Entry into a Material Definitive Agreement

On November 21, 2022, XOMA (US) LLC ("XOMA"), a wholly-owned subsidiary of XOMA Corporation (the "Company"), entered into an intellectual property acquisition agreement (the "Agreement") with ObsEva, SA, a Swiss biotech company ("ObsEva") (Press release, Xoma, NOV 21, 2022, View Source [SID1234624355]). Pursuant to the Agreement, XOMA has acquired all rights and title to ebopiprant, an investigational compound, previously licensed by ObsEva from Ares Trading SA ("Merck KGaA") pursuant to a certain license agreement dated June 10, 2015, held by ObsEva for $15 million, payable in cash at the closing, plus certain earn-out payments, based on some sales-based and non-sales milestones. XOMA has assumed the ebopiprant intellectual property estate and all license agreements, including a certain license agreement from ObsEva to Organon International GmbH dated July 26, 2021, related to the development and commercialization of ebopiprant (the "License Agreement"). XOMA is eligible to receive up to $475 million in development, regulatory, and sales-based milestone payments under the License Agreement. XOMA will pay to ObsEva a portion of the development and regulatory milestones, as well as certain sales milestones, up to $98 million. Upon commercialization, XOMA will receive royalties that range from low- to mid-teens from Organon and will make a mid-single-digit royalty payment to Merck KGaA.

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The Agreement contains certain covenants, representations and warranties regarding ObsEva’s rights and obligations with respect to the existing licenses, mutual indemnification provisions, and customary covenants and representations for a transaction of this nature.

The description of the Agreement contained herein does not purport to be complete and is qualified in its entirety by reference to such Agreement, a copy of which will be filed as an exhibit to the Company’s Annual Report on Form 10-K for the period ending December 31, 2022.

AnaptysBio to Participate at the Piper Sandler 34th Annual Healthcare Conference

On November 21, 2022 AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, reported that Dan Faga, interim chief executive officer of AnaptysBio, will represent the company in a fireside chat at the Piper Sandler 34th Annual Healthcare Conference on Tuesday November 29th, 2022, at 8:10 a.m. ET / 5:10 a.m. PT (Press release, AnaptysBio, NOV 21, 2022, View Source [SID1234624317]).

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A live audio webcast of the presentation will be available on the investor section of the AnaptysBio website at View Source A replay of the webcast will be available for 30 days following the event.

Nona Biosciences Enters into HCAb Based Drug Discovery Collaboration Agreement with Dragonfly Therapeutics

On November 21, 2022 Nona Biosciences, a wholly-owned subsidiary of HBM Holdings Limited committed to providing a total solution from "Idea to IND" ("I to ITM"), reported that it has entered into a collaboration agreement with Dragonfly Therapeutics based on Nona’s proprietary fully human heavy chain only antibody (HCAb) transgenic mice platform to discover and develop fully human heavy chain only antibodies for bispecific/multi-specific therapeutic antibody generation (Press release, Dragonfly Therapeutics, NOV 21, 2022, View Source [SID1234624315]).

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Through the collaboration, Nona Biosciences will provide Dragonfly Therapeutics with access to the HCAb technologies as well as antibody generation services for the targets designated by Dragonfly Therapeutics. Financial terms were not disclosed. The collaboration is Nona’s follows a recently announced license and collaboration agreement with Moderna for nucleic acid-based immunotherapies for select oncology targets.

Dr. Jingsong Wang, Founder, Chairman, and CEO of Harbour BioMed said: "The Dragonfly Therapeutics’ collaboration recognizes the potential of both our proprietary platform and antibody discovery capabilities. We believe that our HCAb technology together with our accumulated extensive experience in innovative biologics drug discovery will help our partners generate differentiated therapeutic molecules benefiting the patient worldwide."

About HCAb

HCAb’s patented technology generates novel "heavy chain only" antibodies, which are about half the size of a typical IgG. These antibodies carry IgG-like PK properties and Fc-domain functions without the need for additional engineering or humanization. Lack of light chain also minimizes the issue of light chain mispairing and heterodimerization. These characteristics enable the development of products with attributes not achievable by conventional antibody platforms. In addition, HCAb-derived multiple novel therapeutic antibody modalities, including single-domain antibodies, bi-, and multi-specifics, antibody-drug conjugates, CAR-Ts, or VH domain-derived diagnostic or therapeutic products, are also achievable using this platform.

Nordic Nanovector comment on Proposed Merger with APIM Therapeutics

On November 21, 2022 Nordic Nanovector ASA (OSE: NANOV) ("Nordic Nanovector" or the "Company") reported to share more information with the Company’s shareholders about the proposed merger between the Company and APIM Therapeutics ("APIM") (Press release, Nordic Nanovector, NOV 21, 2022, View Source [SID1234624314]). The Company has scheduled a webcast, including a question and answers session, on Thursday, November 24 at 4.30 CET. Practical details regarding the webcast will be issued in a separate notice. Any questions may be submitted to [email protected].

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The Board of Nordic Nanovector and its advisors reiterates its belief that the merger with APIM is in the best interests of all shareholders. The transaction creates a viable path to future value generation. The largest shareholders in Nordic Nanovector were made insiders and informed about the contemplated transaction ahead of the announcement in accordance with market practice.

The strategic review to explore the Company’s options has concluded that a stand-alone strategy is not a viable option. Through the review, Carnegie Investment Bank ("Carnegie") and the Company have held discussions with over 25 Nordic and international companies. Detailed discussions took place with several players in the health care sector, including companies with Phase 2 assets, with valuations representing higher dilution for Nordic Nanovector shareholders. These discussions were conducted with big pharma and other biotech companies, both listed and privately held. Opportunities for a transaction outside the health care sector, with companies particularly interested in listing on Oslo Børs main market and in the Company’s balance sheet assets, were also investigated.

However, these did not result in terms that were competitive or that recognised an appropriate valuation of the Company.

The proposed recommended merger with APIM brings access to a highly attractive Phase 2 oncology asset in ATX-101, a very experienced CEO and CMO, plus a strong investor base that understands the biotech industry and oncology drug development and will continue to support the new merged company through the next phase of its development. As part of the merger process, APIM and the R&D team at Nordic Nanovector, will evaluate the pipeline of both companies to determine the product development plan of the combined entity. This plan, including anticipated future milestones, will be presented to shareholders in the near future.

The Board urges the shareholders to make their own assessment for their investment decision and participation at the upcoming general meeting, either by proxy, advance voting or personal attendance. Despite the unfortunate circumstances of the Company following the closing of the PARADIGME trial, the Board of director’s opinion is that the proposed transaction is in the best interest of the Company and its shareholders.

Background to the Proposed Merger

The merger, which is backed by the Boards of both companies, is the result of an extensive review that explored a range of strategic options for the Company. The Company believes that this transaction, in this very difficult market environment where many biotech companies are running low on cash, represents an exciting opportunity for all shareholders given the significant and broad potential of ATX-101, a novel anti-cancer peptide currently in Phase 2 trials. In addition, the combined company will have the discovery and development expertise to potentially generate multiple future new drug candidates from its technology platforms.

Nordic Nanovector’s Board has carried out a robust review of its strategic options over the past months in conjunction with Carnegie. Following this review, the Board concluded that a stand-alone strategy was not a viable option given that Nordic Nanovector’s pipeline was centred on preclinical drug candidates that would require significant additional financial resources to advance and create shareholder value. Hence, the Company’s Board believes that the proposed merger with APIM Therapeutics is in the best interests of the Company and all its shareholders. This belief is based on the attractive prospects for the combined company, which is well placed to generate shareholder value.

In addition, the new combined company will also have the support of a group of knowledgeable life science investors including Sarsia Seed AS, Trond Mohn Stiftelsen, Norsk Innovasjonskapital III AS and Investinor Direkte AS.

Advisers

Carnegie Investment Bank is acting as financial advisor to Nordic Nanovector. Advokatfirmaet Selmer AS is acting as legal advisor to Nordic Nanovector and KPMG AS assisted Nordic Nanovector with financial due diligence and a fairness opinion of the exchange ratio.

Advokatfirmaet Schjødt AS is acting as legal advisor to APIM.

Treadwell Therapeutics Announces Presentations at the 2022 San Antonio Breast Cancer Symposium Featuring a Clinical Trial Update on the CFI-402257 and CFI-400945 programs

On November 21, 2022 Treadwell Therapeutics, a clinical-stage biotechnology company developing novel medicines for highly aggressive cancers, reported that four abstracts highlighting CFI-402257 and CFI-400945, the Company’s potent and selective inhibitors of TTK and PLK4, respectively, have been accepted for presentation at the 2022 San Antonio Breast Cancer Symposium (SABCS) being held from December 6-10, 2022 at the Henry B. Gonzalez Convention Center in San Antonio, Texas (Press release, Treadwell Therapeutics, NOV 21, 2022, View Source [SID1234624313]).

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"We are grateful that several abstracts highlighting our TTK and PLK4 inhibitor programs have been selected for presentation," said Dr. Michael Tusche, Treadwell co-CEO. "We look forward to additional data from these studies, as we further characterize the utility of our agents in various breast cancer settings."