On April 13, 2023 Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer, reported that it will participate in four upcoming investor conferences (Press release, Allogene, APR 13, 2023, View Source [SID1234630029]).

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Canaccord Genuity – CG Horizons in Oncology Virtual
Thursday, April 20, 2023
8:00AM PT/11:00AM ET

BofA Securities 2023 Health Care Conference
Wednesday, May 10, 2023
4:20PM PT/7:20PM ET

The JMP Securities Life Sciences Conference
Monday, May 15, 2023
8:30AM PT/11:30AM ET

2023 RBC Capital Markets Global Healthcare Conference
Tuesday, May 16, 2023
1:35PM PT/4:35PM ET

Any available webcasts will be posted to the Company’s website at www.allogene.com under the Investors tab in the News and Events section. Following a live webcast, a replay will be available on the Company’s website for approximately 30 days.

On April 13, 2023 Alentis Therapeutics ("Alentis"), the Claudin-1 (CLDN1) company, reported $105 million in Series C financing (Press release, Alentis Therapeutics, APR 13, 2023, View Source [SID1234630028]). The funding round was led by Jeito Capital together with Novo Holdings A/S and RA Capital Management with participation from existing investors including BB Pureos Bioventures, Bpifrance through its InnoBio 2 fund and Schroders Capital.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The financing will support Phase II and Phase I programs of Alentis’ lead investigational products ALE.F02 and ALE.C04 respectively as well as the CLDN1 platform development.

"We are absolutely delighted with this support from our investors," said Dr. Roberto Iacone, CEO at Alentis Therapeutics. "There are huge unmet needs in organ fibrosis and cancer, and this funding enables us to continue with the important work we’re doing in the CLDN1 space and generate clinical data from both our programs. We can now aggressively develop CLDN1 biology in oncology and continue with the recruitment of our organ fibrosis trials while advancing our ADC and bi-specific antibodies."

Founder and CEO of Jeito Capital, Rafaèle Tordjman said, "We are totally convinced about the CLDN1 biology potential in multiple areas of fibrosis and oncology. Alentis has made significant progress in identifying target populations while developing programs and advancing the platform. We are committed to continuing our partnership with Alentis as they are the leading player in the CLDN1 space and are well positioned to generate meaningful clinical data within the next 1218 months."

Novo Holdings’ Senior Partner, Naveed Siddiqi will join the Alentis Therapeutics’ Board of Directors. "The Venture Investments team of Novo Holdings has an extensive track record of backing high-quality biotechs across Europe and the US developing novel treatments for unmet medical needs," said Naveed Siddiqi. "Alentis has pioneered a world-leading position in the Claudin-1 space and is led by highly capable drug developers. We were encouraged by exciting emerging preclinical data in oncology and the potential of Claudin-1 targeted therapeutics to treat a wide range of cancers where Claudin-1 is highly expressed. We are looking forward to supporting Alentis as it further advances its pipeline in the clinic with the proceeds of this round."

Since its $67 million Series B funding in June 2021, Alentis has made major strides: ALE.F02 MAD study completion is imminent; it has clearly defined the CLDN1+ cancer patient population, including T-cell excluded cancers to develop ALE.C04 in oncology; set-up the platform to engineer CLDN1 antibody drug conjugates and bispecific antibodies that the Series C will help to further develop; and is expanding its team of top talent.

On April 12, 2023 Nkarta, Inc. (Nasdaq: NKTX), a biopharmaceutical company developing engineered natural killer (NK) cell therapies to treat cancer, reported its participation at two upcoming investor conferences (Press release, Nkarta, APR 13, 2023, View Source [SID1234630001]):

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22ND Annual Needham Virtual Healthcare Conference
April 17, 2023
3:00 p.m. ET – fireside chat

Canaccord Genuity Horizons in Oncology Virtual Conference
April 20, 2023
3:00 p.m. ET – panel discussion

A simultaneous webcast of each event will be available on the Investors section of Nkarta’s website, www.nkartatx.com, and a replay will be archived on the website for approximately 90 days.

On April 12, 2023 Araris Biotech AG ("Araris" or "the Company"), a company pioneering a proprietary antibody-drug conjugate (ADC)-linker technology, reported that Samsung Venture Investment Corporation ("Samsung Ventures"), an investment corporation established to promote the development of new technologies, has invested in the Company in an independent deal ahead of its on-going series A funding (Press release, Araris Biotech, APR 12, 2023, View Source [SID1234651280]).

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The investment was made via Samsung Life Science Fund – created jointly between Samsung Biologics (KRX: 207940.KS) and Samsung C&T, and managed by Samsung Ventures – which reflects Samsung’s commitment to further explore and expand various business opportunities in biopharmaceuticals.

Araris Biotech is a company pioneering a proprietary antibody-drug conjugate (ADC)- linker technology, where its linker platform enables payload attachment to off the shelf antibodies without needing to re-engineer or reduce antibodies, resulting in highly homogenous, stable and potent ADC therapies in a cost and time efficient manner. It also has the potential to address challenges associated to ADCs, including solubility and unstable linkage issues.

The latest investment reflects Samsung’s commitment to further expanding its pipeline. Samsung, as a strategic investor, will collaborate on evaluating, manufacturing and developing assets with Araris using the Company’s proprietary ADC Technology, in close collaboration with Samsung affiliates involved in the discovery and development, and manufacturing of novel biologics.

"Araris has the potential to develop best-in-class ADC therapies, and we see room for collaboration in the manufacturing and development of new drugs," said John Rim, CEO of Samsung Biologics.

"We’re pleased to receive this support from Samsung, as well as the recognition of the potential of our linker-payload toolbox and conjugation technology in such a quickly growing ADC field," said Philipp Spycher, Ph.D., chief executive officer and co-founder of Araris Biotech. "We look forward to using these proceeds to further support our efforts in advancing our ADC candidates toward the clinic."

On April 12, 2023 Function Oncology, a company transforming the future of targeted cancer treatment with a CRISPR-powered precision medicine platform, reported an upcoming presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2023 Annual Meeting (Press release, Function Oncology, APR 12, 2023, View Source [SID1234630027]). The presentation will feature data from an acute myeloid leukemia (AML) cohort that demonstrate the power of Function Oncology’s CRISPR-based personalized functional genomics platform to profile and understand cancer in unprecedented and patient-specific detail.

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"These data underscore the powerful potential of our functional genomics platform to produce tailored treatment strategies," said Srihari Sampath, M.D., Ph.D., MPhil, co-founder and chief scientific officer. "In this study, our platform achieved very high sensitivity and specificity to identify gene dependencies driving individual patient responses, as well as high predictive value for observed clinical outcomes. For the first time, we are able to efficiently move beyond traditional gene sequencing to directly measuring gene function in order to define optimal therapeutic strategies for cancer patients."

Details of the presentation are as follows:
Title: A comprehensive CRISPR-enabled functional genomics profiling platform in Acute
Myeloid Leukemia (AML): pilot study and validation of Fx Heme
Format: Poster presentation
Abstract Number: 1062
Session Title: Session PO.CL09.03 – Precision Molecular Subtyping and Therapeutic Development
Date and Time: Sunday, April 16, 2023, 1:30 PM – 5:00 PM ET