On November 29, 2024 – Helix BioPharma Corp. (TSX: "HBP", OTC PINK: "HBPCD", FRANKFURT: "HBP0") ("Helix" or the "Company"), a clinical-stage biopharmaceutical company developing novel and unique therapies in the field of immune-oncology, based on its proprietary technological CEACAM6 platform, DOS47, reported that it has entered into an asset purchase agreement dated November 28, 2024 (the "Agreement"), with Laevoroc Immunology AG ("Laevoroc Immunology"), a privately-held, Swiss immune-oncology company (Press release, Helix BioPharma, NOV 29, 2024, View Source [SID1234648700]).

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As a result of the Transaction, Helix will acquire the intellectual property, inventory, assigned agreements and rights to LR 09, an oral immune checkpoint inhibitor in preclinical development for patients relapsing with leukemia after the intensive journey of allogeneic stem cell transplantation (SCT). LR 09 (Ulodesine hemiglutarate) is a novel, patented chemical entity discovered to be a metabolic immune checkpoint inhibitor and granted Orphan Drug Designation by the US Food and Drug Administration (FDA) in 2022.

Pursuant to the Agreement, Helix shall acquire substantially all of the assets and certain liabilities of Laevoroc Immunology in consideration for the issuance of 16.5% of the Company’s issued and outstanding shares on the closing date of the transaction (the "Transaction"). If the Transaction were to close today, Helix would be required to issue 8,088,553 common shares based on the Company’s 49,021,536 shares currently issued and outstanding. The Company anticipates that the Transaction will close on or around January 30, 2025 and all shares issuable in connection with the Transaction will be subject to a hold period of four months and one day from the date of issuance. The Transaction is subject to the approval of the Toronto Stock Exchange and certain closing conditions of transactions of a similar nature.

The Agreement follows the signing of a non-binding letter of intent announced in a press release published by Helix and dated 13 November, 2024.

Jacek Antas, CEO of Helix Biopharma, said: "We are pleased to reach this agreement with Laevoroc Immunology, which marks an important step in our asset acquisition process and, ultimately, the growth of our immune-oncology pipeline with a therapeutic candidate targeting critical unmet needs in leukaemia treatment. We are confident that this strategic addition will contribute long-term value and growth for our shareholders."

On November 29, 2024 Amgen (NASDAQ:AMGN) reported that it will present at the 7th Annual Evercore HealthCONx Conference at 10:00 a.m. ET on Wednesday, Dec. 4, 2024. Peter Griffith, executive vice president and chief financial officer at Amgen, Jay Bradner, executive vice president of Research and Development and chief scientific officer at Amgen, and Susan Sweeney, executive vice president of Obesity and Related Conditions at Amgen, will participate in a fireside chat at the conference (Press release, Amgen, NOV 29, 2024, https://investors.amgen.com/news-releases/news-release-details/amgen-present-7th-annual-evercore-healthconx-conference [SID1234648699]). The webcast will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public.

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The webcast, as with other selected presentations regarding developments in Amgen’s business given by management at certain investor and medical conferences, can be found on Amgen’s website, www.amgen.com, under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen’s Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event.

On November 28, 2024 Allink Biotherapeutics, a clinical-stage biotechnology company pioneering next-generation bispecific antibody and antibody-drug conjugate (ADC) therapeutics, reported the successful completion of a $42 million Series A financing (Press release, Shanghai Allink Biotherapeutics, NOV 28, 2024, View Source [SID1234648781]). The financing round was led by Lanchi Ventures, a preeminent global early-stage technology investor known for backing breakthrough innovations, with participation from an elite syndicate of new investors including Yuanbio Venture Capital, Legend Capital and C&D Emerging Industry Equity Investment, alongside strong support from existing shareholders Gaorong Ventures and Med-Fine Capital.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"Since our company’s inception a little over a year ago, AllinkBio has rapidly advanced from lead asset PCC to clinical development stage," said Hui Feng, Ph.D., Founder and Chief Executive Officer of AllinkBio. "We are grateful for the continued support from existing shareholders and delighted to welcome new investors who recognize both our scientific excellence and capability of translating scientific findings into clinical applications. Their support enables us to accelerate the development of our diverse pipeline spanning multiple modalities including next-generation ADCs and bispecific antibodies targeting oncology and immunology diseases. Looking ahead, we are poised to achieve multiple pipeline milestones in the coming months as we pursue our long-term mission of bringing innovative therapeutics to patients with significant unmet medical needs."

"AllinkBio’s exceptional execution speed and quality in advancing its lead program from preclinical to clinical stage, led by Dr. Feng, one of the leading figures in China’s biopharmaceutical industry, demonstrates the company’s high competitiveness in the field," said Lanchi Ventures. "AllinkBio’s innovative approach to ADC development presents a compelling opportunity in the targeted oncology therapeutics space."

"Our continued investment in AllinkBio reflects our strong conviction in the company’s scientific excellence and execution capabilities," said Jiangtao Yu, Ph.D., Managing Director at Gaorong Ventures. "Since our initial investment, we have been impressed by the company’s rapid advancement in both platform development and pipeline progression. We are excited to strengthen our commitment through this Series A financing."

"We are delighted to have witnessed the fast and steady development of AllinkBio. Dr. Feng and his team’s dedicated work in progressing two highly promising ADC drug candidates into clinical stage within one and half years since company inception has been really impressive. We believe the company has great potential and will continuously support its endeavor in developing innovative drugs for patients in need globally." said Angel Round lead investor Vince Deng, Ph.D., Partner of Med-Fine Capital.
The Series A financing proceeds will be deployed to advance:
Global clinical development of lead candidates ALK201 and ALK202 through Phase 1 studies in Australia, the United States and China
Enrichment of current portfolio by developing multiple highly competitive new assets in oncology and immunology
Further development of the company’s proprietary bispecific antibody and ADC technology platform
Global footprint expansion to achieve world prominence
The successful completion of this round of financing marks a pivotal moment in AllinkBio’s growth trajectory. With the new financial resources in place, combined with the company’s efficient R&D capabilities, AllinkBio is well-positioned for expedited growth toward new heights on both its product and corporate development fronts.

On November 28, 2024 Allink Biotherapeutics, a clinical-stage biotechnology company pioneering next-generation bispecific antibody and antibody-drug conjugate (ADC) therapeutics, reported the successful completion of a $42 million Series A financing (Press release, Shanghai Allink Biotherapeutics, NOV 28, 2024, View Source [SID1234648697]). The financing round was led by Lanchi Ventures, a preeminent global early-stage technology investor known for backing breakthrough innovations, with participation from an elite syndicate of new investors including Yuanbio Venture Capital, Legend Capital and C&D Emerging Industry Equity Investment, alongside strong support from existing shareholders Gaorong Ventures and Med-Fine Capital.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"Since our company’s inception a little over a year ago, AllinkBio has rapidly advanced from lead asset PCC to clinical development stage," said Hui Feng, Ph.D., Founder and Chief Executive Officer of AllinkBio. "We are grateful for the continued support from existing shareholders and delighted to welcome new investors who recognize both our scientific excellence and capability of translating scientific findings into clinical applications. Their support enables us to accelerate the development of our diverse pipeline spanning multiple modalities including next-generation ADCs and bispecific antibodies targeting oncology and immunology diseases. Looking ahead, we are poised to achieve multiple pipeline milestones in the coming months as we pursue our long-term mission of bringing innovative therapeutics to patients with significant unmet medical needs."

"AllinkBio’s exceptional execution speed and quality in advancing its lead program from preclinical to clinical stage, led by Dr. Feng, one of the leading figures in China’s biopharmaceutical industry, demonstrates the company’s high competitiveness in the field," said Lanchi Ventures. "AllinkBio’s innovative approach to ADC development presents a compelling opportunity in the targeted oncology therapeutics space."

"Our continued investment in AllinkBio reflects our strong conviction in the company’s scientific excellence and execution capabilities," said Jiangtao Yu, Ph.D., Managing Director at Gaorong Ventures. "Since our initial investment, we have been impressed by the company’s rapid advancement in both platform development and pipeline progression. We are excited to strengthen our commitment through this Series A financing."

"We are delighted to have witnessed the fast and steady development of AllinkBio. Dr. Feng and his team’s dedicated work in progressing two highly promising ADC drug candidates into clinical stage within one and half years since company inception has been really impressive. We believe the company has great potential and will continuously support its endeavor in developing innovative drugs for patients in need globally." said Angel Round lead investor Vince Deng, Ph.D., Partner of Med-Fine Capital.

The Series A financing proceeds will be deployed to advance:

Global clinical development of lead candidates ALK201 and ALK202 through Phase 1 studies in Australia, the United States and China
Enrichment of current portfolio by developing multiple highly competitive new assets in oncology and immunology
Further development of the company’s proprietary bispecific antibody and ADC technology platform
Global footprint expansion to achieve world prominence
The successful completion of this round of financing marks a pivotal moment in AllinkBio’s growth trajectory. With the new financial resources in place, combined with the company’s efficient R&D capabilities, AllinkBio is well-positioned for expedited growth toward new heights on both its product and corporate development fronts.

On November 28, 2024 Akeso, Inc. (9926.HK) ("Akeso" or the "Company") reported its participation in the upcoming 7th Annual Evercore HealthCONx Conference and Citi 2024 Global Healthcare Conference, both taking place in Miami (Press release, Akeso Biopharma, NOV 28, 2024, https://www.prnewswire.com/news-releases/akeso-to-present-at-citi-2024-global-healthcare-conference-and-the-7th-annual-evercore-healthconx-conference-302318502.html [SID1234648696]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Akeso will participate in a fireside chat at the 7th Annual Evercore HealthCONx Conference on Wednesday, December 4, 2024, at 8:45 AM ET. Akeso will also join a fireside chat at the Citi 2024 Global Healthcare Conference on Thursday, December 5, 2024, from 8:45 AM to 9:25 AM ET.

Live streams of Akeso’s presentations at the 7th Annual Evercore HealthCONx Conference will be available at:View Source