolled off the study in Sept 2025, and continue to receive the FL115 treatment under a Single Patient IND Protocol/Treatment Plan. Data from this study will be presented at the upcoming 2026 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting (Poster Board: 291; Session Type/Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology; Date and Time: May 30, 2026, 1:30 PM-4:30 PM CDT)

FL115-102 Study was conducted in China, with 23 patients treated. One patient with highly invasive NUT-NSCLC and 3 lines of prior therapies received the 1st dose of FL115 in Apr 2025, and achieved cPR. Another patient with lymphoepithelial carcinoma (parotid gland) and 4 lines of prior therapies received the 1st dose of FL115 in Jun 2025, and achieved cPR. Both patients have been rolled off the study respectively in March and May 2026, and continue to receive the FL115 under a Compassionate Treatment program. Data from this study was presented as a Late-breaking Abstract at 40th SITC (Free SITC Whitepaper) Annual Meeting.

FL115 (IV) is currently being investigated in combination with an anti-PD1 monoclonal antibody in a Phase 1b/2 clinical trial in patients with advanced solid tumors. Preclinical data regarding FL115 (Subcutaneous Injection) was presented at the 2026 AACR (Free AACR Whitepaper) Annual Meeting, and a Phase 1 clinical study will be initiated in 2H 2026 to evaluate FL115 (Subcutaneous Injection) in patients with advanced solid tumors. In parallel, FL115 (Intravesicale Delivery) is currently being investigated in combination with Bacillus Calmette-Guérin (BCG) in a Phase 2 clinical trial in patients with nonmuscle invasive bladder cancer (NMIBC).

"We deeply appreciate the commitment and support from the patients and their families," said Dong Wei, Ph.D., Chief Executive Officer of Forlong Biotechnology, "With favorable safety, preliminary efficacy and duration of response observed in Phase 1 clinical studies, FL115 continues to show its potential as Best-in-class IL-15 superagonist. We are advancing FL115 for multiple indications via different delivery routes, aiming to develop optimal treatment options for cancer patients in need."

About FL-115

FL115 is an engineered IL-15/IL15Rα-Fbody fusion protein, aiming to enhance anti-tumor immunity via IL-15-mediated signaling on NK and CD8+ T cells while minimizing complexity from Fc. FL115 has demonstrated significant anti-tumor activities as a monotherapy or as part of combination therapy in vivo, and can be manufactured by a robust and efficient process with excellent product stability. Clinically, FL115 has demonstrated favorable safety profile and preliminary clinical responses as a monotherapy, and has the best-in-class potential to synergize with current and emerging T cell-targeting immunotherapies through combination therapy to significantly improve the treatment outcome for patients. It is currently being investigated in combination with Bacillus Calmette-Guérin (BCG) in a Phase 2 clinical trial to evaluate safety and preliminary efficacy in patients with nonmuscle invasive bladder cancer (NMIBC) and in combination with an anti-PD1 monoclonal antibody in a Phase 1b/2 clinical trial to evaluate safety and preliminary efficacy in patients with advanced solid tumors.

(Press release, Forlong Biotechnology, MAY 27, 2026, View Source [SID1234666121])

Solu Therapeutics Granted FDA Fast Track Designation for STX-0712 for Treatment of Chronic Myelomonocytic Leukemia

On May 27, 2026 Solu Therapeutics, a biotechnology company pioneering novel therapies to eliminate disease-driving cells in cancer, immunology, and other therapeutic areas, reported that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to STX-0712, the company’s investigational therapy in development for the treatment of relapsed or refractory chronic myelomonocytic leukemia (CMML). CMML is an aggressive blood cancer with limited treatment options, particularly for patients whose disease has relapsed or become resistant to available therapies.

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Fast Track is a process designed to facilitate the development and expedite the review of drugs to treat serious conditions and fill an unmet medical need. The designation also enables more frequent interactions with the FDA throughout the development and review process.

"Fast Track designation for STX-0712 reinforces the significant need for new treatment options for people living with CMML," said Philip Vickers, President and CEO of Solu Therapeutics. "By directly depleting CCR2-positive malignant monocytes and bone marrow blasts that drive disease in CMML, STX-0712 has the potential to offer a highly specific and targeted approach. We look forward to continuing to work closely with the FDA as we advance through clinical development and work to bring this potential therapy to patients as quickly as possible."

In addition to CMML, Solu is also exploring the potential of STX-0712 in other hematologic malignancies, including acute myeloid leukemia (AML). STX-0712 is a CyTAC (Cytotoxicity Targeting Chimera) targeting the G-Protein Coupled Receptor CCR2, a selective marker expressed at high levels on malignant monocytes and bone marrow blasts, which are key drivers of disease in CMML, AML, and other hematologic cancers. By eliminating CCR2-positive cells, STX-0712 has the potential to offer a more targeted and effective treatment option with minimal effects on non-malignant cells.

The Phase 1, open-label, multicenter study evaluating STX-0712 as monotherapy in patients with relapsed or refractory CMML and AML is ongoing. It is planned that initial clinical data from this study will be submitted to a hematology conference later this year.

(Press release, Solu Therapeutics, MAY 27, 2026, View Source [SID1234666120])