On January 11, 2018 NantKwest presented JP Morgan Healthcare Conference Presentation 2018 (Press release, NantKwest, JAN 11, 2018, http://ir.nantkwest.com/phoenix.zhtml?c=254059&p=RssLanding&cat=news&id=2326280 [SID1234523063]).

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On January 11, 2018 Ziopharm presented Presentation of the Company (Press release, Ziopharm, JAN 11, 2018, View Source [SID1234523066]).

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On January 10, 2018 LIDDS reported that it has successfully completed another preclinical study in mice assessing the feasibility of using the NanoZolid drug delivery technology for intratumoral immunotherapy (Press release, Lidds, JAN 10, 2018, https://www.globenewswire.com/news-release/2018/01/10/1286736/0/en/LIDDS-NanoZolid-with-immune-stimulating-agent-confirms-efficacy-in-an-additional-cancer-model.html [SID1234555920]). Clear anti-tumor effects have been observed in another cancer model in mice where significant decreases in tumor growth was demonstrated.

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LIDDS has several projects ongoing that focus on assessing the feasibility of using the NanoZolid-technology for local or intratumoral immunotherapy. These studies aim at a local intratumoral delivery of an immune-stimulatory agent.

The confirmed anti-tumor effect of an immune-stimulating agent formulated using the NanoZolid-technology in two independent cancer models in mice, will trigger the initiation of follow-on studies. The possibility that local immune-stimulation using the NanoZolid-technology will increase the effects of systemic immunotherapy will be investigated. Results are expected during the next four months.

A locally delivered immunotherapy has the potential to act either as a monotherapy or in combination with systemic immunotherapies e.g. checkpoint inhibitors. Successful combination treatments could significantly increase the response rates and efficacy rates of current immunotherapies. As immuno-oncology is the fastest growing area in oncology, reaching a market size over 100 billion USD by 2022, these results should be of great interest to pharmaceutical companies seeking new combination modalities to increase the response rate and efficacy of their immunotherapy drugs.

A recent review article in the highly ranked journal Annals of Oncology highlights the unique opportunity of intratumoral treatments to increase the efficacy of immunotherapy while reducing the potential side-effects, View Source

Immunotherapy for the treatment of cancer aims to activate and utilize the body’s own immune system to recognize and attack tumors and cancer cells and is today the most promising area of cancer research.

Researchers have shown that ritanserin is a novel DGK-alpha inhibitor, with activity against glioblastoma (GBM) in vitro and in vivo. They have shown that it is synergistic with temozolomide chemotherapy and radiation against GBM cells. Furthermore, ritanserin has preferential cytotoxicity against mesenchymal GBM cells, a particularly treatment-resistant subset lacking any selective and effective therapies at this time.

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On January 10, 2018 Immix Biopharma, Inc., reported that it has received Human Research Ethics Committee (IRB) approval to begin a Phase 1/2a Open-Label, Dose-Escalation/Dose-Expansion Safety, Tolerability and Pharmacokinetic Study of IMX-110 in Participants with Advanced Solid Tumors ( View Source ) (Press release, Immix Biopharma, JAN 10, 2018, View Source [SID1234523373]).

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In preclinical studies, Immix flagship platform candidate Imx-110 demonstrated efficacy against pancreatic, gliobastoma, triple negative breast, colorectal, multiple myeloma and ovarian cancer models. Preclinical data from a syngeneic KPC pancreatic cancer model demonstrated not only a marked reduction in tumor size, but also a wholesale rearrangement of the immune system and tumor microenvironment with near complete disappearance of regulatory T and endothelial cells from tumor foci with simultaneous tumor infiltration by CD8 lymphocytes post-treatment.

This cross-tumor efficacy in diverse models is a testament to the far-reaching potential of the approach employed by Immix. "By creating a combination therapy which attacks the root drivers of cancer’s evolutionary adaptability and resistance to any therapy, we have the chance to really change the paradigm of chasing tumor adaptations and provide meaningful benefit to cancer patients," shares CEO and co-founder Ilya Rachman, MD, PhD, MBA.

Imx-110 is a first-in-class combination therapy designed to inhibit cancer resistance and evolvability, while inducing apoptosis. Imx-110 contains NF-kB/Stat3/pan-tyrosine kinase inhibitor curcumin combined with a small amount of doxorubicin, encased in a nano-sized delivery system for optimal tumor penetration. The nanoparticle is tunable in that it can be bound to various targeting moieties – delivering even more payload to tumors or other cell populations of interest, if needed.

The study’s Principal Investigator Professor de Souza shared, "We are excited to be able to partner with Immix in conducting this first-in-human study with a promising novel nanoparticle. I look forward to seeing what it can do in cancers that are traditionally difficult to treat." To stay updated on the latest clinical results or for queries, please contact: