On February 27, 2023 Biocure Technology Corp. (CSE:CURE) (OTCQB: BICTF) ("CURE" or the "Company") BiocurePharm, Korea ("BPK"), a wholly owned subsidiary of Biocure Technology Inc. ("CURE") reported that it has closed its non-brokered private placement through its Korean Subsidiary BiocurePharm, Korea ("BPK"), BPK has issued 96,404 shares at $11.45 CAD per share for gross proceeds of $1,103,749 (Press release, Biocure Technology, FEB 27, 2019, View Source,-korea-bpk-announces-closing-of-private-placement [SID1234628756]). After the issuance of new BPK shares, CURE holds now 97.32% interest in BPK.

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The net proceeds from the non-brokered private placement are intended to be used for general working capital and research and development.

On February 27, 2019 Silverback Therapeutics, Inc., a biotechnology company developing a pipeline of systemically delivered, locally active therapies, will present preclinical data on its lead clinical candidate, SBT6050, at the 110th meeting of the American Association of Cancer Research (AACR) (Free AACR Whitepaper), taking place March 29 to April 3 in Atlanta (Press release, Silverback Therapeutics, FEB 27, 2019, View Source [SID1234550490]). SBT6050 is a novel immune-modulatory conjugate that utilizes cell surface expression of HER2 to localize activation of TLR8 (toll-like receptor 8) for the treatment of HER2-expressing tumors.

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The presentation, titled "A Systemically Administered, Conditionally Active TLR8 Agonist for the Treatment of HER2-Expressing Tumors," is the first data to be presented on Silverback’s technology. SBT6050 is comprised of a TLR8 agonist conjugated to a HER2-directed monoclonal antibody, designed to activate myeloid cells only in the presence of HER2-expressing tumor cells with moderate-to-high expression levels. In mouse HER2-expressing tumor models, a surrogate molecule of SBT6050 drives activation of both innate and adaptive immune responses, resulting in single agent efficacy. Due to localized activation of myeloid cells, TLR conjugates do not cause an overproduction of peripheral cytokines in preclinical models. Silverback plans to advance SBT6050 into the clinic in 2020.

"Tumors resistant to checkpoint inhibition lack T cells but are replete with myeloid cells. TLR8 activation of tumor-resident myeloid cells results in potent anti-tumor immune responses, but effective delivery has been the key challenge," said Valerie Odegard, Ph.D., Silverback’s chief scientific officer. "Our preclinical studies demonstrate that systemic delivery of a TLR agonist with tumor-localized activity dramatically rewires the tumor microenvironment, resulting in durable, single agent efficacy in tumors refractory to checkpoint blockade."

"These are the first data we are disclosing publicly that demonstrate the ability of Silverback’s technology to localize delivery of potent therapies to specific sites in the body," said Peter Thompson, M.D., Silverback’s co-founder, chief executive officer and chairman. "Our data show the successful, specific delivery of a TLR agonist to HER2-expressing tumor cells upon systemic administration—thereby addressing a fundamental challenge previously limiting use of innate immune agonists to topical and intratumoral administration, largely due to toxicity arising from widespread myeloid cell activation with systemic use of these agents. With this validating data in hand, we are applying our technology to a broad range of targets and diseases."

Presentation details are as follows:

Presentation Type: Poster (Abstract 3830)
Title: A Systemically Administered, Conditionally Active TLR8 Agonist for the Treatment of HER2-Expressing Tumors
Presenter: Kara Moyes, Ph.D.
Session Date and Time: Tuesday, April 2, 2019 8:00 AM – 12:00 PM
Location: Georgia World Congress Center, Exhibit Hall B

About Silverback’s Platform Technology
Silverback’s proprietary technology and integrated R&D approach enables the design of product candidates that can be administered systemically, but that act only at the sites of disease. The approach is designed to spare healthy tissues from unwanted side effects, while modifying disease processes in a potent and targeted manner. Silverback is directing the platform to modulate fundamental pathways underlying serious or life-threatening diseases, which traditional antibody and small molecule-based approaches have not been able to successfully target with systemic dosing due to inadequate activity and/or unacceptable toxicities. Silverback has filed over 15 patent families covering the platform and related product candidates.

On February 27, 2019 Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive biomarkers, reported that data from its Phase 1/2 ICONIC trial, an open label trial evaluating JTX-2011 monotherapy and in combination with nivolumab, will be the subject of two poster presentations at the upcoming 2019 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting at the Georgia World Congress Center in Atlanta, GA on March 31- April 3, 2019 (Press release, Jounce Therapeutics, FEB 27, 2019, View Source [SID1234535390]). In addition, Jounce Therapeutics will present a poster that will describe the preclinical evaluation of JTX-8064, a highly specific monoclonal antibody that aims to reprogram human macrophages from an immune suppressive to immune active state by inhibiting the cell surface receptor LILRB2.

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"The JTX-2011 clinical data being presented show that ICONIC patients with emergence of ICOS hi CD4 T cells in the peripheral blood have improved progression free and overall survival. This finding further validates the role of this ICOS pharmacodynamic biomarker in directing the next stage of the clinical development strategy for JTX-2011. Establishing the importance of this biomarker and its association with improved survival leads us to two distinct paths; first, combination with other agents that are known to induce ICOS hi CD4 T cells which JTX-2011 may then further stimulate; and second, using candidate predictive biomarkers identified through analysis of baseline samples of patients with and without emergence of these cells," said Elizabeth Trehu, M.D., chief medical officer of Jounce Therapeutics. "In addition to the data from our JTX-2011 program, we will also highlight JTX-8064 and the preclinical evaluation of this novel product candidate and its role in reprogramming tumor-associated macrophages within the tumor microenvironment."

JTX-2011 Posters Details:
Improved progression-free and overall survival (PFS/OS) in patients (pts) with emergence of JTX-2011 associated biomarker (ICOS high CD4 T cells) on the ICONIC trial
Session Title: Phase II-III Clinical Trials: Part 2
Location: Exhibit Hall B, Poster Section 16
Date and Time: Tuesday April 2, 20191:00 PM – 5:00 PM ET
Poster Board Number: 3; Permanent Abstract Number: CT189

Genetic and molecular profiling of ICOS hi CD4 T cells demonstrates clonal expansion of TH1 effector cells following JTX-2011 treatment in subjects with solid tumors
Session Title: Biomarkers and Immune Monitoring
Location: Exhibit Hall B, Poster Section 22
Date and Time: Tuesday April 2, 20191:00 PM – 5:00 PM ET
Poster Board Number: 16; Permanent Abstract Number: 4053

JTX-8064 Poster Details:
Preclinical evaluation of JTX-8064, an anti-LILRB2 antagonist antibody, for reprogramming tumor-associated macrophages
Session Title: Tumor Immune Microenvironment
Location: Exhibit Hall B, Poster Section 25
Date and Time: Wednesday April 3, 20198:00 AM – 12:00 PM ET
Poster Board Number: 1; Permanent Abstract Number: 5007

The posters will be available at the start of each session on the "Our Approach" section of the Jounce Therapeutics website at www.jouncetx.com.

Jounce Therapeutics to Host Event and Webcast
Jounce Therapeutics will host an investor and analyst event beginning at 6:30 p.m. ET and live webcast beginning at 7:00 p.m. ET, on Tuesday, April 2, 2019. To access the live webcast, please visit the "Events & Presentations" page in the Investors and Media section of the company’s website at www.jouncetx.com. The webcast will be archived and made available for replay on the company’s website approximately two hours after the call and will be available for 30 days thereafter.

About JTX-2011
Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS, a protein on the surface of certain T cells. The company is developing JTX-2011 to treat solid tumors as a single agent and in combination with other therapies.

About JTX-8064
JTX-8064 is an anti-Leukocyte Immunoglobulin Like Receptor B2 (LILRB2) antibody and is the first candidate to emerge from Jounce’s Translational Science Platform efforts that focuses on tumor-associated macrophages. JTX-8064 is currently in IND-enabling activities and Jounce anticipates filing an IND and initiating a Phase 1 clinical trial for JTX-8064 in 2019.

On February 27, 2019 Calithera Biosciences, Inc. (Nasdaq: CALA), a clinical stage biotechnology company focused on discovering and developing novel small molecule drugs for the treatment of cancer and other life-threatening diseases, reported that preclinical data highlighting the potential of CB-708, the company’s orally bioavailable CD73 inhibitor will be presented in a poster session at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2019, taking place March 29 to April 3, 2019 in Atlanta, Georgia (Press release, Calithera Biosciences, FEB 27, 2019, View Source [SID1234535228]).

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Details for the presentation are as follows:

Title: Reversal of adenosine-mediated immune suppression by CB-708, an orally bioavailable and potent small molecule inhibitor of CD73 Presenter:Clarissa Lee, Calithera Biosciences Session

Title: Novel Immunomodulatory Agents 2, Abstract #4134

Session Date and Time: Tuesday April 2, 20191:00 p.m. ET-5:00 p.m. ET

Location: Georgia World Congress Center, Exhibit Hall B, Poster Section 25, Board 8

Additional meeting information can be found at the AACR (Free AACR Whitepaper) website www.aacr.org.

The poster presentation will be available at www.calithera.com in the Publications Section.

CD73 is an enzyme in the tumor microenvironment that produces adenosine, a powerful inhibitor of immune function in tumors. CD73 is expressed across a wide range of tumor types and tumor infiltrating leukocytes. Expression of CD73 often correlates with poor prognosis in patients with cancer. Blockade of adenosine production by CD73 inhibition is expected to reverse immunosuppression in the tumor microenvironment and enhance the immune system’s ability to fight the cancer. CB-708 is an orally bioavailable small molecule inhibitor of CD73.

On February 27, 2019 Aprea Therapeutics, a clinical-stage biotechnology company developing novel anticancer therapies targeting the p53 tumor suppressor protein, reported that funds managed by Janus Henderson Investors joined its Series C financing as a new investor, raising the total amount of the financing to EUR 55 million (Press release, Aprea, FEB 27, 2019, View Source [SID1234535073]). Janus Henderson Investors joins the financing round closed in November, 2018 and led by Redmile Group, with participation by Rock Springs Capital and existing investors: 5AM Ventures, Versant Ventures, HealthCap, Sectoral Asset Management and Karolinska Development AB (Nasdaq Stockholm: KDEV).

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"The addition of Janus to our investor group further broadens our US investor base and better positions the company to both advance its clinical strategy in hematological malignancies and take advantage of future strategic opportunities," said Christian S. Schade, President and Chief Executive Officer of Aprea Therapeutics.

Proceeds from the financing will be used to advance the clinical development of APR-246, a first-in-class anticancer agent that reactivates mutated p53 tumor suppressor protein. Aprea has commenced a Phase 3 clinical study in myelodysplastic syndromes (MDS) and has completed enrollment in a Phase Ib/II clinical trial in p53 mutated high-risk myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia (AML) with APR-246 and azacitidine. Additional studies in MDS and AML are underway and in planning with other approved agents.

About Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) represents a spectrum of hematopoietic stem cell malignancies in which bone marrow fails to produce sufficient numbers of healthy blood cells. Approximately 30-40% of MDS patients progress to acute myeloid leukemia (AML) and mutation of the p53 tumor suppressor protein is thought to contribute to disease progression. Mutations in p53 are found in up to 20% of MDS and AML patients and are associated with poor overall prognosis.

About p53 and APR-246

The p53 tumor suppressor gene is the most frequently mutated gene in human cancer, occurring in approximately 50% of all human tumors. These mutations are often associated with resistance to anti-cancer drugs and poor overall survival, representing a major unmet medical need in the treatment of cancer.

APR-246 has been shown to reactivate mutant and inactivated p53 protein – by restoring wild-type p53 conformation and function – and thereby induce programmed cell death in human cancer cells. APR-246 has demonstrated pre-clinical anti-tumor activity in a wide variety of solid and hematological (blood) tumors, including MDS, AML, and ovarian cancer, among others. Additionally, strong synergy has been seen with both traditional anti-cancer agents, such as chemotherapy, as well as newer mechanism-based anti-cancer drugs and immuno-oncology checkpoint inhibitors. In addition to pre-clinical testing, a Phase I/II clinical program with APR-246 has been completed, demonstrating a favorable safety profile and both biological and confirmed clinical responses in hematological malignancies and solid tumors with mutations in the TP53 gene.