Revolution Medicines, Inc. Prices $2.0 Billion in Concurrent Upsized Offerings of Common Stock and Convertible Senior Notes

On April 15, 2026 Revolution Medicines, a late-stage clinical oncology company developing targeted therapies for patients with RAS-addicted cancers, reported the pricing of its concurrent public offerings of 10,563,381 shares of common stock, at a public offering price of $142.00 per share, for aggregate gross proceeds of approximately $1.5 billion, and $500.0 million aggregate principal amount of 0.50% convertible senior notes due 2033 (the "notes"). The offering size of the common stock offering was increased from the previously announced offering size of $750.0 million and the offering size of the note offering was increased from the previously announced offering size of $250.0 million. The issuance and sale of the common stock and the notes are scheduled to settle on April 16, 2026 and April 17, 2026, respectively, subject to customary closing conditions. Revolution Medicines also granted the underwriters of the common stock offering a 30-day option to purchase up to an additional 1,584,506 shares of common stock. The completion of the common stock offering will not be contingent on the completion of the note offering, and the completion of the note offering will not be contingent on the completion of the common stock offering.

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J.P. Morgan, TD Cowen and Guggenheim Securities are acting as book-running managers for the note offering and the common stock offering. LifeSci Capital is acting as lead manager for the note offering and the common stock offering.

The notes will be senior, unsecured obligations of Revolution Medicines and will accrue interest at a rate of 0.50% per annum, payable semi-annually in arrears on May 1 and November 1 of each year, beginning on November 1, 2026. The notes will mature on May 1, 2033, unless earlier repurchased, redeemed or converted. Before February 1, 2033, noteholders will have the right to convert their notes only upon the occurrence of certain events. From, and including, February 1, 2033, noteholders may convert their notes at any time at their election until the close of business on the second scheduled trading day immediately before the maturity date. Revolution Medicines will settle conversions by paying or delivering, as applicable, cash, shares of its common stock or a combination of cash and shares of its common stock, at Revolution Medicines’ election. The initial conversion rate is 5.0302 shares of common stock per $1,000 principal amount of notes, which represents an initial conversion price of approximately $198.80 per share of common stock. The initial conversion price represents a premium of approximately 40.0% over the public offering price per share of common stock in the common stock offering. The conversion rate and conversion price will be subject to adjustment upon the occurrence of certain events.

The notes will be redeemable, in whole or in part (subject to certain limitations), for cash at Revolution Medicines’ option at any time, and from time to time, on or after May 6, 2030 and on or before the 31st scheduled trading day immediately before the maturity date, but only if the last reported sale price per share of Revolution Medicines’ common stock exceeds 130% of the conversion price for a specified period of time and certain other conditions are satisfied. The redemption price will be equal to the principal amount of the notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date.

If a "fundamental change" (as defined in the indenture for the notes) occurs, then, subject to a limited exception, noteholders may require Revolution Medicines to repurchase their notes for cash. The repurchase price will be equal to the principal amount of the notes to be repurchased, plus accrued and unpaid interest, if any, to, but excluding, the fundamental change repurchase date.

Revolution Medicines estimates that the net proceeds from the common stock offering will be approximately $1,435.0 million (or approximately $1,650.4 million if the underwriters of the common stock offering fully exercise their option to purchase additional shares of common stock), after deducting the underwriting discounts and commissions and estimated offering expenses. Revolution Medicines estimates that the net proceeds from the note offering will be approximately $486.8 million, after deducting the underwriting discounts and commissions and estimated offering expenses. Revolution Medicines intends to use the net proceeds from the offerings for general corporate purposes, including research and development expenses, expenses relating to the potential commercialization of one or more of its product candidates, general and administrative expenses and capital expenditures.

The offerings are being made pursuant to an effective shelf registration statement on file with the Securities and Exchange Commission (the "SEC"). Each offering will be made only by means of a prospectus supplement relating to that offering and an accompanying prospectus. An electronic copy of the preliminary prospectus supplement (and, when available, the final prospectus supplement) for each offering, together with the accompanying prospectus, is or will be available on the SEC’s website at www.sec.gov. Alternatively, copies of these documents can be obtained by contacting: J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717 or by email at [email protected] and [email protected]; TD Securities (USA) LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by email at [email protected]; and Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison Avenue, 8th Floor, New York, NY 10017, by telephone at (212) 518-9544, or by email at [email protected].

This press release does not constitute an offer to sell, or the solicitation of an offer to buy, any securities referred to in this press release, nor will there be any sale of any such securities, in any state or other jurisdiction in which such offer, sale or solicitation would be unlawful prior to registration or qualification under the securities laws of such state or jurisdiction.

(Press release, Revolution Medicines, APR 15, 2026, View Source [SID1234664363])

2026 First-Quarter sales data

On April 14, 2026 Johnson & Johnson reported first quarter 2026 financial results.

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(Filing, 3 mnth, MAR 31, Johnson & Johnson, 2026, APR 14, 2026, View Source [SID1234669151])

FDA accepts trade name Nilopki® for Xspray’s drug candidate XS003 (nilotinib)

On April 14, 2026 Xspray Pharma reported that the US Food and Drug Administration (FDA) has accepted Nilopki as the proprietary name for its drug candidate XS003 (nilotinib). Nilopki is an improved, amorphous formulation of nilotinib (Tasigna) for the treatment of chronic myeloid leukemia (CML), developed on Xspray’s proprietary HyNap platform. Upon market approval, Xspray plans to launch Nilopki in the US during the secont half of 2026, coordinated with the planned launch of Dasynoc.

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Xspray Pharma’s application for market approval (NDA) for Nilopki is under review by the FDA with a PDUFA date of June 18, 2026. The application is made under the 505(b)(2) procedure with Tasigna as the reference product. Nilopki is developed on Xspray’s proprietary HyNap platform and is an improved version of the reference product Tasigna.

"The name Nilopki gives our nilotinib candidate a clear identity ahead of a possible approval and an upcoming launch," says Per Andersson, CEO of Xspray Pharma. "With Dasynoc and Nilopki, we have the opportunity to launch two enhanced CML drugs in the US in the second half of 2026, subject to market approval. Because both reach the same prescribers and the same patients, we get full leverage on our commercial organization from day one."

Two crucial advantages of Nilopki
Nilopki effectively eliminates the requirement for fasting at dosing that currently forces Tasigna patients to abstain from food for up to six hours per day, one of the biggest challenges for adherence to CML treatment. The requirement is found in Tasigna’s boxed warning because concomitant food intake results in an 82 percent increase in exposure and thus an increased risk of heart rhythm disturbances (QT prolongation).

In clinical studies in healthy volunteers, Nilopki has shown reduced food interaction to 29 percent, which would be the lowest on the market if approved. Nilopki is expected to be taken with or without food. The food interaction warning is thus expected to be removed from Nilopki’s boxed warning.

The benefit profile is made possible by a simultaneous dose reduction. Nilopki has demonstrated matching bioavailability at 52 percent lower dose, thanks to the improved properties of the HyNap platform. A patient who currently takes 800 mg of Tasigna per day can get the same uptake in the blood with Nilopki with 384 mg. The rest today passes straight through the body.

Two CML products, one coordinated launch
Xspray’s lead drug candidate Dasynoc (dasatinib) is also being reviewed by the FDA, with a PDUFA date of August 25, 2026, for the treatment of CML and acute lymphoblastic leukemia (ALL). Upon market approval, Xspray plans to launch both products in the US in the second half of 2026. The launch plan assumes that the previously communicated GMP-issues at the contract manufacturer NerPharMa have been addressed prior to the FDA’s decision, in line with what the company previously reported.

Since both target the same CML prescribers and the same patient population, a coordinated rollout creates clear synergies in areas such as market access, sales and patient support programs, where Xspray has a well-established collaboration with EVERSANA. Xspray thus addresses the entire US CML market, which in 2025 had sales of approximately USD 6.6 billion and grew by about 12 percent.

(Press release, Xspray, APR 14, 2026, View Source [SID1234666040])

Mestag Therapeutics Selected to Present Targeted LTBR Agonist MST‑0312 in Late‑Breaking Session at AACR Annual Meeting

On April 14, 2026 Mestag Therapeutics, a biotech company harnessing fibroblast immunology to develop impactful treatments for patients with cancer and inflammatory disease, reported that it has been selected to present a late‑breaking poster at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting taking place April 17–22, 2026 in San Diego, California.

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The poster presentation entitled "MST‑0312: Targeted LTBR Agonist Designed to Induce Tertiary Lymphoid Structures and High Endothelial Venules for the Treatment of Solid Tumors," will detail pre-clinical findings from its FAP‑targeted LTBR agonist program, presented by Pascal Merchiers, Chief Development Officer.

Details of the late-breaking poster presentation are as follows:

Poster Title: MST‑0312: Targeted LTBR Agonist Designed to Induce Tertiary Lymphoid Structures and High Endothelial Venules for the Treatment of Solid Tumors
Session Title: Late-Breaking Research: Immunology 3
Session Date and Time: Tuesday, April 21, 2026, 9:00am – 12:00pm
Location: Poster Section 53
Abstract Presentation Number: LB257

Late-breaking abstracts will be available in an online itinerary planner here on April 17.

MST-0312 is a FAP-targeted LTBR agonist bispecific antibody designed to induce the formation of tertiary lymphoid structures (TLS) and high endothelial venules (HEV) in solid tumors. A substantial body of clinical evidence demonstrates that the presence of TLS and HEV in tumors is associated with improved patient survival and enhanced responses to therapy, reflecting their role in facilitating lymphocyte access to the tumor and local education. LTBR activation is the key pathway driving TLS/HEV formation.

MST‑0312 is anticipated to enter clinic mid‑2026 with the initiation of the Phase 1 STARLYS trial.

(Press release, Mestag Therapeutics, APR 14, 2026, View Source [SID1234664393])

CERo Therapeutics Doses Third Patient in Cohort 2 of Phase 1 CER-1236 Trial

On April 14, 2026 CERo Therapeutics Holdings, Inc., (OTCQB: CERO) ("CERo" or the "Company") an innovative cellular immunotherapy company seeking to advance the next generation of engineered T cell therapeutics that employ phagocytic mechanisms, reported it has dosed the third patient in the second cohort (sixth patient overall) in its Phase 1 CER-1236 clinical trial in hematologic malignancies. The patient had MDS that evolved to acute myeloid leukemia (AML). The trial was recently expanded to include earlier forms of MDS and myelofibrosis (MF).

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The study continues to progress in accordance with protocol, with patients undergoing monitoring for safety, pharmacokinetics, pharmacodynamics, and clinical activity. With more than seven days of follow-up completed after the most recent infusion, CERo continues to evaluate key endpoints across dose levels as it advances through dose escalation.

As previously presented at the February Tandem Meetings in Salt Lake City, CER-1236 has demonstrated no reported cases of cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS) of any grade, and no dose-limiting toxicities observed during the 28-day assessment window. Investigators also reported in vivo cell expansion, with peak levels observed between days 10 and 14 following infusion. Additionally, as previously reported, a single patient with inv(3) AML who received four CER-1236 infusions over five months at the lowest dose level achieved 72 consecutive days of platelet transfusion independence. These findings informed the protocol amendment expanding enrollment into patients with MDS and MF.

Robert Sikorski, M.D., Ph.D., CERo Chief Medical Officer, stated, "This is the third patient in the cohort, and completion of the dose-limiting toxicity evaluation period may enable further dose escalation in accordance with the protocol. We continue to evaluate the safety profile and early clinical data as CER-1236 is studied in patient populations with significant unmet need."

The first-in-human, multi-center, open-label Phase 1/1b study is designed to evaluate the safety and preliminary efficacy of CER-1236. The trial was initially focused on AML patients, including those with relapsed/refractory disease, measurable residual disease, or newly diagnosed TP53-mutated AML, and has since expanded to include transfusion-dependent MDS (TD-MDS), high-risk MDS (HR-MDS), and post-JAK inhibitor myelofibrosis (MF). Primary endpoints include safety and tolerability, while secondary endpoints include pharmacokinetics and measures of clinical response, including overall response rate (ORR), complete response (CR), composite complete response (cCR), and measurable residual disease (MRD).

CERo Chief Executive Officer Chris Ehrlich added, "Dosing our sixth patient and expanding into MDS represents continued execution of the CERTAIN-T trial and an important milestone for CERo. We believe CER-1236 has the potential to address multiple hematologic malignancies, and we look forward to further advancing the study and sharing additional clinical updates."

(Press release, Cero Therapeutics, APR 14, 2026, View Source [SID1234664392])