Entry Into a Material Definitive Agreement

On November 1, 2023, Apellis Pharmaceuticals, Inc., a Delaware corporation (the "Company"), reported to have entered into a Sales Agreement (the "Agreement") with Cowen and Company, LLC, as agent ("Cowen"), pursuant to which the Company may offer and sell shares of its common stock, $0.0001 par value per share (the "Shares"), from time to time through Cowen (the "Offering") (Filing, 8-K, Apellis Pharmaceuticals, NOV 1, 2023, View Source [SID1234636623]). The Company has also filed a prospectus supplement with the Securities and Exchange Commission (the "SEC") in connection with the Offering (the "Prospectus Supplement") under the Company’s existing automatic shelf Registration Statement on Form S-3 (File No. 333-269899), which became effective on February 22, 2023 (the "Registration Statement"). Pursuant to the Prospectus Supplement, the Company may offer and sell Shares having an aggregate offering price of up to $300.0 million.

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Upon delivery of a placement notice and subject to the terms and conditions of the Agreement, Cowen may sell the Shares at market prices by any method deemed to be an "at the market offering" as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended (the "Securities Act"), including sales made directly on or through The Nasdaq Global Select Market ("Nasdaq"), the existing trading market for the Company’s common stock.

The Company or Cowen may suspend or terminate the offering of Shares upon notice to the other party, subject to certain conditions. Cowen will act as sales agent on a commercially reasonable efforts basis consistent with its normal trading and sales practices and applicable state and federal law, rules and regulations and the rules of Nasdaq.

The Company has agreed to pay Cowen commissions for its services of acting as agent of up to 3.0% of the gross proceeds from the sale of the Shares pursuant to the Agreement. The Company has also agreed to provide Cowen with customary indemnification and contribution rights.

A copy of the Agreement is attached as Exhibit 1.1 hereto and is incorporated herein by reference. The foregoing description of the material terms of the Agreement is qualified in its entirety by reference to such exhibit.

Wilmer Cutler Pickering Hale and Dorr LLP, counsel to the Company, has issued a legal opinion relating to the Shares. A copy of such legal opinion, including the consent included therein, is attached as Exhibit 5.1 hereto.

The Shares will be sold pursuant to the Registration Statement, and offerings of the Shares will be made only by means of the Prospectus Supplement. This Current Report on Form 8-K shall not constitute an offer to sell or solicitation of an offer to buy the Shares, nor shall there be any sale of the Shares in any state in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities law of such state or jurisdiction.

Anaveon announces presentation of ANV600 preclinical data supporting combination therapy with therapeutic PD-1 inhibitors

On November 1, 2023 Anaveon, a clinical stage, immuno-oncology company, reported that it will present a poster on ANV600 at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) being held from Friday, November 3, 2023, to Sunday, November 5, 2023, in San Diego, California (Press release, Anaveon, NOV 1, 2023, View Source [SID1234636622]).

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Targeting of stimulatory cytokines to PD-1 expressing tumor infiltrating lymphocytes (TILs) is a promising approach to reinvigorate antitumor immune responses. Currently, PD-1 checkpoint inhibitors (CPIs) have been established as the standard of care for many cancer indications. ANV600 combines a unique non-blocking PD-1 targeting approach with an IL-2Rβ/γ selective agonistic principle. This is a first example of a PD-1 targeted cytokine agonist which enables therapeutic combination of existing PD-1 inhibitors with novel PD-1 directed stimulatory cytokines.

"ANV600 is a powerful, new, targeted bispecific capable of proliferating tumor specific TILs" said Christoph Huber, Chief Scientific Officer of Anaveon. "We have designed the molecule to be compatible with anti-PD-1 antibodies to allow for optimal therapeutic combination of these agents."

The abstract is available on the SITC (Free SITC Whitepaper) website, and the accompanying poster will be on display on the Anaveon website on November 4, 10:00 am PDT.

Details of the poster presentation:

November 4, 9:00 am – 8:30 pm PDT, Poster #820

Title: ANV600 is a novel PD-1 targeted IL-2Rβ/γ agonist that is combinable with therapeutic PD-1 inhibitors

Authors: P. Murer, U. Salazar, N. Egli, L. Petersen, P. Neubert, Ch. Stocker, A. Rau, K. Richter, A. Katopodis and Ch. Huber

Anaveon is developing selective cytokine receptor agonists with the potential to therapeutically enhance a patient’s immune system to respond to tumors. ANV419, currently in Ph II studies in multiple cancer indications, is designed to preferentially signal through the IL-2 beta/gamma receptor resulting in strong proliferation of effector cells in patients. The follow-on compound, ANV600, targets the selective IL-2 receptor moiety to intratumoral effector cells and may have therapeutic benefit in less immunogenic tumors. These novel types of therapeutics, if approved, could potentially have a wide utility in oncology, including in combination with checkpoint inhibitors, cell therapies, vaccines, and radiotherapy.

Anaptys Announces Participation in November Investor Conferences

On November 1, 2023 AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, reported that Daniel Faga, president and chief executive officer of Anaptys, and/or other members of its senior management team are scheduled to participate in multiple upcoming investor conferences in November (Press release, AnaptysBio, NOV 1, 2023, View Source [SID1234636621]):

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Investor Conference Details

Guggenheim 5th Annual I&I Conference, New York, NY

Format – Fireside chat and one-on-one investor meetings
Date and Time – Tuesday, Nov. 7, 2023 at 9:50am ET / 6:50am PT
UBS Biopharma Conference 2023, Miami, FL

Format – One-on-one investor meetings
Date – Wednesday, Nov. 8, 2023
Stifel 2023 Healthcare Conference, New York, NY

Format – Fireside chat and one-on-one investor meetings
Date and Time – Wednesday, Nov. 15, 2023 at 12:40pm ET / 9:40am PT
Piper Sandler 35th Annual Healthcare Conference, New York, NY

Format – Fireside chat and one-on-one investor meetings
Date and Time – Wednesday, Nov. 29, 2023 at 2:00pm ET / 11:00am PT
Evercore ISI 6th Annual HealthCONx Conference, Miami, FL

Format – Fireside chat and one-on-one investor meetings
Date and Time – Thursday, Nov. 30, 2023 at 10:25am ET / 7:25am PT
Live webcasts of the fireside chats will be available on the investor section of the Anaptys website at View Source Replays of the webcasts will be available for at least 30 days following the events.

ALX Oncology Announces November Investor Conference Participation

On November 1, 2023 ALX Oncology Holdings Inc., ("ALX Oncology") (Nasdaq: ALXO), a clinical-stage immuno-oncology company developing therapies that block the CD47 checkpoint pathway, reported that management will participate in three upcoming investor conferences in November (Press release, ALX Oncology, NOV 1, 2023, View Source [SID1234636620]).

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2023 UBS BioPharma Conference
Format: Fireside chat with analyst, Dr. Colin Bristow
Date: Wednesday, November 8th
Time: 1:30 PM EST
Location: Miami Beach, FL
Webcast link: Available here

2023 Jefferies London Healthcare Conference
Format: Fireside chat with analyst, Michael Yee
Date: Tuesday, November 14th
Time: 3:00 PM GMT
Location: London, UK
Webcast link: Available here

2023 Piper Sandler Healthcare Conference
Format: Fireside chat with analyst, Christopher Raymond
Date: Tuesday, November 28th
Time: 4:30 PM EST
Location: New York, NY
Webcast link: Available here

The live webcasts for the UBS, Jefferies and Piper Sandler fireside chats can be accessed by visiting the Investors section of ALX Oncology’s website at www.alxoncology.com and selecting Events under the News and Events tab. A replay of the webcast will be archived for up to 90 days following the fireside chat date.

MOLECULAR PARTNERS TO PARTICIPATE IN THE TD COWEN 7TH ANNUAL FALL ONCOLOGY INNOVATION SUMMIT

On November 1, 2023 Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech company developing a new class of custom-built protein drugs known as DARPin therapeutics, reported that the Company will participate in a fireside chat at the TD Cowen 7th Annual Fall Oncology Innovation Summit on Friday, November 3, 2023 at 9:00 a.m. ET (Press release, Molecular Partners, NOV 1, 2023, View Source [SID1234636569]). Presenting on behalf of Molecular Partners will be Patrick Amstutz, Chief Executive Officer, and Dr. Philippe Legenne, acting CMO.

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A live webcast of the event will be available on the "News and Events" page in the "Events" section of the Company’s website. A replay of the webcast will be archived on the Company’s website for 90 days following the presentation date.