The Caris Precision Oncology Alliance Welcomes University of Chicago Medicine Comprehensive Cancer Center

On March 8, 2023 Caris Life Sciences(Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare, reported that the University of Chicago (UChicago) Medicine Comprehensive Cancer Center has joined the Caris Precision Oncology Alliance (POA) (Press release, Caris Life Sciences, MAR 8, 2023, View Source [SID1234628359]). The POA is a growing network of leading cancer centers across the globe that collaborate to advance precision oncology and biomarker-driven research. POA members work together to establish and optimize standards of care for molecular testing through innovative research focused on predictive and prognostic markers that improve the clinical outcomes for cancer patients.

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The UChicago Medicine Comprehensive Cancer Center includes more than 200 cancer specialists who offer innovative treatments, leading-edge research and clinical trials not available elsewhere in the Midwest. UChicago Medicine scientists study disease at the molecular level and clinical researchers apply the knowledge discovered in the institution’s laboratories to create and test promising new cancer treatments and procedures. The academic health system’s physician-scientists also specialize in cancer control, prevention and population research while implementing new approaches to screening and prevention. The institution is one of two NCI-designated comprehensive cancer centers in Illinois and a key part of its mission is community research to eliminate health disparities between ethnic and social groups.

"As home to a National Cancer Institute-designated Comprehensive Cancer Center, UChicago Medicine is excited to join colleagues across the country in this collaborative effort to advance precision medicine," said Walter M. Stadler, M.D., Senior Advisor to the Director of the UChicago Medicine Comprehensive Cancer Center and Dean for Clinical Research. "We look forward to working with colleagues throughout the country to translate genomic data into better care for cancer patients here in Chicago and around the world."

"We are excited to welcome the UChicago Medicine Comprehensive Cancer Center to the growing Precision Oncology Alliance network," said Chadi Nabhan, M.D., MBA, FACP, Chairman of the Caris Precision Oncology Alliance. "As a former UChicago Medicine faculty member, I know firsthand the dedication its physicians and researchers have to providing the most advanced and innovative therapies available to their patients. Our missions are the same – to improve the outcomes of all patients suffering from cancer through precision medicine."

The Caris Precision Oncology Alliance includes 79 cancer centers and academic institutions. These institutions have early access to the extensive database and artificial intelligence platform within Caris to establish evidence-based standards for cancer profiling and molecular testing in oncology. By leveraging the comprehensive genomic, transcriptomic and proteomic profiling available through Caris molecular profiling, Caris seeks to provide this network with the ability to prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients. POA members are also able to integrate with a growing portfolio of biomarker directed trials sponsored by biopharma. Additionally, as a member of the POA, institutions have access to Caris CODEai, the most comprehensive data solution in the industry with cancer treatment information and clinical outcomes data for over 350,000 patients covering over 1 million data points per patient.

Estrella Biopharma Announces FDA Clearance of IND Application for Phase I/II Clinical Trial (Starlight-1) of EB103, a CD19-Targeted ARTEMIS® T Cell Therapy, to Patients with B-Cell Lymphomas

On March 8, 2023 Estrella Biopharma, Inc. ("Estrella"), a biopharmaceutical company whose mission is to harness the evolutionary power of the human immune system to transform the lives of patients fighting cancer with safe, effective therapies, and TradeUP Acquisition Corp. ("TradeUP") (NASDAQ: UTPD), a special purpose acquisition company formed for the purpose of effecting a merger, acquisition or similar business combination, reported that the U.S. Food and Drug Administration ("FDA") has cleared Estrella’s Investigational New Drug ("IND") application for Estrella’s lead product candidate, EB103, a T-cell therapy targeting CD19, a protein expressed on the surface of almost all B-cell leukemias and lymphomas, paving the way for Estrella to initiate a Phase I/II clinical trial of EB103 to treat relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (NHL) patients, including clearance to treat patients with some of the highest unmet medical needs, including those with human immunodeficiency virus (HIV)-associated lymphoma, and primary and secondary central nervous system (CNS) lymphoma (Press release, Estrella Biopharma, MAR 8, 2023, View Source [SID1234628358]).

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"We are thrilled to have received FDA clearance for our IND application for EB103, which will allow us to evaluate its safety and efficacy in a broader range of patients, including those who are typically excluded from other clinical trials, often due to cytokine release syndrome (CRS) and neurotoxicity," said Dr. Cheng Liu, President and Chief Executive Officer of Estrella. "Our goal is to develop a safe and effective therapy that can help address the unmet medical needs of patients with R/R B-cell malignancies, including those who are currently underserved by existing therapies. We hope to enroll our first patient in the second half of 2023."

The Starlight-1 Phase I/II clinical trial is designed to assess the safety, tolerability, recommended Phase II dose (RP2D), and preliminary anti-cancer activity of EB103 for the treatment of R/R B-cell NHL patients. The study is expected to enroll patients initially at UC Davis Health.

About EB103

EB103, a T-cell therapy, also referred to as Estrella’s "CD19-Redirected ARTEMIS T-Cell Therapy," utilizes Eureka Therapeutics, Inc.’s ("Eureka’s") ARTEMIS technology pursuant to Estrella’s license agreement with Eureka to target CD19. Unlike a traditional CAR-T cell, the unique design of an ARTEMIS T-Cell, like EB103 T-cells, allows it to be activated and regulated upon engagement with cancer targets that use a cellular mechanism more closely resembling the one from an endogenous T-cell receptor. Once infused, EB103 T-cells seek out CD19-positive cancer cells, bind to these cells, and destroy them.

Medivir to present at the Stockholm Corporate Finance Life Science Day

On March 8, 2023 Medivir AB (Nasdaq Stockholm: MVIR), a pharmaceutical company focused on developing innovative treatments for cancer in areas of high unmet medical need, reported the company will participate at the Stockholm Corporate Finance Life Science Day on March 9, 2023 (Press release, Medivir, MAR 8, 2023, View Source [SID1234628357]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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CEO Jens Lindberg will present the company and its plan for the ongoing clinical study with fostroxacitabine bralpamide (fostrox) at 08.30 CET.

The presentation will be available after the meeting on Medivirs website; www.medivir.com.

For additional information, please contact

Magnus Christensen, CFO, Medivir AB
Telephone: +46 8 5468 3100
E-mail: [email protected]

Compugen to Participate in a Fireside Chat at the Oppenheimer 33rd Annual Healthcare Conference

On March 8, 2023 Compugen Ltd. (Nasdaq: CGEN) (TASE: CGEN), a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, reported that management will participate in a fireside chat at the Oppenheimer 33rd Annual Healthcare Conference (virtual), on Wednesday, March 15, 2023 at 10:00 AM ET (Press release, Compugen, MAR 8, 2023, View Source [SID1234628356]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live webcast of the fireside chat will be available on the Investor Relations section of Compugen’s website at www.cgen.com. A replay will be available following the live event for 90 days.

Accuray Incorporated to Speak at 33rd Annual Oppenheimer Healthcare Conference

On March 8, 2023 Accuray Incorporated (NASDAQ: ARAY) reported its participation in the 33rd Annual Oppenheimer Healthcare Conference taking place March 13-15, 2023 (Press release, Accuray, MAR 8, 2023, View Source [SID1234628355]). The management team is scheduled to participate in a fireside chat on Tuesday, March 14, 2023 at 1:00pm PST / 4:00pm EST.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live webcast of the fireside chat can be accessed on the Accuray website at investors.accuray.com. A replay will be available on the company’s website following the event. The webcast replay of the presentation will begin about one hour after the conclusion of the live presentation and will be available for approximately 90 days.

The Oppenheimer Conference will connect institutional investors to a wide variety of public and private healthcare companies spanning all major sectors of the healthcare industry.