Entry into a Material Definitive Agreement

On March 14, 2023 Adamis Pharmaceuticals Corporation, a Delaware corporation (the "Company", "we", "our" or "us"), reported that it has entered into a Securities Purchase Agreement (the "SPA") with an investor (the "Purchaser"), providing for the purchase and sale of (i) an aggregate of 16,500,000 shares (the "Shares") of the Company’s common stock, par value $0.0001 per share (the "Common Stock"), at a price of $0.125 per Share, (ii) a warrant to purchase up to an aggregate of 48,000,000 shares of our Common Stock at an exercise price of $0.138 per share (the "Common Stock Warrant"), and (iii) a prefunded warrant to purchase up to an aggregate of 7,500,000 shares of our Common Stock at a price of $0.1249 per share (the "Prefunded Warrant" and, collectively with the Common Stock Warrant, the "Warrants"), which represents the per share price for the Shares less the $0.0001 per share exercise price for the Prefunded Warrant, pursuant to a registration statement on Form S-3 (Registration No. 333-267365) that was filed with the Securities and Exchange Commission (the "SEC") on September 9, 2022, and became effective on September 19, 2022, and the prospectus contained therein, as supplemented by the prospectus supplement, dated March 14, 2023 in a registered direct offering (the "Offering") (Filing, 8-K, Adamis Pharmaceuticals, MAR 14, 2023, View Source [SID1234628674]). The Prefunded Warrant is immediately exercisable and will expire five years from the date of issuance. The Common Stock Warrant is exercisable on or after the six month and one day anniversary of the date of issuance and will expire five years and six months from the date of issuance.

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The gross proceeds to us from the Offering are expected to be approximately $3.0 million, before deducting offering expenses. The Company intends to use the net proceeds from the Offering for general corporate purposes, which may include, without limitation, manufacturing, capital expenditures, the payment, repayment, refinancing, redemption or repurchase of existing or future indebtedness, obligations or capital stock, payment of obligations and liabilities, and working capital.

Pursuant to the terms of the SPA, the Company and its subsidiaries have agreed not to offer, sell, transfer or otherwise dispose of any shares of the Company’s Common Stock during the 90-day period following the closing date of the Offering, subject to certain exceptions.

The SPA contains customary representations, warranties and agreements of the Company and the Purchaser, customary conditions to closing and indemnification rights and obligations customary for transactions of this type. In addition, in connection with the SPA, the parties entered into a voting agreement pursuant to which the Purchaser agreed to vote the Shares, together with any additional shares of Common Stock beneficially owned by the Purchaser and its affiliates, in favor of certain matters. The provisions of the SPA, including the representations and warranties contained therein, are not for the benefit of any party other than the parties to such agreement and are not intended as a document for investors and the public to obtain factual information about the current state of affairs of the Company. Rather, investors and the public should look to other disclosures contained in the Company’s filings with the SEC.

Warrants

Duration and Exercise Price

The Common Stock Warrant will have an exercise price of $0.138 per share, will be exercisable on or after the six month and one day anniversary of the date of issuance and will expire five years and six months from the date of issuance. The Prefunded Warrant will be immediately exercisable and will expire five years from the date of issuance. If we fail to deliver any shares of Common Stock issuable upon exercise of the Warrants (the "Warrant Shares"), the Warrants (i) require us to make "buy-in" payments and (ii) subject us to certain degrees of liquidated damages for each $1,000 of Warrant Shares subject to such exercise. The exercise price and number of Warrant Shares issuable upon exercise is subject to appropriate adjustment in the event of stock dividends, stock splits, reorganizations or similar events affecting the Common Stock.

Exercisability

The Warrants will be exercisable, at the option of the holder, in whole or in part, by delivering a duly executed exercise notice accompanied by payment in full for the number of Warrant Shares purchased upon such exercise (except in the case of a cashless exercise as discussed below). The holder (together with its affiliates) may not exercise a Warrant to the extent that we do not have sufficient authorized but unissued shares of Common Stock to effect such exercise. In addition, the holder (together with its affiliates) may not exercise a (i) Common Stock Warrant to the extent that the holder would own more than 4.99% (or, at the election of the holder, up to 9.99%) of the outstanding Common Stock immediately after exercise (the "Beneficial Ownership Limitation"), except that upon at least 61 days’ prior written notice from the holder to us, the holder may increase the amount of the Beneficial Ownership Limitation up to 9.99%, as such ownership percentage is determined in accordance with the terms of the Common Stock Warrant, or (ii) Prefunded Warrant to the extent that the holder would own more than 9.99% of the outstanding Common Stock immediately after exercise. No fractional shares of Common Stock will be issued in connection with the exercise of a Warrant. In lieu of fractional shares, we will pay the holder the cash value of any fractional shares otherwise issuable. If at the time of exercise of a Warrant, there is no effective registration statement registering the shares of Common Stock underlying the Warrant, such Warrant may be exercised on a cashless basis pursuant to its terms

Cashless Exercise

If, at the time the holder exercises its Warrants, a registration statement registering, or a current prospectus available for, the resale of the Warrant Shares underlying the Warrants under the Securities Act of 1933, as amended, is not then effective or available, the holder may elect instead to receive upon such exercise (either in whole or in part) the net number of shares of Common Stock determined according to a formula set forth in the Warrants.

Fundamental Transaction

In the event of a fundamental transaction, as described in the Warrants and generally including any reorganization, recapitalization or reclassification of the Common Stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more than 50% of our outstanding voting securities, the holder of the Warrants will be entitled to receive upon exercise of the Warrants the kind and amount of securities, cash or other property that the holder would have received had it exercised the Warrants immediately prior to such fundamental transaction. In addition, the holder of the Warrants has the right to require us or a successor entity to redeem the unexercised Warrants for the cash paid in the fundamental transaction in the amount receivable as a result of such fundamental transaction by the holder of the number of Warrant Shares for which the Warrants are exercisable immediately prior to such fundamental transaction.

Redemption Upon Change of Control

At the request of the holder following a change of control, the Company or the successor entity, as the case may be, shall purchase the Warrant from the holder for an amount in cash equal to the Black Scholes Value (as defined in the Warrant).

Transferability

Subject to applicable laws, a Warrant may be transferred at the option of the holder upon surrender of the Warrant to us together with the appropriate instruments of transfer and payment of funds sufficient to pay any transfer taxes (if applicable).

Rights as a Stockholder

Except as otherwise provided in the Warrants or by virtue of such holder’s ownership of shares of Common Stock, the holder of the Warrants does not have the rights or privileges of holders of our Common Stock, including any voting rights, until it exercises its Warrants.

The foregoing descriptions of the SPA, the Form of Common Stock Warrant and the Form of Prefunded Warrant are summaries of their material terms, do not purport to be complete, and are qualified in their entirety by reference to each of the Form of Common Stock Warrant, the Form of Prefunded Warrant and the SPA, copies of which are being filed as Exhibits 4.1, 4.2 and 10.1, respectively, to this Current Report on Form 8-K and are incorporated herein by reference.

A copy of the legal opinion and consent of Latham & Watkins LLP relating to the Offering is attached as Exhibit 5.1 hereto.

On March 14, 2023, the Company issued a press release announcing the Offering described above, a copy of which is attached hereto as Exhibit 99.1.

Forward-Looking Statements

This report contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this report that do not relate to matters of historical fact should be considered forward-looking statements including, without limitation, statements regarding the anticipated amount of gross proceeds from the Offering and the intended use of such proceeds. These and other important factors discussed under the caption "Risk Factors" in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 filed with the SEC, the Company’s Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2022, and the Company’s other filings with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements made in this report. Any forward-looking statements speak only as of the date of this report and are based on information available to the Company as of the date of this report, and the Company assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise.

Vincerx Pharma Announces Poster Presentations at the American Association for Cancer Research (AACR) Annual Meeting 2023

On March 14, 2023 Vincerx Pharma, Inc. (Nasdaq: VINC), a biopharmaceutical company aspiring to address the unmet medical needs of patients with cancer through paradigm-shifting therapeutics, reported four poster presentations at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2023, being held virtually and at the Orange County Convention Center in Orlando, Florida from April 14-19, 2023 (Press release, Vincerx Pharma, MAR 14, 2023, View Source [SID1234628667]).

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Poster presentation details:

Poster Title: VIP236: A small molecule drug conjugate with an optimized camptothecin payload has significant activity in patient-derived and metastatic cancer models
Abstract Number: 484
Presenter: Beatrix Stelte-Ludwig, PhD
Session Type: In-Person Poster Presentation
Session Title: Novel Antitumor Agents 1
Session Time: Sunday, April 16, 2023 at 1:30 PM ET
Location: Poster Section 17; Poster Board Number 15

Poster Title: Targeting CDK9 via the small-molecule inhibitor enitociclib as a therapeutic strategy to treat MYCN-amplified rhabdomyosarcoma and neuroblastoma in children
Abstract Number: 1558
Presenter: Andy Tran
Session Type: In-Person Poster Presentation
Session Title: Cell Cycle/Cell Proliferation Inhibitors for Cancer Therapy
Session Time: Monday, April 17, 2023 at 9:30 AM ET
Location: Poster Section 15; Poster Board Number 6

Poster Title: Synthesis and characterization of novel small molecule drug conjugates with different payloads designed to be released in tumor microenvironment by neutrophil elastase
Abstract Number: 2722
Presenter: Hans-Georg Lerchen, PhD
Session Type: In-Person Poster Presentation
Session Title: Drug Delivery Systems
Session Time: Monday, April 17, 2023 at 1:30 PM ET
Location: Poster Section 15; Poster Board Number 25

Poster Title: CXCR5 is a very promising drug target for the development of antibody-drug conjugates to treat patients with lymphoma
Abstract Number: 6294
Presenter: Tibor Schomber, PhD
Session Type: In-Person Poster Presentation
Session Title: Growth Factor Receptors as Therapeutic Targets
Session Time: Wednesday, April 19, 2023 at 9:00 AM ET
Location: Poster Section 21; Poster Board Number 1

A copy of the presentation materials can be accessed on the Investors section of the Company’s website at www.vincerx.com once each presentation has concluded.

VBL Therapeutics Reports Full Year 2022 Financial Results and Provides Corporate Update

On March 14, 2023 VBL Therapeutics (Nasdaq: VBLT) (VBL), reported financial results for the fiscal year ended December 31, 2022, and provided a corporate update (Press release, VBL Therapeutics, MAR 14, 2023, View Source [SID1234628666]).

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"I am confident that the recently announced merger with Notable Labs Inc. provides the best path forward and will position the new enterprise to deliver both near and long-term value for shareholders of both companies and patients," said Prof. Dror Harats, M.D., Chief Executive Officer of VBL Therapeutics. "The successful closing of the sale of VBL’s manufacturing facility for $7.1 million has provided an influx of non-dilutive capital that can be employed by the combined entity to advance its pipeline. I am impressed by the management team at Notable, who have an excellent track record developing successful pharmaceuticals, and the vision to create a leading clinical stage oncology company utilizing Notable’s Predictive Precision Medicine Platform."

Recent Corporate Highlights

On February 23, 2023 VBL announced that it entered into a definitive merger agreement with Notable Labs Inc. (Notable). The combined company will focus on the advancement of Notable’s proprietary Predictive Precision Medicines Platform (PPMP) and therapeutic pipeline focused on cancer patients with high unmet medical needs.
Notable has applied its PPMP to selecting and developing two clinical-stage therapeutic candidates in acute myeloid leukemia (AML); Phase 2a results for lead asset Volasertib in adult AML in platform-predicted responding patients are expected in 3Q 2024.
Results from a new clinical validation study of Notable’s PPMP will be presented at a medical conference in the second quarter of 2023.
The combined company will be led by Notable’s current management team and will be headquartered in Foster City, California.
Upon closing of the merger, Notable stockholders are expected to own approximately 76% and VBL shareholders are expected to own approximately 24% of the combined company, each on a fully-diluted basis and subject to adjustment.
The combined company is expected to operate under the name Notable Labs, Ltd. with its shares listed on the Nasdaq Capital Market under the ticker symbol ‘NTBL.’
Concurrent with the execution of the merger agreement, a healthtech-focused investor syndicate, including existing Notable stockholders Builders VC, B Capital Group, Y Combinator, First Round Capital, and Founders Fund, entered into a definitive securities purchase agreement with Notable to invest $10.3 million in gross proceeds prior to the close of the proposed merger. After completion of the merger, the combined company is expected to have a cash runway into 2025.

On March 9, 2023, VBL closed the previously announced sale of the rights to its Modi’in manufacturing facility, along with certain tangible assets and equipment located therein for $7.1 million in cash.
Financial Results for the Full Year 2022

On December 31, 2022, VBL had cash, cash equivalents, short-term bank deposits and restricted bank deposits of $21.1 million. In addition, in March 2023, VBL received $7.1 million in proceeds from the sale of VBL’s Modi’in manufacturing facility and certain related assets.
For the year ended December 31, 2022, VBL reported a net loss of $32.3 million, or ($0.42) per basic share, compared to a net loss of $29.9 million, or ($0.45) per basic share, in the comparable period in 2021.
Revenues for the year ended December 31, 2022 were $0.7 million, compared to $0.8 million for the year ended December 31, 2021, a decrease of $0.1 million. The decrease is due to the winding down of the revenue recognized from the terminated Nanocarrier license agreement.
For the year ended December 31, 2022, total operating expenses were approximately $33.4 million, consisting of $21.7 million in research and development expenses, net, and $11.8 million in general and administrative expenses. This compares with total operating expenses of $30.4 million in the year ended December 31, 2021, which was comprised of $22.7 million in research and development expenses, net, and $7.7 million in general and administrative expenses.

Theratechnologies to Present Preclinical Data at AACR Demonstrating Synergy Between TH1902 and Anti-PD-L1 Immunotherapy in Cold Tumor Model

On March 14, 2023 Theratechnologies Inc. ("Theratechnologies" or the "Company") (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, reported that new data will be presented demonstrating the promise of its SORT1+ Technology platform of proprietary peptides, and of its lead investigational peptide drug conjugate (PDC) candidate, sudocetaxel zendusortide (TH1902), in enabling targeted delivery of anticancer therapy (Press release, Theratechnologies, MAR 14, 2023, View Source [SID1234628665]).

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The new data, to be presented in three poster sessions at the 2023 annual meeting of the American Association for Cancer Research (AACR) (Free AACR Whitepaper) being held April 14-19 in Orlando, Fla., highlight a synergistic effect of sudocetaxel zendusortide in combination with programmed death-ligand 1 (PD-L1), checkpoint inhibitor therapy in a melanoma mouse model; high expression of the sortilin (SORT1) receptor in multiple tumor types compared to healthy tissues; and the rationale for using sudocetaxel zendusortide as a potential therapeutic approach in SORT1-positive triple-negative breast cancer (TNBC) and HER2-positive breast cancers.

"We are particularly encouraged by the potential synergistic activity of sudocetaxel zendusortide when combined with an anti-PD-L1 checkpoint inhibitor in a melanoma model," said Christian Marsolais, Ph.D., Senior Vice President and Chief Medical Officer of Theratechnologies. "Our new data continue to support the clinical development of sudocetaxel zendusortide as a single agent and in combination with other anticancer therapies. Together, the AACR (Free AACR Whitepaper) poster presentations provide fresh insights to guide our oncology program, and our efforts to bring advanced personalized therapies to patients with cancer."

Theratechnologies will present the following data on Tuesday April 18, 2023, from 9:00am-12:30pm Eastern Time (ET) at AACR (Free AACR Whitepaper) 2023:

Title: The peptide-drug conjugate sudocetaxel zendusortide (TH1902) potentiates anti-tumoral activity of the anti-PD-L1 checkpoint inhibitor and induces immune cell infiltration in a B16-F10 syngeneic melanoma model

Presenting Author: Michel Demeule, Ph.D., Theratechnologies
Session Category: Clinical Research Excluding Trials
Session Title: Molecular Targeted Therapies 2
Location: Poster Section 42
Poster Board Number: 24
Abstract Presentation Number: 4499
Title: Sudocetaxel zendusortide (TH1902), a peptide-drug conjugate for the treatment of sortilin-positive (SORT1+) TNBC and Her2-positive breast cancers

Presenting Author: Cyndia Charfi, Ph.D., Theratechnologies
Session Category: Clinical Research Excluding Trials
Session Title: Molecular Targeted Therapies 2
Location: Poster Section 42
Poster Board Number: 18
Abstract Presentation Number: 4493
Title: Differential expression of a novel transport receptor, SORT1 (sortilin), in cancer versus healthy tissues that can be utilized for targeted delivery of anti-cancer drugs

Presenting Author: Guylaine Roy, Ph.D., Theratechnologies
Session Category: Experimental and Molecular Therapeutics
Session Title: Identification of Molecular Targets 1
Location: Poster Section 17
Poster Board Number: 30
Abstract Presentation Number: 3942
About SORT1+ Technology and Sudocetaxel Zendusortide (TH1902)

Theratechnologies is currently developing a platform of proprietary peptides called SORT1+ TechnologyTM for cancer drug development targeting SORT1 receptors. The SORT1 receptor plays a significant role in protein internalization, sorting and trafficking. It is highly expressed in cancer cells compared to healthy tissue, which makes SORT1 an attractive target for cancer drug development. Expression of SORT1 is associated with aggressive disease, poor prognosis and decreased survival. It is estimated that the SORT1 receptor is expressed in 40% to 90% of cases of endometrial, ovarian, colorectal, triple-negative breast and pancreatic cancers.

Sudocetaxel zendusortide (TH1902) is currently Theratechnologies’ lead investigational peptide drug conjugate candidate for the treatment of cancer derived from its SORT1+ Technology. It is the Company’s proprietary peptide linked to docetaxel – a commonly used cytotoxic agent used to treat many cancers. The FDA granted fast track designation to TH1902 as a single agent for the treatment of all sortilin-positive recurrent advanced solid tumors that are refractory to standard therapy. TH1902 is currently being evaluated in a Phase 1 clinical trial, although patient recruitment was voluntarily paused on December 1, 2022. In alignment with this decision, the FDA placed the trial on partial clinical hold and the Company is currently preparing responses to their questions and planning a protocol amendment.

Tempest to Present New Translational and Preclinical Data at the 2023 AACR Annual Meeting

On March 14, 2023 Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage oncology company developing first-in-class1 therapeutics that combine both targeted and immune-mediated mechanisms, reported that two abstracts have been accepted for poster presentation at the 2023 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting taking place April 14-19, 2023 in Orlando, FL (Press release, Tempest Therapeutics, MAR 14, 2023, View Source [SID1234628664]). The presentations will highlight biomarker data from the Phase 1 trial of TPST-1120, an oral selective PPAR⍺ antagonist and preclinical data from TREX1 inhibitor, a tumor-selective STING pathway activator.

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Poster presentation details:

Title: Lipid and immune-based biomarkers associated with clinical response to TPST-1120: A small molecule antagonist of peroxisome-proliferator activated receptor-alpha

Session Category: Clinical Research Excluding Trials
Session Title: Biomarkers of Therapeutic Benefit 2
Session Date & Time: Monday, April 17, 2023 9:00 a.m. – 12:30 p.m. ET
Location: Poster Section 39
Abstract Number: 2130

Title: Generation of novel potent human TREX1 inhibitors facilitated by crystallography

Session Category: Experimental and Molecular Therapeutics
Session Title: Novel Antitumor Agents 3
Session Date & Time: Monday, April 17, 2023 9:00 a.m. – 12:30 p.m. ET
Location: Poster Section 17
Abstract Number: 1636
___________________________

1 If approved by the FDA

Abstracts are available for viewing via the AACR (Free AACR Whitepaper) Online Itinerary Planner located here, View Source!/10828.