Entry Into a Material Definitive Agreement

On August 28, 2024, BioMarin Pharmaceutical Inc., a Delaware corporation (the "Company"), reported to have entered into a Credit Agreement (the "Credit Agreement") with Citibank, N.A., as Administrative Agent ("Citibank" or the "Administrative Agent"), and the Lenders party thereto (the "Lenders") (Filing, 8-K, BioMarin, AUG 28, 2024, View Source [SID1234646337]).

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The Credit Agreement provides for up to $600 million in revolving loans (the "Revolving Credit Facility"), none of which was drawn at closing. Subject to the satisfaction of certain conditions precedent, the Company will be entitled to draw funds at its discretion until the Revolving Credit Facility matures on August 28, 2029 (the "Maturity Date"), at which time all outstanding loans shall become due and payable and all outstanding letters of credit shall be cash collateralized. The Company expects to use the proceeds of the Revolving Credit Facility to finance ongoing working capital needs and for other general corporate purposes.

Loans under the Credit Agreement will bear interest at a floating rate per annum based on (i) in the case of US dollar denominated loans, either (x) the Secured Overnight Financing Rate (subject to a zero percent floor), plus a spread adjustment of 10 bps ("Term SOFR"), plus a margin ranging from 112.5 bps to 175 bps per annum, based upon the Company’s total net leverage ratio or (y) the Base Rate, which is the highest of (A) the Federal Funds Rate plus 50 bps, (B) Citibank’s "prime rate", or (C) Term SOFR plus 100 bps, plus a margin ranging from 12.5 bps to 75 bps per annum, based upon the Company’s total net leverage ratio; (ii) in the case of euro denominated loans, the Euro Interbank Offered Rate ("EURIBOR"), plus a margin ranging from 112.5 bps to 175 bps per annum, based upon the Company’s total net leverage ratio; and (iii) in the case of sterling denominated loans, the Sterling Over Night Indexed Average, plus a margin ranging from 112.5 bps to 175 bps per annum, based upon the Company’s total net leverage ratio. Unutilized commitments under the Credit Agreement will accrue an unused line fee ranging from 12.5 bps to 20 bps per annum, based upon the Company’s total net leverage ratio, to be paid quarterly in arrears.

The Company will have the right, but not the obligation, to prepay the Revolving Credit Facility in whole or in part and/or terminate the Revolving Credit Facility without premium or penalty on or prior to the Maturity Date.

The Credit Agreement includes customary representations, warranties and covenants, including, among other things, restrictions on the Company’s and certain of its subsidiaries’ ability to incur additional indebtedness, dispose of its assets, incur liens, make investments, and pay dividends or other distributions, in each case subject to specified exceptions. The Credit Agreement also contains customary indemnification obligations and customary events of default, including, but not limited to, failure to timely make payments when due under the Credit Agreement, failure to comply with any of the covenants under the Credit Agreement or any other loan document, the occurrence of certain insolvency or bankruptcy-related events, cross-default to certain other material indebtedness and the occurrence of a "change of control" (as defined in the Credit Agreement).

During the occurrence and continuance of an event of default by the Company under the Credit Agreement, the Lenders would be entitled to exercise their remedies thereunder, including termination of the commitment of each Lender to make loans and any obligation of the issuer of letters of credit under the Revolving Credit Facility to make credit extensions, and the right to accelerate any outstanding obligations under the Credit Agreement.

A copy of the Credit Agreement is filed as Exhibit 10.1 hereto.

PDX Pharma was granted a new EU patent

On August 28, 2024 PDX Pharma reported the company was granted a new EU patent (EP3270932) on August 21, 2024, covering the composition and method of use for our innovative Pdx-NP nanoparticle platform (Press release, PDX Pharmaceuticals, AUG 28, 2024, View Source [SID1234646305]). Developed as a polymer-coated mesoporous silica alternative to lipid-based particles, which tend to home to the liver, Pdx-NP is the core nanotechnology behind all of PDX Pharmaceuticals’ pipelines. These include the HER2-targeted therapy T-siHER2-NP, the radiation sensitizer PETTRA, the immunotherapeutics ARAC and AIRISE, the nano-cytokine CK-NP for cancer treatments, and the AIRISE-VAC vaccine platforms for infectious diseases. This patent strengthens our IP beyond the U.S. patent (US11207428) issued in December 2021, bolstering our commercialization efforts. Congratulations to the inventors from PDX Pharma and OHSU, including Drs. Wassana Yantasee, Worapol (Boom) Ngamcherdtrakul, Joe Gray, Jingga Morry, and David Castro.

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AN2 Therapeutics to Present at the H.C. Wainwright 26th Annual Global Investment Conference

On August 28, 2024 AN2 Therapeutics, Inc. (Nasdaq: ANTX), a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from its boron chemistry platform, reported that Eric Easom, Co-Founder, Chairman, President and CEO will present at the H.C. Wainwright 26th Annual Global Investment Conference (Press release, AN2 Therapeutics, AUG 28, 2024, View Source [SID1234646180]).

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Details of the event is as follows:

H.C. Wainwright 26th Annual Global Investment Conference

Eric Easom, Co-Founder, Chairman, President and CEO will provide a corporate overview on Tuesday, September 10 at 9:30am ET
A webcast of the presentation can be accessed on the Investors section of the AN2 Therapeutics website at www.an2therapeutics.com. An archived replay will be available for at least 30 days following the presentation.

Novocure to Participate in 2024 Wells Fargo Healthcare Conference

On August 28, 2024 Novocure (NASDAQ: NVCR) reported that management will participate in the 2024 Wells Fargo Healthcare Conference on Wednesday, September 4, 2024 (Press release, NovoCure, AUG 28, 2024, View Source [SID1234646179]). William Doyle, Novocure’s Executive Chairman, will take part in a fireside chat at 4:30 p.m. EST, as well as one-on-one meetings with investors throughout the event.

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A live audio webcast of this presentation can be accessed from the Investor Relations page of Novocure’s website, www.novocure.com/investor-relations, and will be available for replay for at least 14 days following the event.

Novocure’s corporate presentation is updated periodically, and the current presentation can be accessed from the Investor Relations page of Novocure’s website, www.novocure.com/investor-relations. Novocure has used, and intends to continue to use, its Investor Relations website as a means of disclosing material non-public information and for complying with its disclosure obligations under Regulation FD.

Natera to Participate in the Morgan Stanley 22nd Annual Global Healthcare Conference

On August 28, 2024 Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and genetic testing, reported that members of its leadership team will present at the Morgan Stanley 22nd Annual Global Healthcare Conference on Wednesday, Sept. 4 at 2:35 pm ET | 11:35 am PT in New York City (Press release, Natera, AUG 28, 2024, View Source [SID1234646178]).

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A live webcast and audio archive of the event may be accessed through the investor relations section of the Natera website at investor.natera.com. A replay of the event will be available shortly following the conference.