Prothena to Report First Quarter 2023 Financial Results on May 4

On April 27, 2023 Prothena Corporation plc (NASDAQ:PRTA), a late-stage clinical biotechnology company with a robust pipeline of investigational therapeutics built on protein dysregulation expertise, reported that it will report its first quarter 2023 financial results on Thursday, May 4, 2023 after the close of the U.S. financial markets (Press release, Prothena, APR 27, 2023, View Source [SID1234630631]).

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Consistent with past practice, the Company will not be conducting a conference call in conjunction with this financial results release on May 4.

Autolus Therapeutics announces Pivotal Phase 2 FELIX study of obe-cel in adult r/r B-ALL selected for an oral presentation at ASCO

On April 27, 2023 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported that the abstract for the pivotal Phase 2 FELIX study of obecabtagene autoleucel (obe-cel) in relapsed/refractory (r/r) adult B-cell Acute Lymphoblastic Leukemia (ALL) has been selected for an oral presentation at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, being held June 2 – 6, 2023, in Chicago (Press release, Autolus, APR 27, 2023, View Source [SID1234630630]).

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ASCO Oral Presentation, abstract #7000:

Title: Safety and efficacy of Obecabtagene autoleucel (obe-cel, AUTO1), a fast-off rate CD19CAR in relapsed/refractory adult B-Cell acute lymphoblastic leukemia (r/r B-ALL): Topline results of the pivotal FELIX study

Session Title: Hematologic Malignancies — Leukemia, Myelodysplastic Syndromes, and Allotransplant

Session date and time: Friday, June 2, 2023, 14:00 – 17:00 EDT, 19:00 – 22:00 BST

Presenting Author: Dr. Claire Roddie, MD, PhD, FRCPath, Consultant Haematologist and Honorary Senior Lecturer, Cancer Institute, University College London (UCL)

Medigene to Present Expitope 3.0 at the 20th Annual Meeting of the Association for Cancer Immunotherapy (CIMT)

On April 27, 2023 Medigene AG (Medigene, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, reported that it will be presenting at the 20th Association for Cancer Immunotherapy (CIMT) (Free CIMT Whitepaper) annual meeting being held on May 3-5, 2023, in Mainz (Press release, MediGene, APR 27, 2023, View Source [SID1234630629]).

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The data to be presented will focus on Expitope 3.0, an in silico tool to identify immunogenic epitopes as suitable T cell receptor (TCR) target specificities. Moreover, Expitope 3.0, enables the comparison of expression of epitopes in various healthy tissues to predict potential cross-reactivity and off-target toxicity. Presentation of the data includes a poster as well as an oral presentation.

The abstract has been published online: View Source

Details on the poster presentation are as follows:

Abstract and Title: "Expitope 3.0 – An Advanced in silico Webtool Empowered with Machine Learning for Enhanced pHLA Epitope Prediction and Safety Assessment"

Authors: Sebastian Karg, Andrea Coluccio, Barbara Lösch, Dolores J Schendel, Dimitri Frishmann

Abstract Number: 98

Date/Time: Wednesday, May 3rd, 2023, 3:00 pm – 5.30 pm CET

Session: Postersession I

Details on the oral presentation are as follows:

Abstract and Title: "Expitope 3.0 – An Advanced in silico Webtool Empowered with Machine Learning for Enhanced pHLA Epitope Prediction and Safety Assessment"

Speaker: Dr. Barbara Lösch

Date/Time: Thursday, May 4th, 2023, 11.00 am – 11.15 am CET

Veracyte Announces Five Abstracts Providing Molecular Insights Into Prostate and Other Cancers To Be Presented at the 2023 ASCO Annual Meeting

On April 27, 2023 Veracyte, Inc. (Nasdaq: VCYT) reported that five abstracts providing new molecular insights into prostate and other cancers will be presented at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place in Chicago and online June 2-6 (Press release, Veracyte, APR 27, 2023, View Source [SID1234630628]). Three of the accepted abstracts leverage Veracyte’s Decipher GRID (Genomic Resource for Intelligent Discovery) database to explore potential opportunities for further personalizing treatment for patients with prostate cancer.

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"At Veracyte, we are committed to partnering with the scientific community to uncover new insights that may ultimately help further transform cancer care for patients," said Marc Stapley, Veracyte’s chief executive officer. "We particularly look forward to study findings being presented at ASCO (Free ASCO Whitepaper) that leverage our Decipher GRID database to explore differences in how patients with prostate cancer might respond to particular treatments based on their genomic profiles, and that demonstrate our deep scientific capabilities in immuno-oncology."

The following abstracts will be presented at the 2023 ASCO (Free ASCO Whitepaper) Annual Meeting:

Title: Longitudinal transcriptome profiling of localized hormone-sensitive tumors in treatment-naïve ENACT patients with prostate cancer with and without enzalutamide (ENZA)
Presenter: Ashley Ross, M.D., Ph.D., Northwestern University Feinberg School of Medicine
Abstract #: 5026
Format: Poster
Date/Time: June 3, 2023, 8:00-11:00 a.m. CT
Location: McCormick Place, Hall A (Poster #120)

Title: Basal-luminal subtyping of localized high-risk prostate cancer and benefit of adding docetaxel to definitive radiotherapy with androgen suppression in the NRG Oncology/RTOG 0521 phase III trial
Presenter: Ryan Phillips, M.D., Ph.D., Mayo Clinic
Abstract #: 5094
Format: Poster
Date/Time: June 3, 2023, 8:00-11:00 a.m. CT
Location: McCormick Place, Hall A (Poster #188)

Title: Transcriptomic heterogeneity of metastatic disease timing within metastatic castration-sensitive prostate cancer
First Author: Philip Sutera, M.D., Johns Hopkins University
Abstract #: e17083
Format: Publication Only

Title: Biology and performance of pre- and post-pembrolizumab (Pembro) vesical imaging–reporting and data system (VI-RADS) to predict the pathological response in muscle-invasive urothelial bladder cancer (MIBC): Full data analysis from a clinical trials pipeline
Presenter: Andrea Necchi, M.D., Vita-Salute San Raffaele University
Abstract #: 4591
Format: Poster
Date/Time: June 3, 2023, 8:00-11:00 a.m. CT
Location: McCormick Place, Hall A (Poster #83)

Title: FOLFOXIRI plus bevacizumab and atezolizumab as upfront treatment of unresectable metastatic colorectal cancer (mCRC): Updated and overall survival results of the phase II randomized AtezoTRIBE study.
Presenter: Carlotta Antoniotti, M.D., Ph.D., Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa & Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana
Abstract #: 3500
Format: Oral Presentation
Date/Time: June 4, 2023, 8:00 a.m. CT
Location: McCormick Place, Hall D2

Tempest to Report Early Results from Global Randomized Phase 1b/2 Combination Study of TPST-1120 in First-Line Hepatocellular Carcinoma

On April 27, 2023 Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage oncology company developing first-in-class1 therapeutics that combine both targeted and immune-mediated mechanisms, reported that the company plans to report early data from its Phase 1b/2 combination study of TPST-1120 in first-line hepatocellular carcinoma in a premarket press release and webcast Friday, April 28, 2023 (Press release, Tempest Therapeutics, APR 27, 2023, View Source [SID1234630627]).

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Tempest will host a conference call accompanied by a slide presentation at 8:30 a.m. ET on Friday, April 28th. To join the conference call via phone and participate in the live Q&A session, please pre-register online here to receive a telephone number and unique passcode required to enter the call. The live webcast and audio archive of the presentation may be accessed on the investor section of the Tempest website at View Source The webcast will be available for replay for 30 days.