On August 28, 2023 FogPharma, a biopharmaceutical company committed to transforming the lives of patients through a new precision medicine approach widely applicable to important and challenging intracellular targets, reported that Fierce Biotech has named it as one of 2023’s "Fierce 15" biotechnology companies (Press release, FogPharma, AUG 28, 2023, View Source [SID1234634718]). The annual special report features the most innovative and promising early-stage biotechnology companies in the industry.

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"It is an honor to be among the elite Fierce 15 class of 2023," said Mathai Mammen, M.D., Ph.D. "I am proud of the FogPharma team and the important work that this team has done on behalf of patients with devastating illness using a unique and powerful drug modality capable of modulating important intracellular targets. We are currently advancing our first program, betacatenin inhibitor FOG-001 for the potential treatment of a wide range of cancers, including colorectal cancer."

"For the past 21 years, we have assessed hundreds of early-stage companies for inclusion in the ‘Fierce 15’ special report. To curate this list, we consider a diverse range of factors, including the robustness of their technology, partnerships, venture support and their competitive positioning within the market," said Ayla Ellison, Editor-in-Chief, Fierce Life Sciences and Healthcare. "Our special report celebrates innovation and creativity in the face of intense competition."

On August 28, 2023 Proxygen, a leader in the discovery and development of molecular glue degraders, reported that Fierce Biotech has named it as one of 2023’s "Fierce 15" biotechnology companies (Press release, Proxygen, AUG 28, 2023, View Source [SID1234634717]). The annual special report features the most innovative and promising early-stage biotechnology companies in the industry.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"It is an incredible honor to be recognized as one of the Fierce 15 biotech companies for 2023," said Bernd Boidol, Ph.D., chief executive officer of Proxygen. "We have seen Proxygen going through an outstandingly successful development over the last three years. Our team of world-class scientists combined with a unique platform has enabled significant progress for both our internal programs and strategic collaborations. We are excited to see these efforts coming to fruition."

Molecular glue degraders redirect the cell’s own quality control machinery towards disease-causing proteins, inducing their selective and complete elimination. Due to the ability of molecular glue degraders to modulate protein classes unamenable to traditional drug discovery approaches, these molecules hold the promise of unlocking a large proportion of the undruggable target space and delivering innovative therapies for diseases with high medical need. However, the lack of scalable discovery strategies has so far hindered the full exploitation of the clinical potential of molecular glue degraders.

By streamlining and fully integrating cutting-edge genomic, proteomic, and biochemical technologies, Proxygen has successfully developed a highly versatile glue degrader discovery engine. The unbiased screening approach enables the specific identification of molecular glue degraders against difficult-to-drug or completely undruggable targets at large scale. The company has generated expansive knowledge and data in the discovery and chemical optimization of degrader molecules, positioning it as a pioneer in this novel modality.

"For the past 21 years, we have assessed hundreds of early-stage companies for inclusion in the ‘Fierce 15’ special report. To curate this list, we consider a diverse range of factors, including the robustness of their technology, partnerships, venture support and their competitive positioning within the market," said Ayla Ellison, Editor-in-Chief, Fierce Life Sciences and Healthcare. "Our special report celebrates innovation and creativity in the face of intense competition."

On August 28, 2023 Perspective Therapeutics, Inc. ("Perspective" or "the Company") (NYSE AMERICAN: CATX), reported that it will present new clinical and preclinical data for 212Pb-VMT-α-NET, a Targeted Alpha-Particle Therapy, at the upcoming 36th Annual Congress of the European Association of Nuclear Medicine (EANM) (Press release, Perspective Therapeutics, AUG 28, 2023, View Source [SID1234634716]). The conference is being held in Vienna, Austria, from September 9-13, 2023.

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"Our team at Perspective Therapeutics continues to work diligently to advance much needed targeted alpha therapy using 212Pb," said Thijs Spoor, Chief Executive Officer at Perspective Therapeutics. "We are particularly excited about the early clinical results from 212Pb-VMT-α-NET in patients suffering from different types of difficult-to-treat neuroendocrine tumors. These results support our belief that targeted alpha therapies have the potential to revolutionize our approach to eliminating cancers and intractable tumors."

"We are excited to have early results presented by Dr. Dharmender Malik of Fortis Memorial research institute on the safety and efficacy of 212Pb-VMT-α-NET especially in patients with somatostatin receptor positive, metastatic neuroendocrine and medullary thyroid tumors," said Markus Puhlmann, MD, MBA, Chief Medical Officer at Perspective Therapeutics. "Additionally, we will present data from our metastatic mouse model of neuroblastoma exploring the efficacy of 203/212Pb-VMT-α-NET for image-guided treatment in this metastatic neuroblastoma tumor model."

Details about these presentations can be found below and on the EANM website (eanm23.eanm.org). Additionally, copies of the abstracts can be found in the EANM ’23 Abstract Book on the EANM website.

Presentation One:

This presentation will discuss early clinical results from the study of 212Pb-VMT-α-NET in ten patients with somatostatin receptor (SSTR)-expressing progressive neuroendocrine tumors and metastatic medullary thyroid carcinomas. 212Pb-VMT-α-NET demonstrated an encouraging safety profile and treatment resulted in partial responses in a number of patients.

Title: Early results of 212Pb-VMT-α-NET Targeted Alpha Therapy in Metastatic Gastro-entero-pancreatic Neuroendocrine Tumors: First in Human Clinical Experience on Safety and Efficacy
Session: Theranostics Track – What’s New in Endocrine Tumors
Abstract Number: OP-673
Presenter: D. Malik, Consultant Nuclear Medicine and PET-CT, MBBS, DNB, FANMB & RSO-II at Fortis Memorial research institute (FMRI), Gurugram, India at Fortis Healthcare Pvt.
Details: Tuesday, September 12, 2023, 9:45 a.m. CEST
Location: Hall G1

Presentation Two:

This presentation will discuss the effective tumor control of fractionated doses of [212Pb]VMT-α-NET demonstrated in a mouse model of high-risk metastatic neuroblastoma. The data showed that fractionated doses of [212Pb]VMT-α-NET provided greater benefit than single dose administration of [212Pb]VMT-α-NET.

Title: Preclinical Evaluation of [212Pb]VMT-α-NET Targeted Alpha Therapy for High-Risk Metastatic Neuroblastoma
Session: M2M Track: Radioligand Therapy – New and Old Targets
Abstract Number: OP-144
Presenter: D. Liu, Principal Research Scientist, Perspective Therapeutics, Inc.
Details: Session 504, Sunday, September 10, 2023, 3.00 p.m. CEST
Location: Hall E2

On August 28, 2023 Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical-stage biopharmaceutical company developing disruptive therapeutics for the treatment of patients with urgent unmet medical needs, reported that management will be presenting virtually at the H.C. Wainwright 25th Annual Global Investment Conference (Press release, Panbela Therapeutics, AUG 28, 2023, https://panbela.com/press-release/panbela-to-present-at-h-c-wainwright-25th-annual-global-investment-conference/?utm_source=rss&utm_medium=rss&utm_campaign=panbela-to-present-at-h-c-wainwright-25th-annual-global-investment-conference [SID1234634715]).

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Interested parties may access the presentation beginning on September 11 at 7:00 A.M. (ET) via View Source Management will also be available for virtual one-on-one meetings. For additional information about the conference, visit View Source

On August 28, 2023 ImmunoGen, Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that it has entered into an exclusive collaboration with Takeda Pharmaceutical Company Limited (TSE: 4502/NYSE: TAK) to develop and commercialize ELAHERE (mirvetuximab soravtansine-gynx) in Japan (Press release, ImmunoGen, AUG 28, 2023, View Source [SID1234634714]).

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"As a leader in the development and commercialization of novel products in oncology for more than two decades and with a deep heritage and presence in Japan, Takeda is the ideal partner to help us deliver ELAHERE to eligible patients in this important market," said Mark Enyedy, ImmunoGen’s President and Chief Executive Officer. "Building upon our strong commercial launch in the US, this partnership reinforces the continued excitement around ELAHERE’s practice-changing potential and our commitment to bringing this biomarker-directed ADC to patients globally."

Under the terms of the collaboration and license agreement, ImmunoGen will receive a one-time, upfront payment and an additional payment upon conversion of US Food and Drug Administration (FDA) accelerated approval of ELAHERE in platinum-resistant ovarian cancer (PROC) to full approval. The Company is eligible to receive additional payments if Takeda achieves prespecified regulatory and commercial milestones, as well as double-digit royalties on future net sales of ELAHERE in Japan. Per the agreement, ImmunoGen has retained exclusive production rights and will supply product for development and commercial use in Japan. In exchange, Takeda will receive an exclusive license to develop and commercialize ELAHERE in Japan and is responsible for all regulatory filings and obligations.

"We are pleased to bring ELAHERE to Japan, where there is a significant unmet need for patients with ovarian cancer, particularly for those whose disease has become resistant to platinum-based treatments," said Teresa Bitetti, President of the Global Oncology Business Unit at Takeda. "The data from the Phase 3 MIRASOL study demonstrate the potential for ELAHERE to become the new standard of care for this devastating disease, and we are confident this collaboration with ImmunoGen will bring significant value to patients in Japan. This investment is reflective of Takeda’s commitment to partnering with organizations that share our passion for developing new medicines for cancers with limited or ineffective treatment options and brings us one step closer to achieving our aspiration to cure cancer."