On April 10, 2019 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported the pricing of an underwritten public offering in the United States of 4,200,000 American Depositary Shares ("ADSs") representing 4,200,000 ordinary shares at a public offering price of $24.00 per ADS, for total gross proceeds of approximately $100.8 million (Press release, Autolus, APR 10, 2019, View Source [SID1234535111]). All ADSs sold in the offering were offered by Autolus. In addition, Autolus has granted the underwriters a 30-day option to purchase up to an additional 630,000 ADSs at the public offering price, less underwriting discounts and commissions. The offering is expected to close on April 15, 2019, subject to customary closing conditions.

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Goldman Sachs & Co. LLC and Jefferies LLC are acting as joint book-running managers for the offering. Wells Fargo Securities, LLC and William Blair & Company, L.L.C. are acting as lead managers.

The offering will be made only by means of a prospectus. When available, copies of the final prospectus related to the offering can be obtained from either of the joint book-running managers for the offering, Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, or by telephone at +1 866 471 2526 or by email at [email protected]; or Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, or by telephone at + 1 877 821 7388 or by email at [email protected]. For the avoidance of doubt, such prospectus will not constitute a "prospectus" for the purposes of Directive 2003/71/EC (and amendments thereto, including Directive 2010/73/EU, to the extent implemented in each relevant EU member state) and will not have been reviewed by any competent authority in any EU member state.

A registration statement on Form F-1 relating to these securities was declared effective by the U.S. Securities and Exchange Commission (the "SEC") on April 10, 2019. Copies of the registration statement can be accessed through the SEC’s website at www.sec.gov. This press release does not constitute an offer to sell or the solicitation of an offer to buy securities, and shall not constitute an offer, solicitation or sale in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that jurisdiction.

On April 10, 2019 Eli Lilly and Company (NYSE: LLY) reported that it will announce its first-quarter 2019 financial results on Tuesday, April 30, 2019 (Press release, Eli Lilly, APR 10, 2019, View Source [SID1234535110]). Lilly will also conduct a conference call on that day with the investment community and media to further detail the company’s financial performance.

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The conference call will begin at 9 a.m. Eastern time. Investors, media and the general public can access a live webcast of the conference call through a link that will be posted on Lilly’s website at View Source A replay will also be available on the website following the conference call.

On April 10, 2019 I-Mab Biopharma ("I-Mab"), a clinical stage biopharmaceutical company exclusively focused on the development of potential first-in-class and best-in-class biologics in immuno-oncology and autoimmune diseases reported that it has enters into a collaboration with Roche for I-Mab’s clinical study to evaluate TJD5 in combination with atezolizumab (TECENTRIQ) (Press release, I-Mab Biopharma, APR 10, 2019, View Source [SID1234535096]).

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Roche will supply atezolizumab (TECENTRIQ) to I-Mab for use in clinical study in combination with TJD5. All rights generated in the study will belong jointly to I-Mab and Roche.

TJD5 is a proprietary innovative CD73 antibody from I-Mab’s discovery pipeline with best-in-class potential. CD73 is an ecto-enzyme expressed on stromal cells and tumors that converts extracellular adenosine monophosphate (AMP) to adenosine, which contributes to a highly immunosuppressive tumor micro-environment. On January 18, 2019, TJD5 received IND clearance from the U.S. FDA.

Dr. Joan Shen, Head of R&D of I-Mab, commented, "We are thrilled to collaborate with Roche, a global leader of cancer immunotherapy, and we look forward to maximizing the potential of TJD5 to meet the clinical needs all over the world."

About TJD5:
TJD5 is a differentiated monoclonal antibody against another promising immuno-oncology target, CD73. It is expected to stimulate the immuno-suppressive tumor micro-environment and to work in concert with other cancer therapies such as PD-1 and PD-L1 antibodies. TJD5 acts through a unique intra-dimerization mechanism for anti-cancer activities and inhibit the target enzyme activity completely. This unique mechanism of action ensures the molecule to work normally without a "hook effect" as evident in our preclinical studies.

On April 10, 2019 McKesson Corporation (NYSE:MCK) reported that it will release financial results for its fourth quarter ended March 31, 2019 on Wednesday, May 8, 2019, prior to the opening of trading on the New York Stock Exchange (Press release, McKesson, APR 10, 2019, View Source [SID1234535095]). The company has scheduled a conference call for 8:00 AM Eastern Time (5:00 AM Pacific Time), during which Brian Tyler, chief executive officer, and Britt Vitalone, executive vice president and chief financial officer, will review these results.

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The dial-in number for individuals wishing to participate on the call is 323-794-2093. Holly Weiss, senior vice president, Investor Relations is the leader of the call and the password is ‘McKesson’.

Additionally, Brian Tyler and Britt Vitalone will be participating in the Bank of America Merrill Lynch Health Care Conference on Tuesday, May 14, 2019, in Las Vegas, NV.

Audio webcasts will be available live and archived for both events on the company’s Investor Relations website at View Source A complete listing of upcoming events for the investment community is available on the company’s Investor Relations website.

On April 10, 2019 Cullgen Inc. (Cullgen), a biotechnology company dedicated to the development of targeted protein degraders for the treatment of diseases lacking effective therapeutic approaches, reported it has received a $16 million Series A financing from two prominent international venture capital firms, Sequoia Capital China (Sequoia) and Highlight Capital (HC) (Press release, Cullgen, APR 10, 2019, View Source [SID1234535094]). The financing will support the development of Cullgen’s internal pipeline of targeted protein degraders in oncology and other diseases, as well as the company’s efforts to discover novel E3 ligands that may be used as part of a targeted protein degrader complex. Sequoia will also assign a board member to join the Cullgen board.

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"We are delighted to have the support of Sequoia and HC", said Dr. Ying Luo, Chairman and President of Cullgen "Since our founding in early 2018 we have made significant advancement of our targeted protein degradation platform which has directly led to the identification of several pre-clinical assets that we are rapidly advancing towards the clinic. In addition to these core scientific advancements, over the past year the company has assembled a distinguished board of scientific advisors, put in place an outstanding senior management team, and established a state-of-the-art laboratory facility that is run by more than 40 highly talented employees. We are grateful that Sequoia and HC will be part of Cullgen’s mission to develop novel targeted protein degraders for the treatment of debilitating diseases."